Abstract
The issue of phenomenological reduction proceeds from the methodological requirement of the absence of presupposition : however, transcendental subjectivity as an actor of the reduction constitutes a presupposition that is inherent to Husserl’s approach. Radicality would then impose a reduction the subject submits to, not a reduction the subject chooses. That is how disease was considered by Nietzsche. Indeed, disease is the event through which subjective flesh shows itself from itself, in pathological phenomena, and shows itself as the ground and origin of any sense and value. Disease encloses the subject in the sphere of his immanent lived-experiences, where the essence of being reveals itself as pathos : it operates what is to be called a pathological reduction. From this ordeal Nietzsche shows then that metaphysics is “pathologically determined”, and he discloses its pathogenic, i.e. nihilist, character.