This hypothesis is that anorexia nervosa is a biologically driven disorder, and mammalian hibernation may offer clues to its pathogenesis. Using this approach, this hypothesis offers suggestions for employing heart rate variability as an early diagnostic test for anorexia nervosa; employing the ketogenic diet for refeeding patients, attending to omega 3:6 ratio of polyunsaturated fatty acids in the refeeding diet; and exploring clinical trials of the endocannabinoid-like agent, palmitoylethanolamde for patients with anorexia nervosa. This hypothesis also explores the role (...) of lipids and autoimmune phenomena in anorexia nervosa, and suggest a lipodomics study to search for antibodies in the serum on patients with anorexia nervosa. (shrink)

Mammalian hibernation is characterized by profound reductions in metabolism, oxygen consumption and heart rate. As a result, the animal enters a state of suspended animation where core body temperatures can plummet as low as −2.9°C. Not only can hibernating mammals survive these physiological extremes, but they also return to a normothermic state of activity without reperfusion injury or other ill effects. This review examines recent findings on the genes, proteins and small molecules that control the induction and maintenance of (...) hibernation in mammals. The molecular events involved with remodeling metabolism, inducing hypothermia and maintaining organ function are discussed and considered with respect to analogous processes in non‐hibernating mammals such as mice and humans. The advent of sequenced genomes from three distantly related hibernators, a bat, hedgehog and ground squirrel, provides additional opportunities for molecular biologists to explore the mechanistic aspects of this biological adaptation in greater detail. BioEssays 29:431–440, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Beginning in the mid-1930s the comparative physiologists Laurence Irving and Per Fredrik Scholander pioneered the study of diving mammals, particularly harbor seals. Although resting on earlier work dating back to the late nineteenth century, their research was distinctive in several ways. In contrast to medically oriented physiology, the approaches of Irving and Scholander were strongly influenced by natural history, zoology, ecology, and evolutionary biology. Diving mammals, they argued, shared the cardiopulmonary physiology of terrestrial mammals, but evolution had modified these basic (...) adaptive processes in extreme ways. In particular, seals’ remarkable ability to hold breath, lower metabolism, produce energy anaerobically, and resist asphyxiation, provided a sharp contrast with terrestrial mammals, including humans. This diving physiology was an extreme elaboration of a general regulatory mechanism that allowed seals and other diving mammals to remain active underwater for extended periods. The decrease in heart rate referred to as bradycardia or the “diving reflex” was highly developed in diving mammals, but also found in less developed form in many other organisms faced by asphyxia. It therefore served as a kind of “master switch” for lowering metabolism in diving, hibernation, parturition, drowning, and other physiological responses involving lack of oxygen. Studying bradycardia unified a wide diversity of physiological phenomena, while also providing a context for contrasting the physiological responses of various species, including humans. Conducted in the laboratory and the field, this research served as a bridge between a comparative physiological ecology focused on non-human species and a human-centered general physiology. (shrink)

I will describe two non-standard ways of thinking about time. The first is ubiquitous in animal cognition. I will call it ‘phase time’. Suppose for example you consider a hibernating animal. This animal might have representation of the various seasons of the year, and modulate its actions dependent on the season. But it need have no distinction between the winter of one year and the winter of another; it thinks of time only in terms of repeatable phases.

The thesis concerning the totalitarian character of the Enlightenment was originally articulated, if only briefly, during the heyday of the California exile of the Institute for Social Research, then suddenly dropped. Dialectic of Enlightenment was never completed and it was around that time, the mid-1940s, that Critical Theory went into its notorious theoretical hibernation. As Nancy Jachec shows in “Adorno, Greenberg and Modernist Politics,” the next two decades were wasted on forays into aesthetics, psychoanalysis and opportunistic liberal apologetics such (...) as The Authoritarian Personality — nothing radically different from what run-of-the-mill liberal ideologues such as Clement Greenberg were also doing. (shrink)

Human services planning for crews who go to Mars is in its earliest phase, but the modalities for service delivery are well worth anticipating because they could involve some of the first innovations that merge physical, biological, and digital capacities on the new planet. This chapter examines the constraints of the planet Mars, itself, on all humans. It anticipates how “exogenous stressors” might affect the psychological, social, and cultural capacities and conflicts of the earliest crews. Several types of service modalities (...) are explored: hibernation; medication management; traditional psychotherapy; long-distance modalities to approximate the “talking cure”; digitized, keyed psychology workbooks; robotics, or service delivery without verbal feedback; AI technologies, or service delivery with verbal feedback; problem-solving at the cultural level; digital bulletin boards to substitute for journaling; and a special section on the issue of privacy. The chapter rounds out with a section, on types of spiritual services that may be beneficial even for those who profess no faith. We focus on “sacred space,” and on death and burial ritual on Mars. Factors explored here reflect the backgrounds of the two authors: one, a cultural anthropologist and biologist, and the other, an astronomer who is also a Catholic priest. (shrink)

In philosophy, old theories never die, they just hibernate. For many years, no philosophical approach could have been more out of date than that of the British Hegelians: Green, Bradley, and Bosanquet. No theory has been “refuted” more often than their coherence account of truth, both as a definition of truth and as a criterion of truth. Coherence did enjoy a brief renaissance during the early days of logical positivism. Neurath put forth such an account. Carnap, during one of his (...) many periods, came under the influence of Neurath’s brand of physicalism and Carl Hempel defended the coherence view against the criticisms of Schlick, among others. (shrink)

