Insulin‐dependent diabetes mellitus (IDDM) is an autoimmune disease whose etiology is complex. Both genetic susceptibility, which is polygenic, and environmental factors, including virus infections, appear to be involved in the development of IDDM. In this review, we have tried to balance the discussion of diabetes by examining both immunological and virological perspectives. Several mouse models, including viral and non‐viral models, have been used to study diabetes. For this review, we include lessons gleaned from the non‐obese diabetic (NOD) mouse and from (...) mouse models of coxsackievirus‐ and encephalomyocarditis‐virus‐induced diabetes. Finally, we present a multi‐stage model in which several viral infections, including the coxsackieviruses, are postulated to play a role in the autoimmune destruction of pancreatic beta cells. (shrink)

This paper publishes a gold ring until recently in private hands in the United States. The former owners, private persons with no scholarly background, brought the ring to the present writer's attention upon learning that he had some knowledge of Greek inscriptions. The one deplorable fact is that this ring was removed from its context, so that much of its scientific value is forever lost to us. Nonetheless, the damage was done by others years ago, and its owners deserve praise (...) for making the ring available for study. The dedicatory inscription on it is an invaluable example of early Argive script. The details of acquisition are unclear. I have been able to ascertain only that the ring was acquired in ancient Mycenae from some Greeks who claimed to have dug it up in the area. As will be seen, in all probability it comes from the Argive Heraion. (shrink)

The fire beacon in the opening scenes of the Agamemnon commands attention and creates the positive image of light from darkness. In the immediate context the light of the beacon relieves the watchman of his toil and brings joy to Argos. The image, however, is not totally positive. The fire signal announces both the fall of Troy and the return of Agamemnon to Clytemnestra. The negative aspect, furthermore, is emphasised at the opening — the watchman's joy at seeing the beacon (...) gives way at line 36 to foreboding . For the original audience of 458 b.c. I suggest that this fire beacon proclaiming victory must have conveyed other negative overtones. In brief, it will have recalled to them vividly the signals used by the Persian commanders during the great invasion of 480 to announce Athens' capture to an expectant Persian court. (shrink)