One way to make philosophy of science more socially relevant is to attend to specific scientific practises that affect society to a great extent. One such practise is biomedical research. This paper looks at contemporary U.S. biomedical research in particular and argues that it suffers from important epistemic, moral and socioeconomic failings. It then discusses and criticises existing approaches to improve on the status quo, most prominently by Thomas Pogge (a political philosopher), Joseph Stiglitz (a Nobel-prize winning economist) and James (...) Robert Brown (a philosopher of science). Finally, it sketches an alternative proposal and argues for its superiority. The proposal has four components: changing the intellectual property regime; instituting independent clinical research; aligning innovators' and patients' interests; and enacting additional regulation. (shrink)

In this paper we make a proposal for reforming biomedical research that is aimed to align re-search more closely with the so-called fair-share principle according to which the proportions of global resources as-signed to different diseases should agree with the ratios of human suffering associated with those diseases.

In this paper we make a proposal for reforming biomedical research that is aimed to align re-search more closely with the so-called fair-share principle according to which the proportions of global resources as-signed to different diseases should agree with the ratios of human suffering associated with those diseases.

This is an important book precisely because there is none other quite like it.

In this paper we make a proposal for reforming biomedical research that is aimed to align research more closely with the so-called fair-share principle according to which the proportions of global resources assigned to different diseases should agree with the ratios of human suffering associated with those diseases.

In pure science, the standard approach to non-epistemic values is to exclude them as far as possible from scientific deliberations. When science is applied to practical decisions, non-epistemic values cannot be excluded. Instead, they have to be combined with scientific information in a way that leads to practically optimal decisions. A normative model is proposed for the processing of information in both pure and applied science. A general-purpose corpus of scientific knowledge, with high entry requirements, has a central role in (...) this model. Due to its high entry requirements, the information that it contains is sufficiently reliable for the vast majority of practical purposes. However, for some purposes, the corpus needs to be supplemented with additional information, such as scientific indications of danger that do not satisfy the entry requirements for the corpus. The role of non-epistemic values in the evaluation of scientific information should, as far as possible, be limited to determining the level of evidence required for various types of practical decisions. (shrink)

The moral terrain of science, the full range of ethical considerations that are part of the scientific endeavor, has not been mapped. Without such a map, we cannot examine the responsibilities of scientists to see if the institutions of science are adequately constructed. This paper attempts such a map by describing four dimensions of the terrain: (1) the bases to which scientists are responsible (scientific reasoning, the scientific community, and the broader society); (2) the nature of the responsibility (general or (...) role); (3) the level of responsibility (minimum demand or ideal); and (4) who bears the responsibility (the individual or the community). Such a map will be used to elucidate the recent debate over the publication of studies concerning H5N1 flu virus. (shrink)

Science studies scholars of the twenty-first century have been arguing for a reconceptualization of science based on the emergence of new values and practices. Allegedly, these new norms have come from science in the context of application. However, the argument here is that science in the context of application is a phenomenon with as long and rich a history as so-called pure or basic science. Science in the context of application only appears to be new since so little light has (...) been shined on applied science by historians and philosophers of science. This article explores the consequences of reaching back into remote history seeking science in the context of application and finds that doing so helps scholars understand present day developments, as well. Three examples of historical applied science are explored: ancient Roman engineering, Enlightenment-era navigation and surveying, and American early Republic engineering. In addition, the work of I. Bernard Cohen is examined for historiographical evidence of a narrowing account of what counts as science in the post-WWII period. (shrink)

Anecdotes have shown that some articles on profitable drugs are constructed by and shepherded through publication by pharmaceutical companies and their agents, whose influence is largely invisible to readers. This is ghost-management, the substantial but unrecognized research, analysis, writing, editing and/or facilitation behind publication. Publicly available documents suggest that these practices extremely widespread affecting up to 40% of clinical trial reports in key periods but it has been unclear how representative these documents are. This article presents the results of an (...) investigative sampling of the self-presentation of publication planning services, and presents this and other evidence of a sizable publication planning industry. Thus different lines of evidence indicate that ghost-management is a common and important phenomenon, strongly affecting the published medical literature in the service of marketing. (shrink)