This review deals with the condensation–decondensation cycle of chromatin. This cycle can be analysed in increasing detail because of the availability of well‐characterized temperature‐sensitive cell‐cycle mutants in which the control for condensation is aberrant at the non‐permissive temperature. DNA transfection and gene cloning techniques using one such mutant have resulted in the identification of a gene involved in the normal regulation of entry into mitosis.

I consider a situation in which workers have present-biased preferences and tend to procrastinate their tasks, but underestimate the degree of self-control problems that they will face in the future. Brocas and Carrillo show that a form of competition always mitigates delay in a setting where agents are perfectly aware of their future self-control problems. However, I show that the introduction of the competition considered in their paper does not necessarily mitigate delay in a setting where agents underestimate the magnitude (...) of their future self-control problems. The intuition is that competition reinforces their belief that they will complete earlier, which undermines their incentive to complete now. This result holds even when there is only one worker who severely underestimates the degree of his or her future self-control problem, suggesting that the mere existence of a single “irrational” agent can undermine the overall performance of organizations. Moreover, the intuition behind my result implies that, to mitigate procrastination, it is important to design schemes in which workers believe that they will not complete early in the future, e.g., reducing competition over time, increasing cost over time, or even enforcing no work day tomorrow. (shrink)

近代日本が抱える「文明」と「独立」の矛盾を、最も鋭く直視した福沢。彼の原点=蘭学に着目し、新しい思想が誕生する瞬間を描く。.

To preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white matter; however, this method can only map the “focal” functions and cannot monitor large-scale cortical networks in real-time. Recently, an in vivo electrophysiological method using cortico-cortical evoked potentials induced by single-pulse electrical cortical stimulation has been developed in an extraoperative setting. By (...) using the CCEP connectivity pattern intraoperatively, mapping and real-time monitoring of the dorsal language pathway is available. This intraoperative CCEP method also allows for mapping of the frontal aslant tract, another language pathway, and detection of connectivity between the primary and supplementary motor areas in the frontal lobe network. Intraoperative CCEP mapping has also demonstrated connectivity between the frontal and temporal lobes, likely via the ventral language pathway. Establishing intraoperative electrophysiological monitoring is clinically useful for preserving brain function, even under general anesthesia. This CCEP technique demonstrates potential clinical applications for mapping and monitoring large-scale cortical networks. (shrink)