Biographical note: Jochen Golz, Goethe-Gesellschaft; Manfred Koltes, Goethe- und Schiller-Archiv an der Klassik Stiftung Weimar.

Ioannidis [Why most published research findings are false. PLoS Med 2: e124 ] identifies six factors that contribute to explaining why most of the current published research findings are more likely to be false than true, and argues that for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this article, we argue that three “hot” areas in current biological research, viz., agent-based modeling, evolutionary developmental biology , and systems biology, are (...) especially prone to the flaws. (shrink)

Biologists studying short-lived organisms have become aware of the need to recognize an explicit temporal extend of a population over a considerable time. In this article we outline the concept and the realm of populations with explicit spatial and temporary boundaries. We call such populations “temporally bounded populations”. In the concept, time is of the same importance as space in terms of a dimension to which a population is restricted. Two parameters not available for populations that are only spatially defined (...) characterise temporally bounded populations: total population size, which is the total number of individuals present within the temporal borders, and total residence time, which is the sum of the residence times of all individuals. We briefly review methods to estimate these parameters. We illustrate the concept for the large blue butterfly (Maculinea nausithous) and outline insights into ecological and conservation-relevant processes that cannot be gained without the use of the concept. (shrink)

The biological sciences have become increasingly reliant on so-called ‘model organisms’. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

What can the manifestations of schizophrenia and other mental disorders reveal about classical notions of philosophy such as thought, perception, self, and rationality? Philosophers, psychiatrists, and clinical psychologists got together to compare notes at Harvard in October 1989, and presented these 16 papers. Annotation copyrighted by Book News, Inc., Portland, OR.

Biology lacks a central organism concept that unambiguously marks the distinction between organism and non-organism because the most important questions about organisms do not depend on this concept. I argue that the two main ways to discover useful biological generalizations about multicellular organization—the study of homology within multicellular lineages and of convergent evolution across lineages in which multicellularity has been independently established—do not require what would have to be a stipulative sharpening of an organism concept.

Schizophrenia, like other pathological conditions of mental life, has not been systematically included in the general study of consciousness. By focusing on aspects of chronic schizophrenia, we attempt to remedy this omission. Basic components of Husserl’s phenomenology (intentionality, synthesis, constitution, epoche, and unbuilding) are explicated and then employed in an account of chronic schizophrenia. In schizophrenic experience, basic constituents of reality are lost and the subject must try to explicitly re-constitute them. “Automatic mental life” is weakened such that much of (...) the world that is normally taken-for-granted cannot continue to be so. The subject must actively re-lay the ontological foundations of reality. (shrink)

A procedure is given for the transformation of quantum mechanical operator equations into stochastic equations. The stochastic equations reveal a simple correlation between quantum mechanics and classical mechanics: Quantum mechanics operates with “optimal estimations,” classical mechanics is the limit of “complete information.” In this connection, Schrödinger's substitution relationsp x → -iħ ∂/∂x, etc, reveal themselves as exact mathematical transformation formulas. The stochastic version of quantum mechanical equations provides an explanation for the difficulties in correlating quantum mechanics and the theory of (...) relativity: In physics “time” is always thought of as a numerical parameter; but in the present formalism of physics “time” is described by two formally totally different quantities. One of these two “times” is a numerical parameter and the other a random variable. This last concept of time shows all the properties required by the theory of relativity and is therefore to be considered as the relativistic time. (shrink)