Friends, colleagues, and students honor Hansjorg Otto, scholar and teacher, on his 70th birthday with this commemorative publication. ".

Protein complexes perform many important functions in the cell. Large‐scale studies of protein–protein interactions have not only revealed new complexes but have also placed many proteins into multiple complexes. Whilst the advocates of hypothesis‐free research touted the discovery of these shared components as new links between diverse cellular processes, critical commentators denounced many of the findings as artefacts, thus questioning the usefulness of large‐scale approaches. Here, we survey proteins known to be shared between complexes, as established in the literature, and (...) compare them to shared components found in high‐throughput screens. We discuss the various challenges to the identification and functional interpretation of bona fide shared components, namely contaminants, variant and megacomplexes, and transient interactions, and suggest that many of the novel shared components found in high‐throughput screens are neither the results of contamination nor central components, but appear to be primarily regulatory links in cellular processes. BioEssays 26:1333–1343, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This volume brings together contributions from distinguished scholars in the history of philosophy, focusing on points of interaction between discrete historical contexts, religions, and cultures found within the premodern period. The contributions connect thinkers from antiquity through the Middle Ages and include philosophers from the three major monotheistic faiths-Judaism, Islam, and Christianity. By emphasizing premodern philosophy's shared textual roots in antiquity, particularly the writings of Plato and Aristotle, the volume highlights points of cross-pollination between different schools, cultures, and moments in (...) premodern thought. Approaching the complex history of the premodern world in an accessible way, the editors organize the volume so as to underscore the difficulties the premodern period poses for scholars, while accentuating the fascinating interplay between the Greek, Hebrew, Arabic, and Latin philosophical traditions. The contributors cover many topics ranging from the aims of Aristotle's cosmos, the adoption of Aristotle's Organon by al-Farabi, and the origins of the Plotiniana Arabica to the role of Ibn Gabirol's Fons vitae in the Latin West, the ways in which Islamic philosophy shaped thirteenth-century Latin conceptions of light, Roger Bacon's adaptation of Avicenna for use in his moral philosophy, and beyond. The volume's focus on "source-based contextualism" demonstrates an appreciation for the rich diversity of thought found in the premodern period, while revealing methodological challenges raised by the historical study of premodern philosophy. Contextualizing Premodern Philosophy: Explorations of the Greek, Hebrew, Arabic, and Latin Traditions is a stimulating resource for scholars and advanced students working in the history of premodern philosophy. (shrink)

The case for an eco-emancipatory politics to release the Earth from human domination and free us all from lives that are both exploitative and exploited Human domination of nature shapes every aspect of our lives today, even as it remains virtually invisible to us. Because human beings are a part of nature, the human domination of nature circles back to confine and exploit people as well—and not only the poor and marginalized but also the privileged and affluent, even in the (...) world’s most prosperous societies. Although modern democracy establishes constraints intended to protect people from domination as the arbitrary exercise of power, it offers few such protections for nonhuman parts of nature. The result is that, wherever we fall in human hierarchies, we inevitably find ourselves both complicit in and entrapped by a system that makes sustainable living all but impossible. It confines and exploits not only nature but people too, albeit in different ways. In Eco-Emancipation, Sharon Krause argues that we can find our way to a better, freer life by constraining the use of human power in relation to nature and promoting nature’s well-being alongside our own, thereby releasing the Earth from human domination and freeing us from a way of life that is both exploitative and exploited, complicit and entrapped. Eco-emancipation calls for new, more-than-human political communities that incorporate nonhuman parts of nature through institutions of representation and regimes of rights, combining these new institutional arrangements with political activism, a public ethos of respect for nature, and a culture of eco-responsibility. (shrink)

Nothing seems more possible to me than that people some day will come to the definite opinion that there is no copy in the… nervous system which corresponds to a particular thought, or a particular idea, or, memory.WittgensteinIn a recent essay it was emphasized that brain and mind appear to the mind as complementary and reciprocally recursive domains of a hermeneutic circle (Fischer, 1987). An outstanding and not yet recognized feature of this hermeneutic circle is that interpretation within this circle (...) is not rule-governed and hence appears self-organized: individual features of the world (or the brain) become intelligible in terms of the whole context (of the mind)… while the entire context becomes intelligible through individual features (or brain functions). How, or from where then is significance arising? (shrink)

This article aims to contribute to a critical ontology of social objects. Recent works on collective intentionality and norm-following neglect the question how free agents can be brought to collectively intend to x , although x is not in their own interest. By arguing for a natural disposition to empathic understanding and drawing on recent research in the neurosciences, this article outlines an ontological framework that extends collective intentionality to questions of oppression and status asymmetries. In a contribution to this (...) journal, Wisnewski (2005) unfortunately mischaracterizes the problem of meaning in social criticism. Implementing status problems in studies of collective intentions and construing social facts as both subjective and objective in character helps explain why agents can have persistent "misunderstandings" of social objects. (shrink)

Die Frühschriften Nietzsches bilden eine deutlich abgrenzbare Abteilung des Gesamtwerks. Den Bruch im Fortgang zu den aphoristischen Hauptwerken (Menschliches, Allzumenschliches usf.) zu erklären beansprucht die vorliegende Arbeit. Mit Hilfe von Methoden der Analytischen Philosophie rekonstruiert sie ein utopisches Argument, dessen notwendiges Scheitern sie als erklärende Hypothese entwickelt und propagiert.