Plasma protein therapies are a group of essential medicines extracted from human plasma through processes of industrial scale fractionation. They are used primarily to treat a number of rare, chronic disorders ensuing from inherited or acquired deficiencies of a number of physiologically essential proteins. These disorders include hemophilia A and B, different immunodeficiencies and alpha 1-antitrypsin deficiency. In addition, acute blood loss, burns and sepsis are treated by PPTs. Hence, a population of vulnerable and very sick individuals is dependent on (...) these products. In addition, the continued well-being of large sections of the community, including pregnant women and their children, travelers and workers exposed to infectious risk is also subject to the availability of these therapies. Their manufacture to adequate amounts requires large volumes of human plasma as the starting material of a complex purification process. Mainstream blood transfusion services run primarily by the not-for-profit sector have attempted to provide this plasma through the separation of blood donations, but have failed to provide sufficient amounts to meet the clinical demand. The collection of plasma from donors willing to commit to the process of plasmapheresis, which is not only time consuming but requires a long term, continuing commitment, generates much higher amounts of plasma and has been an activity historically separate from the blood transfusion sector and run by commercial companies. These companies now supply two-thirds of the growing global need for these therapies, while the mainstream government-run blood sector continues to supply a shrinking proportion. The private sector plasmapheresis activity which provides the bulk of treatment products has been compensating the donors in order to recognize the time and effort required. Recent activities have reignited the debate regarding the ethical and medical aspects of such compensation. In this work, we review the landscape; assess the contributions made by the compensated and non-compensated sectors and synthesize the outcomes on the relevant patient communities of perturbing the current paradigm of compensated plasma donation. We conclude that the current era of “Patient Centeredness” in health care demands the continuation and extension of paid plasma donation. (shrink)

Many global and national systems of regulation of blood donors and donor compensation rely for intellectual support on Richard Titmuss’s views, represented in The Gift Relationship. Based on selective interpretation of data from the 1960s, Titmuss engineered an ethical view pertaining to donors and, in so doing, created not only ongoing stereotypes, but created a cause for followers to perpetuate misunderstandings about the nature of such donations. In many cases, donors are, in fact compensated, but regulatory systems persevere in using (...) definitional fig leaves in order to perpetuate an ongoing political goal of diminishing private sector participation in health care. However, in more recent works, including new views of critical sociology and evolutionary psychology, the Titmuss worldview has been turned upside-down. Evidence readily available today proves the safety of compensated donation and the lives saved by encouraging policies for both compensated and non-compensated donation. (shrink)

Neuromarketing is the use of imaging technology to ascertain information about brain states during the viewing of advertising and products. It is an area of increasing interest for the purposes of both neuroscience brain research and marketing. At present, there remains significant disagreement about value of knowledge claims made by neuromarketing and its efficacy in both understanding and predicting consumer behavior. This paper outlines an approach to epistemic conception of neuromarketing by applying and broadening the categories of technological knowledge produced (...) by Walter Vincenti and Marc de Vries. Categories of technological knowledge capture several important elements of epistemology and knowledge generation, though more work in areas such as business judgment and knowledge translation remains to be done. The framework provided herein presents new epistemological considerations for the analysis of marketing practice related consumer behavior and brain activity. (shrink)

Neuromarketing is the use of imaging technology to ascertain information about brain states during the viewing of advertising and products. It is an area of increasing interest for the purposes of both neuroscience brain research and marketing. At present, there remains significant disagreement about value of knowledge claims made by neuromarketing and its efficacy in both understanding and predicting consumer behavior. This paper outlines an approach to epistemic conception of neuromarketing by applying and broadening the categories of technological knowledge produced (...) by Walter Vincenti and Marc de Vries. Categories of technological knowledge capture several important elements of epistemology and knowledge generation, though more work in areas such as business judgment and knowledge translation remains to be done. The framework provided herein presents new epistemological considerations for the analysis of marketing practice related consumer behavior and brain activity. (shrink)