Patients with advanced Alzheimer's disease experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD underwent (...) surgery for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale–Cognitive Subscale showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.Clinical Trial Registration: ChiCTR1900022324. (shrink)

Viennese Brain Research and the Formation of Austrian Positivism. In this paper, I want to argue that the Vienna School of Medicine and especially the Viennese Brain Anatomy had an impact on the formation of the Austrian positivism. I argue that Carl von Rokitansky's (1804–1878) doctrine that psychological phenomena must be translated into anatomical facts and Theodor Meynert's (1833–1892) theory of brain functions served as one basis for the formation of the Austrian positivism. In this sense, two of the (...) main early positivistic thinkers, Ernst Mach (1838–1916) and Richard Wahle (1857–1935), used Meynert's brain theory to argue for a bundle view of the Self. Friedrich Jodl (1849–1914) also thought about his theory, and even Moritz Schlick (1882–1936) who demanded a ‘reduction of the psychology to the brain physiology’ grappled with this approach. Meynert, a scholar of Rokitansky, the founder of the Vienna School of Medicine, was a leading figure in the history of neurology and has made several significant contributions to this discipline. He argues that the Self does not exist from an anatomical point of view. As Richard Wahle tells us, Meynert's theory of the brain functions was widely accepted under the brain researchers by the end of the nineteenth century and at the beginning of the twentieth century. He makes clear that brain researchers did in common refer to Meynert's theory to explain psychical functions as brain functions. He says from their point of view there was no doubt about it. Mach talks about Meynert's theory in Erkenntnis und Irrtum. There he says that Meynert's brain theory explains the nature and conditions of the consciousness. Michael Hagner argues that Mach's “Das Ich ist unrettbar” is hardly imaginable without the cerebral embedding of the mental functions. (shrink)