YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations

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Abstract

Uveal melanoma is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein, q polypeptide, or G Protein, α 11. We show that the Yes-associated protein inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.

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Kang Zhang
Renmin University of China

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