Alzheimer's disease (AD) is a neurodegenerative disease exhibiting amyloid beta (Aβ) peptide accumulation as a key characteristic. Autophagy, which is dysregulated in AD, participates in the metabolism of Aβ. Unexpectedly, we recently found that autophagy, in addition to its degradative function, also mediates the secretion of Aβ. This finding adds Aβ to an increasing number of biomolecules, the secretion of which is mediated by autophagy. We also showed that inhibition of Aβ secretion through genetic deletion of autophagy leads to intracellular (...) Aβ accumulation, which enhanced neurodegeneration induced by autophagy deficiency. Hence, autophagy may play a central role in two pathological hallmarks of AD: Aβ amyloidosis and neurodegeneration. Herein, we summarize the role of autophagy in AD with focus on Aβ metabolism in light of the recently established role of autophagy in protein secretion. We discuss potential routes for autophagy‐mediated Aβ secretion and suggest experimental approaches to further elucidate its mechanisms. (shrink)

This article is an analysis of the recognition of the Missionary Church of Kopimism as a faith community by the Swedish state. The analysis draws on post-Foucaultian writings on governmentality and seeks to understand what kind of normative and proscriptive understandings of “religion” guide the process. The authors argue that the recognition reveals fundamental aspects of the Swedish state’s performative role in the recognition of faith communities which challenges any unreflective classification of it as “secular.”.

During the last decade, the populist radical nationalist party, the Sweden Democrats, has gone from being a minor party to become Sweden’s third largest party in parliament. In this article, the author shows how the category of Christianity has come to play a pivotal role in the party’s political identification. Drawing on Ernesto Laclau’s analysis of populism, the author argues that Christianity should be understood as a projection surface for fantasies of an ethnically and culturally superior homogenous nation vis-à-vis constructed (...) national others. In a populist logic, Christianity has thus become a way to distinguish the SD from its articulated external and internal political foes. By appropriating Christianity, the SD articulates itself as the guardian of true Christianity, the future savior of a Church allegedly hijacked by external and internal foes, and in the long run, the Swedish nation. (shrink)