The European Clinical Trials Directive (EU 2001; 2001/20/EC) was introduced to improve the efficiency of commercial and academic clinical trials. Concerns have been raised by interested organizations and institutions regarding the potential for negative impact of the Directive on non-commercial European clinical research. Interested researchers within the European Group for Blood and Marrow Transplantation (EBMT) were surveyed to determine whether researcher experiences confirmed this view. Following a pilot study, an internet-based questionnaire was distributed to individuals in key research positions in (...) the European haemopoietic SCT community. Seventy-one usable questionnaires were returned from participants in different EU member states. The results indicate that the perceived impact of the European Clinical Trials Directive has been negative, at least in the research areas of interest to the EBMT. (shrink)

A direct method showing the Thomas precession for an evolution of any vector quantity (a spatial part of a four-vector) is proposed. A useful application of this method is a possibility to trace correctly the presence of the Thomas precession in the Bargmann-Michel-Telegdi equation. It is pointed out that the Thomas precession is not incorporated in the kinematical term of the Bargmann-Michel-Telegdi equation, as it is commonly believed. When the Bargmann-Michel-Telegdi equation is interpreted in curved spacetimes, this term is shown (...) to be equivalent to the affine connection term in the covariant derivative of the spin four-vector evolving in a gravitational field. It then contributes to the geodetic precession. The described problem is an interesting and unexpected example showing that approximate methods used in special relativity, in this case to identify the Thomas precession, can distort the true meaning of physical laws. (shrink)

Imagine that you are a teenager and have cancer. You undergo a year of chemotherapy and after a brief return to normal life, you have a relapse. Your physician says that chemotherapy and radiation therapy could be tried, but a bone marrow transplant is your only chance of a real cure. He tells you and your parents that you could die as a result of complications from the transplant, but without it you would only be expected to live one year. (...) You and your family discuss the alternatives and decide to have the transplant. You ask what will happen if the BMT fails, but both your physician and your family tell you that right now you must fight to get better and not think negative thoughts. You do not ask any more questions. (shrink)

A great effort has been devoted to formulating a classical relativistic theory of spin compatible with quantum relativistic wave equations. The main difficulty in connecting classical and quantum theories rests in finding a parameter that plays the role of proper time at a purely quantum level. We present a partial review of several proposals of classical and quantum spin theories from the pioneering works of Thomas and Frenkel, revisited in the classical BMT work, to the semiclassical model of Barut and (...) Zanghi. We show that the last model can be obtained from a semiclassical limit of the Feynman proper time parametrization of the Dirac equation. At the quantum level, we derive spin precession equations in the Heisenberg picture. Analogies and differences with respect to classical theories are discussed in detail. (shrink)

When space-reflection and time-reversal symmetries are broken, the Thomas precession formulas derived by Thomas' method and from the BMT equation differ from each other. This apparent contradiction is resolved by pointing out that the breakdown of discrete symmetries may lead to a change in the operational meaning of the Lorentz-group elements.

Many inherited metabolic diseases may lead to varying degrees of brain damage and thus also to intellectual disability. Bone marrow transplantation (BMT) has been used for over two decades as a form of secondary prevention to stop or reverse the progress of the disease process in some of these conditions. At the population level the impact of BMT on the prevalence of intellectual disability is minute, but at the individual level its impact on the prognosis of the disease and the (...) well-being of the patient can be substantial. The dark side of BMT use is the burden of side effects, complications and transplantation-related mortality in less successful cases. The ethical issues involved in this therapy are discussed in this review. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:How I Lost My HearingJanessa SalesI was born as a healthy and strong hearing person, but I became deaf through a result of painful and traumatic cancer treatments. I was diagnosed with a malignant brain tumor called Germinoma in 2003. I went through surgery, chemotherapy, and radiation. I was good for one and a half years. However, in 2005 when I turned 12 my cancer relapsed. My doctors told (...) me and my family that I had to undergo a much stronger treatment plan called a Bone Marrow Transplant (BMT). One of the possible side effects to this treatment was hearing loss. I unfortunately received this devastating side effect.I still remember the day that I lost my hearing. Before going to sleep that night, I received a dose of chemo. Waking up the next morning, something was terribly wrong. I couldn’t hear anything! I felt as if I were wearing earplugs. I called for my mother and I told her the alarming news, but as she was speaking back to me, I strained to hear her voice. All I saw were her lips moving. My doctors made arrangements for me to get my hearing tested with an audiologist.As the days that passed, I went through a deep depression. My doctors and my family tried different ways to communicate with me. They used note pads or white boards and wrote down what they wanted to say to me. As my hearing lessened, my other senses kicked in. I read body language and expressions. I learned to read lips. It was a little over a month before I got my hearing aids.Going back to school was very difficult, but my hearing loss, in itself, wasn’t as traumatic as the refusal to accept my new life. I spent the next four years trying to be hearing—trying to fix myself— trying to be what I once was. I always strained my ears trying to listen to my teachers. I tried fitting in with my friends, trying to keep up with their conversations, but it was no use. I couldn’t hear a thing; I was lost and confused.However, during my eighth grade year, I was given the choice to transfer to a different school. It was a mainstream school that had a DHH (Deaf and Hard of Hearing) program. It was a scary transition going to a new school, not knowing anybody. I hesitated and did not want to go at first, but eventually I got over my fears.When I transferred over to the other middle school, I still felt lost. I was still trying to be a hearing student. I only knew how to be auditory learner. I couldn’t focus because I wasn’t able to hear my teachers. I was new at sign language, so I couldn’t understand any of my interpreters. I had frequent meltdowns every week.I felt like I didn’t fit into the deaf world or the hearing world. I couldn’t understand either one. I was always misunderstanding my hearing friends, and I wasn’t able to understand my deaf peers because I didn’t fully know their language. I had low self–esteem and I felt like I didn’t belong anywhere.I had to learn to become a visual learner. I was given the use of a Frequency Modulated (FM) system. The FM system is an assistive listening device worn by the speaker to amplify his/her voice and transmit it directly to the listener’s ears via an electronic receiver and special earphones or the listener’s own hearing aids. I also had an interpreter and closed captions when needed.My DHH teacher Mr. H, who was my greatest mentor and role model, set me up with an Individualized Educational Program (IEP) that required that I had to have my homework written down instead being verbally told. I was allowed to have more time on tests when needed, and a note taker for lectures. All of these arrangements really helped me through my new “deaf world.”My mother and I took Sign Language classes at Sacramento State University where Mr. H also taught... (shrink)

