The brain is an ever‐changing organ that encodes memories and directs behavior. Neuroanatomical studies have revealed structural plasticity of neural architecture, and advances in gene expression technology and epigenetics have demonstrated new mechanisms underlying the brain's dynamic nature. Stressful experiences challenge the plasticity of the brain, and prolonged exposure to environmental stress redefines the normative transcriptional profile of both neurons and glia, and can lead to the onset of mental illness. A more thorough understanding of normal and abnormal gene expression (...) is needed to define the diseased brain and improve current treatments for psychiatric disorders. The efforts to describe gene expression networks have been bolstered by microarray and RNA‐sequencing technologies. The heterogeneity of neural cell populations and their unique microenvironments, coupled with broad ranging interconnectivity, makes resolving this complexity exceedingly challenging and requires the combined efforts of single cell and systems level expression profiling to identify targets for therapeutic intervention. (shrink)

Samuel Scheffler postulates that we derive more value and meaning from our lives because we have confidence in the indefinite continuation of humanity than we do from our own or our loved ones’ continued existence. Scheffler believes that this shows humans to be less egocentric than some believe. He offers two thought experiments to motivate this intuition. The first thought experiment depends on the second to control for certain intuitions that run counter to the intuitions Scheffler wants to elicit. So, (...) Scheffler is committed to using both thought experiments. The second of the two, and the one on which the first depends, is a scenario in which people become infertile and humanity dies out over the course of a single generation. I argue that this scenario can be more reasonably taken to show that value and meaning in life does not depend on a collective afterlife. I argue that the particulars we value in such a scenario from both a normative and descriptive perspective may change, but that a robust notion of value, and consequently meaning, can exist despite the knowledge that humanity will not continue indefinitely into the future. I also address the reason we might find the slow extinction of humanity unsettling for reasons unrelated to the loss of a collective afterlife. I conclude by presenting a thought experiment challenging the idea that the afterlife conjecture deals any substantial blow to the supposed extent of human egocentrism. (shrink)