The current practice for UK Research Ethics Committees is to invite researchers to attend meetings at which their applications are to be considered and the National Research Ethics Service strongly recommends researchers to attend. There are no available data, however, to substantiate the value of researchers' attendance and particularly on the extent to which their attendance may influence the initial decision of the committee. This study attempts to address whether it is in the researchers' interest to commit substantial time and (...) resource to attend a REC meeting through using the REC decision on the research proposal as the main outcome measure. (shrink)

This book explores the impact of disintegrity on various aspects of governance, as the disregard of ecological conditions produce grave direct effects to human rights (to water or food) and, indirectly, also to human security in several ways. International legal regimes need to be reconsidered and perhaps re-interpreted, in order to correct these situations that affect the commons today. Some believe that our starting point should acknowledge the impact we already have on the natural world, and accept that we now (...) live in the "anthropocene". Others think that the present emphasis on sustainable development needs to be re-defined. Finally, many believe that reconnecting with moral principles both in professional life and in governance in general represents a necessary first step. (shrink)

...this work covers a great deal of philosophical ground, and it does so in a competent, workmanlike fashion which should be comprehensible even to a student in a lower level undergraduate introductory course.

The brain is an ever‐changing organ that encodes memories and directs behavior. Neuroanatomical studies have revealed structural plasticity of neural architecture, and advances in gene expression technology and epigenetics have demonstrated new mechanisms underlying the brain's dynamic nature. Stressful experiences challenge the plasticity of the brain, and prolonged exposure to environmental stress redefines the normative transcriptional profile of both neurons and glia, and can lead to the onset of mental illness. A more thorough understanding of normal and abnormal gene expression (...) is needed to define the diseased brain and improve current treatments for psychiatric disorders. The efforts to describe gene expression networks have been bolstered by microarray and RNA‐sequencing technologies. The heterogeneity of neural cell populations and their unique microenvironments, coupled with broad ranging interconnectivity, makes resolving this complexity exceedingly challenging and requires the combined efforts of single cell and systems level expression profiling to identify targets for therapeutic intervention. (shrink)

Samuel Scheffler postulates that we derive more value and meaning from our lives because we have confidence in the indefinite continuation of humanity than we do from our own or our loved ones’ continued existence. Scheffler believes that this shows humans to be less egocentric than some believe. He offers two thought experiments to motivate this intuition. The first thought experiment depends on the second to control for certain intuitions that run counter to the intuitions Scheffler wants to elicit. So, (...) Scheffler is committed to using both thought experiments. The second of the two, and the one on which the first depends, is a scenario in which people become infertile and humanity dies out over the course of a single generation. I argue that this scenario can be more reasonably taken to show that value and meaning in life does not depend on a collective afterlife. I argue that the particulars we value in such a scenario from both a normative and descriptive perspective may change, but that a robust notion of value, and consequently meaning, can exist despite the knowledge that humanity will not continue indefinitely into the future. I also address the reason we might find the slow extinction of humanity unsettling for reasons unrelated to the loss of a collective afterlife. I conclude by presenting a thought experiment challenging the idea that the afterlife conjecture deals any substantial blow to the supposed extent of human egocentrism. (shrink)

In Alan Bennett’s play The History Boys, Irwin, a sixth-form history tutor destined for a media career (based, it is rumored, on that specialist in historical controversy Niall Ferguson) sets out his views on how a difficult change in the law that will affect individual rights should be dealt with. The tactic Irwin advocates is for the Government to insist that the Bill, rather than reducing the liberty of the subject “amplifies it.” The use of paradox, notes Irwin, “works well (...) . . . the loss of liberty is the price we pay for freedom type thing” (Bennett 2004, 3). Thus, in a few sentences, Bennett encapsulates one of the greatest, or, at least, what we in the West have come to think of as one of the greatest, of .. (shrink)

The current practice for UK research ethics committees is to invite researchers to attend meetings at which their applications are to be considered and for student-based research the National Research Ethics Service recommends supervisors to attend. This study aims to identify the extent to which students and their supervisors attend NHS REC meetings and whether attendance is associated with the initial outcomes of RECs.

In this paper, I will give a new characterisation of the spaces of complete theories of pseudofinite fields and of algebraically closed fields with a generic automorphism (ACFA) in terms of the Vietoris topology on absolute Galois groups of prime fields.