Philosophy of CRISPR-Cas: Introduction to Eugene Koonin’s target paper and commentaries

Biology and Philosophy 34 (1):16 (2019)
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Abstract

In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements and tolerate exogenous elements. We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.

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10.1007/s10539-018-9664-9

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Thomas Pradeu
CNRS & University Of Bordeaux

Citations of this work

Philosophy of immunology.Bartlomiej Swiatczak & Alfred I. Tauber - 2020 - Stanford Encyclopedia of Philosophy 2020.

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References found in this work

Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question.Eugene V. Koonin & Petro Starokadomskyy - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 59:125-134.

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