A Critique of Clinical Equipoise: Therapeutic Misconception in the Ethics of Clinical Trials

Hastings Center Report 33 (3):19-28 (2003)
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Abstract

A predominant ethical view holds that physician‐investigators should conduct their research with therapeutic intent. And since a physician offering a therapy wouldn't prescribe second‐rate treatments, the experimental intervention and the best proven therapy should appear equally effective. "Clinical equipoise" is necessary. But this perspective is flawed. The ethics of research and of therapy are fundamentally different, and clinical equipoise should be abandoned.

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Franklin Miller
Columbia University

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