Extreme loss of skeletal muscle mass (atrophy) occurs in human muscles that are not used. In striking contrast, skeletal muscles do not rapidly waste away in hibernating mammals such as bears, or aestivating frogs, subjected to many months of inactivity and starvation. What factors regulate skeletal muscle mass and what mechanisms protect against muscle atrophy in some species? Severe atrophy also occurs with ageing and there is much clinical interest in reducing such loss of muscle mass and strength (sarcopenia). In (...) the meat industry, a key aim is optimizing the control of skeletal muscle growth and meat quality. The impaired response of muscle to insulin resulting in diabetes, that is a consequence of the metabolic impact of increasing obesity and fat deposition in humans, is also of increasing clinical concern. Intensive research in these fields, combined with mouse models, is reviewed with respect to the molecular control of muscle growth (myogenesis) and atrophy/hypertrophy and fat deposition (adipogenesis) in skeletal muscle, with a focus on IGF‐1/insulin signaling. BioEssays 28: 994–1009, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Empirical studies suggest that re-corruption is a common occurrence in developing countries, and we know little about what transpires between corruption and re-corruption. The objective of this empirical study is to discuss the practices of government officers in between phase of corruption and re-corruption. It does so by considering the case of a government officer working in an agricultural marketing yard of India. The findings from the case suggest that officers choose to mimic honest dispositions after their transfers to new (...) postings as it gives them more choices in the practice of corruption. The hibernation model of re-corruption is used to explain this behavior of the officers. The study is critical and inspired by Pierre Bourdieu’s theory of practice. The findings from it will directly contribute to the design of anti-corruption policies. (shrink)

It might seem counterintuitive to think transhumanists, who are typically characterized by extreme techno-optimism and hope for radical life-extension, would be interested in assisted dying. Because the technological enhancements they long for will probably not be available during their natural lifetimes, many transhumanists at least entertain the idea of having themselves cryonically preserved to buy some additional time for real-world technology to catch up to their dreams. However, since an ideal preservation would take place before serious cellular deterioration sets in, (...) controlling the time and manner of death would be very attractive for transhumanist cryonicists. This chapter identifies some circumstances under which they might be justified in seeking assistance in dying (even though they would describe it as something more akin to hibernating). After providing a fundamental overview of both transhumanism and cryonics, and then making my case for what some scholars have called “cryothanasia” (i.e. assisted dying for the purpose of improved preservation quality), I proceed to consider some scenarios meant to test the limits of this justification. While things are admittedly murkier when considering the possibility of cryothanasia outside the context of imminent medical collapse, I can see no insurmountable criticisms of cryothanasia as a last resort in cases of (currently) terminal and irreparable neurodegeneration or other forms of progressive brain damage. (shrink)

Le printemps austral au Chili a été le théâtre d’un grand soulèvement qui a mis fin à la politique néolibérale de Piñera tout en critiquant le cadre constitutionnel, héritage de l’époque Pinochet. Au départ, le mouvement était une grève métropolitaine contre l’augmentation du prix du ticket des transports publics. Face à la répression qui a suivi la grève s’est transformée en un soulèvement des multitudes pour la démocratie et un nouveau système de protection sociale. Même les tentatives de médiation institutionnelles (...) ne semblent ne pas avoir de succès pour bloquer le mouvement qui tout de même rentre en hibernation à cause de la pandémie. Mais le résultat du plébiscite pour une nouvelle constituante qui montre que le pays s’émancipe du cadre pinochetiste. (shrink)

What happened to the doctrine of natural right in the nineteenth century? We know that it flourished in the seventeenth and eighteenth centuries. We know that something like it - the doctrine of human rights and new forms of social contract theory - flourished again in the second half of the twentieth century and continues to flourish in the twenty-first. In between there was a period of decline and hibernation - uneven, to be sure, and never complete - but (...) a period in which to invoke natural right was always to invite intellectual ridicule and accusations of political irresponsibility. Thus article asks: How far can the decline of natural right in the nineteenth century be attributed to the reaction against the revolution in France? How far it was the effect of independent streams of thought, like positivism and historicism? Why was radical thought so ambivalent about natural right throughout the nineteenth century, and why was socialist thought in particular inclined to turn its back on i? As a framework for thought, natural right suffered a radical decline in the social and political sciences. But things were not so clear in jurisprudence, and natural right lived on to a much riper old age in the writings of some prominent economists. So we have to ask: What is it about this theory that allowed it to survive in these environments, when so much of the rest of intellectual endeavor in the nineteenth century was toxic or inhospitable to it. Finally, I shall ask how far American thought represents an exception to all of this. Why and to what extent did the doctrine survive as a way of thinking in the United States, long after it had lost its credibility elsewhere. (shrink)

Some real objects show a very particular tendency: that of becomingindependent with regard to the uncertainty of their surroundings. This isachieved by the exchange of three quantities: matter, energy andinformation. A conceptual framework, based on both Non-equilibriumThermodynamic and the Mathematical Theory of Communication is proposedin order to review the concept of change in living individuals. Three mainsituations are discussed in this context: passive independence inconnection with resistant living forms (such as seeds, spores, hibernation,...), active independence in connection with the (...) life span of aliving individual (whether an ant or an ant farm), and the newindependence in connection with the general debate of biological evolution. (shrink)