Several target articles in this BBS special issue address the topic of cerebellar and olivary functions, especially as they pertain to motor earning. Another important topic is the neural interaction between the limbic system and the cerebellum during associative learning. In this commentary we present some of our data on olivo-cerebellar and limbic-cerebellar interactions during eyeblink conditioning. [HOUK et al.; SIMPSON et al.; THACH].

Shors & Matzel somewhat lightly dismiss the evidence that a process like LTP may underlie the learning-induced increase in neuronal activity in the hippocampus in eyeblink conditioning. I provide some 12 lines of evidence supporting this hypothesis and the further hypothesis that this learning-induced LTP-like hippocampal plasticity can play a critical role in certain aspects of learned behavior.

The propositional nature of human associative learning is strongly supported by studies of trace eyeblink and fear conditioning, in which awareness of the contingency of a conditioned stimulus upon an unconditioned stimulus is a prerequisite for successful learning. Studies of animal lesion and human imaging suggest that the hippocampus is critical for establishing functional connections between awareness and trace conditioning.

We present techniques for integrating low‐level neurobiological constraints into high‐level, functional cognitive models. In particular, we use these techniques to construct a model of eyeblink conditioning in the cerebellum based on temporal representations in the recurrent Granule‐Golgi microcircuit.

Human errors are widely considered among the major causes of road accidents. Furthermore, it is estimated that more than 90% of vehicle crashes causing fatal and permanent injuries are directly related to mental tiredness, fatigue, and drowsiness of the drivers. In particular, driving drowsiness is recognized as a crucial aspect in the context of road safety, since drowsy drivers can suddenly lose control of the car. Moreover, the driving drowsiness episodes mostly appear suddenly without any prior behavioral evidence. The present (...) study aimed at characterizing the onset of drowsiness in car drivers by means of a multimodal neurophysiological approach to develop a synthetic electroencephalographic -based index, able to detect drowsy events. The study involved 19 participants in a simulated scenario structured in a sequence of driving tasks under different situations and traffic conditions. The experimental conditions were designed to induce prominent mental drowsiness in the final part. The EEG-based index, so-called “MDrow index”, was developed and validated to detect the driving drowsiness of the participants. The MDrow index was derived from the Global Field Power calculated in the Alpha EEG frequency band over the parietal brain sites. The results demonstrated the reliability of the proposed MDrow index in detecting the driving drowsiness experienced by the participants, resulting also more sensitive and timely sensible with respect to more conventional autonomic parameters, such as the EyeBlinks Rate and the Heart Rate Variability, and to subjective measurements. (shrink)

The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such ...

In the last third of the twentieth century, humanists and social scientists argued that attention to genetics would heighten already‐existing genetic determinism, which in turn would intensify negative social outcomes, especially sexism, racism, ableism, and harshness to criminals. They assumed that laypeople are at risk of becoming genetic essentialists. I will call this the “laypeople are genetic essentialists model.” This model has not accurately predicted psychosocial impacts of findings from genetics research. I will be arguing that the failure of the (...) model can be traced to its inability to recognize the complexity of laypeople’s attitudes; its incorrect theory of how beliefs, attitudes, and discourse function; and its blindness to how academics’ own interests can override the available evidence. More specifically, I suggest that the substantial data about laypeople’s deployment of genetics supports what I will call the “laypeople are strategic essentialists model” better than the “laypeople are genetic essentialists model.” The strategic essentialists model holds that people tend to store multiple categories, including multiple causal forces, that they deploy “strategically” to serve context‐dependent goals. It will be difficult for academics to reorient ourselves to model laypeople as sophisticated strategic essentialists rather than as naïve genetic essentialists. Perhaps a little shift, however, will be of value. (shrink)

Clark Glymour, together with his students Peter Spirtes and Richard Scheines, did pioneering work on graphical causal models . One of the central advances provided by these models is the ability to simply represent the effects of interventions. In an elegant paper , Glymour and his student Christopher Meek applied these methods to problems in decision theory. One of the morals they drew was that causal decision theory should be understood in terms of interventions. I revisit their proposal, and extend (...) the analysis by showing how graphical causal models might be used to address decision problems that arise in “exotic” situations, such as those involving crystal balls or time travelers. (shrink)

In his recent book, Time and Chance, David Albert claims that by positing that there is a uniform probability distribution defined, on the standard measure, over the space of microscopic states that are compatible with both the current macrocondition of the world, and with what he calls the “past hypothesis”, we can explain the time asymmetry of all of the thermodynamic behavior in the world. The principal purpose of this paper is to dispute this claim. I argue that Albert's proposal (...) fails in his stated goal—to show how to use the time‐reversible dynamics of Newtonian physics to “underwrite the actual content of our thermodynamic experience” (Albert 2000, 159). Albert's proposal can satisfactorily explain why the overall entropy of the universe as a whole is increasing, but it does not and cannot explain the increasing entropy of relatively small, relatively short‐lived systems in energetic isolation without making use of a principle that leads to reversibility objections. (shrink)

