Three leading scholars examine one of the oldest professorships, the Lady Margaret's Chair of Divinity at Cambridge, plotting its development in the context of sixteenth- and seventeenth-century history. The current Lady Margaret's Professor Graham Stanton sets the scene with an introduction briefly considering theology at Cambridge before 1502 and after 1649. In the two main chapters Richard Rex - an authority on John Fisher, first holder of the Chair - deploys new evidence to propose changes in the list of early (...) professors and shows how their appointment and dismissal reflected the vagaries of the Reformation; and Patrick Collinson investigates how the Elizabethan and early Stuart professors continued to be caught up in the religious and political turmoil of the times. There is a complete list of holders from 1502 to the present. (shrink)

Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes and (...) autophagosomes early in photoreceptor development. An analysis of autophagic flux revealed that autophagosomes accumulate because of a defect in maturation. In addition we found an increase in vesicles that are highly enriched for PI(3)P, but negative for an early endosome marker in nrca14 cones. A mutational analysis of SynJ1 enzymatic domains found that activity of the 5'phosphatase, but not the Sac1 domain, is required to rescue both aberrant late endosomes and autophagosomes. Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrca14 cones. Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. -/- . (shrink)

This paper focuses on two problems connected with our sources for Athenian politics between 510/09 and 488/7 B.C.: In the Athenaion Politeia attributed to Aristotle, ostracism is included in the laws of Cleisthenes. But later the author of the Ath. dates the first ostracism to the year 488/7. Depending on the date of Cleisthenes' laws, this leaves a gap of thirteen to twenty years between the institution of ostracism and its first use. Yet the very nature of the law suggests (...) that it was passed for immediate use. Cleisthenes' rival, Isagoras, is described in Ath. 20.1 as φίλος τῶν τυράννων. This label conflicts with two details in the political struggle. It involves Cleomenes, who had recently expelled the tyrants from Athens, in an astounding volte-face in supporting one who is known as φίλος τῶν τνράννων. Secondly, Isagoras had had the opportunity of imposing by force the kind of government he wanted—but it was an oligarchy, not a tyranny. How did the inappropriate label originate?The reaction of most scholars to the first problem has been to reject the ascription of ostracism to Cleisthenes in Ath. 22.1 and 22.4 and date the institution of ostracism to shortly before the first recorded ostracism. (shrink)