On the application of formal principles to life science data: A case study in the Gene Ontology

In Köhler Jacob, Kumar Anand & Smith Barry (eds.), Proceedings of DILS 2004 (Data Integration in the Life Sciences), (Lecture Notes in Bioinformatics 2994). Springer. pp. 79-94 (2004)
  Copy   BIBTEX

Abstract

Formal principles governing best practices in classification and definition have for too long been neglected in the construction of biomedical ontologies, in ways which have important negative consequences for data integration and ontology alignment. We argue that the use of such principles in ontology construction can serve as a valuable tool in error-detection and also in supporting reliable manual curation. We argue also that such principles are a prerequisite for the successful application of advanced data integration techniques such as ontology-based multi-database querying, automated ontology alignment and ontology-based text-mining. These theses are illustrated by means of a case study of the Gene Ontology, a project of increasing importance within the field of biomedical data integration.

Other Versions

No versions found

Links

PhilArchive

External links

  • This entry has no external links. Add one.
Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Enhancing GO for the sake of clinical bioinformatics.Anand Kumar & Barry Smith - 2004 - Proceedings of the Bio-Ontologies Workshop , Glasgow 133.
Ontology for the Intelligence Analyst.Barry Smith - 2012 - CrossTalk 14 (Nov/Dec):18-25.
Ontology (science).Barry Smith - 2001 - In Barry Smith & Christopher Welty (eds.), Formal Ontology in Information Systems (FOIS). ACM Press. pp. 21-35.
The ontology of the Gene Ontology.Barry Smith, Jennifer Williams & Steffen Schulze-Kremer - 2003 - In Smith Barry, Williams Jennifer & Schulze-Kremer Steffen (eds.), AMIA 2003 Symposium Proceedings. AMIA. pp. 609-613.

Analytics

Added to PP
2017-11-09

Downloads
752 (#29,496)

6 months
145 (#29,025)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Barry Smith
University at Buffalo

References found in this work

The ontology of the Gene Ontology.Barry Smith, Jennifer Williams & Steffen Schulze-Kremer - 2003 - In Smith Barry, Williams Jennifer & Schulze-Kremer Steffen (eds.), AMIA 2003 Symposium Proceedings. AMIA. pp. 609-613.

Add more references