Jeffrey conditioning tells an agent how to update her priors so as to grant a given probability to a particular event. Weighted averaging tells an agent how to update her priors on the basis of testimonial evidence, by changing to a weighted arithmetic mean of her priors and another agent’s priors. We show that, in their respective settings, these two seemingly so different updating rules are axiomatized by essentially the same invariance condition. As a by-product, this sheds new light (...) on the question how weighted averaging should be extended to deal with cases when the other agent reveals only parts of her probability distribution. The combination of weighted averaging and Jeffrey conditioning is a comprehensive updating rule to deal with such cases, which is again axiomatized by invariance under embedding. We conclude that, even though one may dislike Jeffrey conditioning or weighted averaging, the two make a natural pair when a policy for partial testimonial evidence is needed. (shrink)

Richard Jeffrey espoused an antifoundationalist variant of Bayesian thinking that he termed ‘Radical Probabilism’. Radical Probabilism denies both the existence of an ideal, unbiased starting point for our attempts to learn about the world and the dogma of classical Bayesianism that the only justified change of belief is one based on the learning of certainties. Probabilistic judgment is basic and irreducible. Bayesian conditioning is appropriate when interaction with the environment yields new certainty of belief in some proposition but leaves (...) one’s conditional beliefs untouched (the ‘Rigidity’ condition). Although Richard Jeffrey denied the general applicability of this condition, one of his main contributions to probabilistic thinking is a form of belief updating—now typically called ‘Jeffrey conditioning’ or ‘probability kinematics’—that is appropriate in circumstances in which Rigidity is satisfied, but where the interaction causes one to reevaluate one’s probability judgments over some partition of the possibility space without conferring certainty on any particular element. The most familiar occasion for Jeffrey conditioning is receipt of uncertain evidence: things partially perceived or remembered. But it also serves to illuminate belief updating occasioned by a change in one’s degrees of conditional belief, a kind of belief change largely ignored by classical Bayesianism. I argue that such changes in conditional belief can also be basic (in the sense of not being analyzable as a consequence of conditioning on factual information) and offer a kinematical model for a particular kind change in conditional belief. Both are applied to changes in preference. Finally, I argue that Rigidity can fail when changes of belief give inferential grounds for changes in conditional belief (and vice versa). These failures show that conditioning methods are properly regarded, not as valid rules of inference, but as tools in the ‘art of judgment’. (shrink)

Anders, Rudi Mental conditioning is like gravity; it feels so normal and ever-present that it often goes unnoticed, but it influences much human behaviour. I am not free when I am not aware how my ideas and attitudes are absorbed from my culture, family, the media and peers. It takes courage to stand alone.

Richard Jeffrey's generalization of Bayes' rule of conditioning follows, within the theory of belief functions, from Dempster's rule of combination and the rule of minimal extension. Both Jeffrey's rule and the theory of belief functions can and should be construed constructively, rather than normatively or descriptively. The theory of belief functions gives a more thorough analysis of how beliefs might be constructed than Jeffrey's rule does. The inadequacy of Bayesian conditioning is much more general than Jeffrey's examples of (...) uncertain perception might suggest. The ``parameter α '' that Hartry Field has introduced into Jeffrey's rule corresponds to the "weight of evidence" of the theory of belief functions. (shrink)

Randomized Controlled Trials are currently the gold standard within evidence-based medicine. Usually, they are conducted as sequential trials allowing for monitoring for early signs of effectiveness or harm. However, evidence from early stopped trials is often charged with being biased towards implausibly large effects. To our mind, this skeptical attitude is unfounded and caused by the failure to perform appropriate conditioning in the statistical analysis of the evidence. We contend that a shift from unconditional hypothesis tests in the style (...) of Neyman and Pearson to conditional hypothesis tests gives a superior appreciation of the obtained evidence and significantly improves the practice of sequential medical trials, while staying firmly rooted in frequentist methodology. (shrink)

The ambiguity to which Porpora (1980) objects in Wright's (1972, 1976) analysis of goal-directedness permits certain counterexamples to Porpora's analysis to be easily accommodated by Wright's. As a consequence, Ringen's (1976) claim that some operant behavior is goal-directed is in accord with Wright's analysis and with certain features of common sense that Wright's analysis captures. However, the way our commonsense conception of goal-directedness accommodates some of the counterexamples to Porpora's analysis suggests an intimate connection between goal-directedness and intentional notions like (...) belief and desire. This suggests a possible criticism of Ringen and highlights problematic aspects of contemporary folk psychology. (shrink)

The human propensity for casting our social worlds as "us against them" is perhaps the primary impediment to deep and broadly inclusive understandings of the workings of rhetoric. Many decades ago, Kenneth Burke assailed that barrier with regard to Adolf Hitler. Surrounded by the satisfactions of vituperation against the leader of one of the world's most heinous social movements, Burke begged his readers to make space for understanding how Hitler's rhetoric brought about what it did. Philippe-Joseph Salazar's Words Are Weapons (...) makes a similar contribution for our era. He asks us to resist the gratifications generated by dismissing as "Islamaphobic" any critical analysis of what he calls "caliphal"... (shrink)