Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fata decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)→Ras→mitogen activated protein kinase (MAPK) cascade and one that involves a LIN‐12/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that (...) control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK→Ras→MAPK cascade involved in vulval induction. (shrink)

本书以唯物主义和进化观点对客观存在、主观存在、现实存在等各种存在形态进行考察,揭示了它们之间的内在进化规律.

Di 1 juan. Ren lei di ben zhi: dong wu + wen hua. -- di 2 juan. Ren lei di zu he: cong ge ti, qun ti dao zheng ti. -- di 3 juan. Ren lei di huan jing: zi ran yu wen hua. -- di 4 juan. Ren lei di jie ju: i ge quan xin di shi jie.

From the perspectives of manager cognition and behavior selection, this paper analyzes the cognitive basis of manufacturer’s green innovation and discovers that the embodied cognition of the manager has an important influence on the selection of green innovation behavior. Next, the behavior activation in the four stages of manufacturer’s green innovation, namely, initiation, termination, change, and solidification, was analyzed, and two behavior selections were proposed: the adaptive legitimacy with institutional logic as the cognitive starting point and the strategic legitimacy with (...) efficiency logic as the cognitive starting point. On this basis, the authors examined four types of manufacturer decisions of green innovation driven by manager cognition and behavior selection. The examination reveals how should the manager, facing the growing environmental pressure, form a correct cognition, select the right behavior, and make the proper green innovation decision, which promotes the green, sustainable development of manufacturers. (shrink)

Putting subjectivity back in psychology and in social sciences is the aim of this volume. Subjectivity is a core psychological dimension but frequently forgotten. Without a full understanding of the uniqueness of each human life our understanding of psychological life fails to reach its aim. This book explores precisely the field of subjectivity, offering the reader different and innovative views on this challenging theme. This book is an asset for all those interested in understanding how the mind operates as a (...) subjectifying process and how this subjectifying mind is simultaneously the product and the content of feeling an unique and unrepeatable subjective life. By bringing together renowned and emergent experts in the field, it provides a fresh new look on the human mind. The reader will find thought-provoking and challenging contributions of 26 different scholars, from 10 countries. It covers a wide range of perspectives and approaches, such as dialogical perspectives, cultural psychology approaches, developmental psychology, feminist perspectives, semiotics, and anthropology. This volume will be very much recommended for all sorts of scholars and students in social and human sciences interested in the human mind and in subjectivity. It will be adequate for different levels of teaching, from undergraduate to master courses. It also meant to be understood for all readers interested in the topic. (shrink)

The lifetime prevalence of major depressive disorder in adolescents is reported to be as high as 20%; thus, MDD constitutes a significant social and public health burden. MDD is often associated with nonsuicidal self-injury behavior, but the contributing factors including cognitive function have not been investigated in detail. To this end, the present study evaluated cognitive impairment and psychosocial factors in associated with MDD with NSSI behavior. Eighteen and 21 drug-naïve patients with first-episode MDD with or without NSSI and 24 (...) healthy control subjects were enrolled in the study. The Hamilton Anxiety Scale, Hamilton Depression Scale, Adolescent Self-injury Questionnaire, Beck Scale for Suicide Ideation–Chinese Version, Shame Scale for Middle School Students, Sensation Seeking Scale and Childhood Trauma Questionnaire were used to assess depression-related behaviors, and event-related potentials were recorded as a measure of cognitive function. The latency of the N1, N2, P3a, P3b, and P50 components of ERPs at the Cz electrode point; P50 amplitude and P50 inhibition showed significant differences between the 3 groups. CTQ scores also differed across three groups, and the NSSI– and NSSI+ groups showed significant differences in scores on the Shame Scale for Middle School Students. Thus, cognitive function was impaired in adolescents with MDD with NSSI behavior, which was mainly manifested as memory decline, attention and executive function deficits, and low anti-interference ability. We also found that childhood abuse, lack of social support, and a sense of shame contributed to NSSI behavior. These findings provide insight into the risk factors for MDD with NSSI behavior, which can help mental health workers more effectively diagnose and treat these patients. (shrink)