본 연구의 목적은 최근 20여 년 동안 진행되어 온 학습이론에 대한 피아제의 명제논리학적 학습이론과 베이즈주의의 확률론적 학습이론의 융합에 근거하는 새로운 융합교수학습모형을 개발하는 것이다. 연구자는 이 새로운 교수학습모델을 “베이지안 구조구성주의 교수학습모형”(Bayesian structure-constructivist Model of Teaching-learning: 이하 약칭 BMT)이라 명명한다. 본고는 역사-비판적 관점 및 형식화적 관점에서 피아제의 명제논리학적 학습모형에서 해석된 학습이론과 베이즈주의의 확률론적 추론모형에서 해석된 학습이론을 일차적으로 분석하고, 논문의 후반부에서는 이를 근거로 교수법의 관점에서 양자의 학습이론을 통합하는 새로운 교수학습모델, 즉 BMT의 중요한 특성들을 세부적으로 제시한다. 몇 가지 핵심만 언급하면, 첫째로, BMT는 개념 학습이든 (...) 이론 학습이든 모든 학습은 표상과 샘플링의 상호작용임을 강조한다. 매우 이른 나이에서부터 아동은 학습하기 이전에 자기에게 주어진 예시들이 약한 샘플링인지 강한 샘플링인지, 특히 교육학적 샘플링인지 비교육학적 샘플링인지를 구분한다. 둘째로, 따라서 학습을 촉진시킬 수 있는 샘플을 선택하기 위해서 교사는 교육학적 추론을 위한 베이지안 모델을 활용하면서 직접적인 강의식 수업과 발견학습 수업을 병행해야 한다. 셋째로, 아동은 때때로 구체적인 규칙들보다는 추상적인 규칙들을 먼저 학습하기도 하지만, 대부분의 영역에서 추상적인 지식의 학습은 구체적인 지식의 학습에 의존한다. 따라서 성공적인 학습을 위해서는 피아제가 강조한 보편적 언어로서 논리적 문법과 그들 사이의 위계성을 고려하는 샘플을 개발하고 제시해야 한다. (shrink)

Imagine that you are a teenager and have cancer. You undergo a year of chemotherapy and after a brief return to normal life, you have a relapse. Your physician says that chemotherapy and radiation therapy could be tried, but a bone marrow transplant is your only chance of a real cure. He tells you and your parents that you could die as a result of complications from the transplant, but without it you would only be expected to live one year. (...) You and your family discuss the alternatives and decide to have the transplant. You ask what will happen if the BMT fails, but both your physician and your family tell you that right now you must fight to get better and not think negative thoughts. You do not ask any more questions. (shrink)

The only hope of survival for children with a number of life-threatening illnesses is a successful bone marrow transplant (BMT). Unlike the treatment source for most therapies, the raw material for transplant therapy comes from a human being. Although, many BMTs are autologous, utilizing the patient's own bone marrow, a large percentage of childhood BMTs rely on bone marrow from children or adolescents who are biological siblings to the sick child. Medical and legal systems are confronted with a dilemma when (...) healthy children are needed to undergo minimally risky, yet somewhat painful, procedures for the benefit of their critically ill siblings. This article reviews legal issues involved in sibling bone marrow donation and psychological research that is relevant to those issues. The article concludes with proposed directions for future psycholegal research and a discussion of ethical issues that are not amenable to empirical investigation. (shrink)

Under the assumption that business ethics can be enhanced by evaluating the affects of decisions on others, this essay demonstrates a case study in stakeholder analysis. While much normative literature has been compiled on the subject of stakeholder management, even more can be learned from the first-hand observation of stakeholder interactions. The purpose of this essay is to present a model of Basic Manufacturing Technologies' stakeholder universe, and illustrate how this manufacturer of steel interacts with its stakeholders. The conclusion which (...) is drawn suggests that these relationships are more complex than BMT's stakeholder philosophy portrays. (shrink)