The informed-consent process should be one of meaningful information exchange between researchers and study participants. One of the responsibilities of research ethics committees is to oversee appropriate inf...

The informed-consent process should be one of meaningful information exchange between researchers and study participants. One of the responsibilities of research ethics committees is to oversee appropriate informed consent. The committee must consider various matters before deciding whether the process is appropriate, including the adequacy and completeness of the written information provided to study participants, and the process of obtaining informed consent. This study aimed to identify, quantitatively and qualitatively, consent-related issues in different types of malaria proposals submitted to the (...) Faculty of Tropical Medicine, Ethics Committee. This study reviewed proposal documentation submitted to two panels of the Ethics Committee of the Faculty of Tropical Medicine, Mahidol University, from 2011 to 2015. The documentation included proposals, notifications to researchers of review outcomes and ethical issues of concern to committee members. Each element of the informed-consent process was identified and analyzed by study classification, design, and specimen use, including whether the study involved a vulnerable population. Summative content analysis was used to analyze patterns of common issues raised in reviews. Of the 112 proposals reviewed, 63 required an informed consent process. All researchers proposed communicating with their study participants; however, about two-thirds needed to improve their explanations of study procedures to participants. About 40% of the proposals attracted comments on informed-consent process elements--risk and discomfort, vulnerable status, and compensation. Studies that planned to collect or use new/linked specimens raised more issues around informed consent than studies using linked data/records. Studies that involved vulnerable populations raised more issues than those that did not. The committee usually asked researchers to clarify, elaborate, revise, or paraphrase the consent process elements that were considered to involve inadequate information exchange between researcher and study participant. This study aimed to describe lessons for malaria researchers about common informed-consent process issues in different types of malaria proposals. The information and analysis of informed-consent elements should assist the preparation of malaria-research proposals. (shrink)

Recruiting minorities into research studies requires special attention, particularly when studies involve “extra-vulnerable” participants with multiple vulnerabilities, e.g., pregnant women, the fetuses/neonates of ethnic minorities, children in refugee camps, or cross-border migrants. This study retrospectively analyzed submissions to the Ethics Committee of the Faculty of Tropical Medicine (FTM-EC) in Thailand. Issues related to the process and outcomes of proposal review, and the main issues for which clarification/revision were requested on studies, are discussed extensively.

Trika philosophy or Kashmir Śaivism is one of the major nondual philosophical systems of India where both esoteric and exoteric practices are included systematically and scientifically. The two aspects of manifestation viśvamaya, the immanent and viśvottīrṇa the transcendental covers this entire philosophical system as a unique all-inclusive and very practical. In this process of manifestation in Trika philosophy ‘māyā’ plays an important role both from an ontological and epistemological point of view. Furthermore ‘māyā’ clearly stands as a foremost part with (...) the point of view of a knower (pramātā). So, māyā is a quite notable concept, unlike other Indian philosophical traditions. Apart from this, it gives utmost support to artistic creations, i.e. both artist and aesthete, and because of that reason Pratyabhijñā darśan has a strong influence on Indian literary theory. This paper is an attempt to expound the major dimensions of ‘māyā’ in different levels. (shrink)

We present a framework for analyzing black hole backreaction from the point of view of quantum open systems using influence functional formalism. We focus on the model of a black hole described by a radially perturbed quasi-static metric and Hawking radiation by a conformally coupled massless quantum scalar field. It is shown that the closed-time-path (CTP) effective action yields a non-local dissipation term as well as a stochastic noise term in the equation of motion, the Einstein–Langevin equation. Once the thermal (...) Green's function in a Schwarzschild background becomes available to the required accuracy, the strategy described here can be applied to obtain concrete results on backreaction. We also present an alternative derivation of the CTP effective action in terms of the Bogolyubov coefficients, thus making a connection with the interpretation of the noise term as measuring the difference in particle production in alternative histories. (shrink)

Rifamycin is a clinically useful macrolide antibiotic produced by the gram positive bacterium. Amycolatopsis mediterranei. This antibiotic is primarily used against Mycobacterium tuberculosis and Mycobacterium leprae, causative agents of tuberculosis and leprosy, respectively. In these bacteria, rifamycin treatment specifically inhibits the initiation of RNA synthesis by binding to β‐subunit of RNA polymerase. Apart from its activity against the bacteria, rifamycin has also been reported to inhibit reverse transcriptase (RT) of certain RNA viruses. Recently, rifamycin derivatives have been dis‐covered that are (...) effective against Mycobacterium avium, which is associated with the AIDS complex. Consequently, the importance of and demand for rifamycin has increased tremendously, the world over. In this article, recent trends in rifamycin research and accessability of recombinant DNA techniques to increase rifamycin production are reviewed. (shrink)

This book examines the performance of Bauls 'folk' performers from Bengal, in the context of a rapidly globalizing Indian economy and against the backdrop of extreme nationalistic discourses. Recognizing their scope beyond the musical and cultural realm, Sukanya Chakrabarti engages in discussing the subversive and transformational potency of Bauls and their performances. In-Between Worlds argues that the Bauls through their musical, spiritual, and cultural performances offer 'joy' and 'spirituality', thus making space for what Dr. Ambedkar in his famous 1942 (...) speech had identified as 'reclamation of human personality'. Chakrabarti destabilizes the category of 'folk' as a fixed classification or an origin point, and fractures homogeneous historical representations of the Baul as a 'folk' performer and a wandering mendicant exposing the complex heterogeneity that characterizes this group. Establishing 'folk-ness' as a performance category, and 'folk festivals' as sites of performing 'folk-ness', contributing to a heritage industry that thrives on imagined and recreated nostalgia, Chakrabarti examines different sites that produce varied performative identities of Bauls, probing the limits of such categories while simultaneously advocating for polyvocality and multifocality. While this project has grounded itself firmly in performance studies, it has borrowed extensively from fields of postcolonial studies and subaltern histories, literature, ethnography and ethnomusicology, and cosmopolitan studies. (shrink)