The aim of this contribution is to provide a few historical and conceptual insights on the question of the impact of current developments in the neurosciences on the concept of psychiatric disease. Alzheimer’s disease is a good example when considering this important question. On the one hand, Alzheimer’s disease has a somewhat ambiguous status in terms of disorders affecting the mind or the psyche. This ambiguous status is illustrated by the fact that one commonly qualifies Alzheimer’s disease as a ‘neuropsychiatric’ (...) disorder, because it cannot easily be classified as either a ‘neurological’ or ‘psychiatric’ disorder. On the other hand, the concept of Alzheimer’s disease was created at the beginning of the twentieth century, as the neurosciences were beginning to take shape themselves as scientific disciplines. To compare Alzheimer’s original ideas with current conceptions may thus help us to precisely specify current developments in the neurosciences. (shrink)