Regeneration in arthropods and amphibians follows an analogous principle making comparisons between the two phyla possible.Larval arthropods and amphibians possess powers of epimorphic regeneration which wane for many species of these phyla with the completion of metamorphosis or the cessation of moulting. In those species which retain, post-maturationally, the ability to form a regenerative blastema, larval characteristics are carried into the adult and reproductive stages of these organisms. These include many species of: urodeles, ametabolous insects, crustaceans, myriapods and arachnids. The (...) long-standing distinction between embryonic regulation and true epimorphosis would thus appear to be a difference of degree rather than kind. (shrink)

We develop a general covariant categorical modeling theory of natural systems' behavior based on the fundamental functorial processes of representation and localization-globalization. In the second part of this study we analyze the semantic bidirectional process of localization-globalization. The notion of a localization system of a complex information structure bears a dual role: Firstly, it determines the appropriate categorical environment of base reference contexts for considering the operational modeling of a complex system's behavior, and secondly, it specifies the global compatibility conditions (...) of local contextual information. A localization system acts on the global information structure of a complex system, partitions it into sorts, and eventually, forces the consistent sheaf-theoretic fibering of the latter over the base category of commutative reference contexts. In this manner, the sheafification of the Spectrum functor of a complex information structure takes place by imposing on the uniform and homologous fibered structure of elements of the Spectrum presheaf the following two requirements of coherence in relation to the localization-globalization process: [i]. Compatibility of information under restriction from the global to the local level, and [ii]. Compatibility of information under extension from the local to the global level. Correspondingly, the options of local and global receive a concrete mathematical meaning with respect to a suitable notion of topology (categorical Grothendieck topology) defined on the base category of commutative reference contexts. Finally, the accurate functorial process modeling of a complex system's behavior, respecting the processes of representation and localization-globalization, is being effectuated by means of establishing a categorical dual equivalence between the category of complex information structures, and the topes of sheaves over the base category of partial or local information carriers, equipped with the categorical topology of epimorphosis families. (shrink)

Regeneration capabilities are found in most or all animals. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. If we consider regeneration as a process belonging to development, similarly to embryogenesis or metamorphosis, the existence of regenerative capabilities in adults can be seen as an argument in favor of the theory that development continues throughout the life of animals. Here I perform a comparative analysis of regeneration versus “classical” (...) developmental processes in animals in order to determine to what extent these processes are inclusive or distinct. I identify the existence of regeneration-specific processes, i.e., processes that occur during the regeneration, but not the initial development, of a given structure. In addition, I find that seemingly similar processes acting during development and regeneration may have differential molecular and cellular bases. I thus conclude that there are significant differences between regeneration processes in adult animals and developmental processes occurring during earlier phases of the life cycle. The existence of regenerative capabilities in adult animals can therefore not be used as an argument in favor of the idea that development spans the whole life. (shrink)

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration (1901). In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors. This essay probes into the history of (...) regeneration studies by looking in depth at Regeneration and evaluating Morgan's contribution. Although famous for his work with fruit fly genetics, studying Regeneration illuminates Morgan's earlier scientific approach which emphasized the importance of studying a diversity of organisms. Surveying a broad range of regenerative phenomena allowed Morgan to institute a standard scientific terminology that continues to inform regeneration studies today. Most importantly, Morgan argued that regeneration was a fundamental aspect of the growth process and therefore should be accounted for within developmental theory. Establishing important similarities between regeneration and development allowed Morgan to make the case that regeneration could act as a model of development. The nature of the relationship between embryogenesis and regeneration remains an active area of research. (shrink)