Abstract

In 2012, we published a computational automaton, based on the most comprehensive gene regulatory network (GRN) model yet available (Peter, Faure, and Davidson 2012). This model had been synthesized over the previous years from extensive experimental studies on specification mechanisms in the endomesodermal territories of the sea urchin embryo. The GRN model explicitly indicated the dynamically changing interactions occurring at the cis-regulatory control sequences of almost 50 genes, mostly encoding transcription factors (the proteins that specifically recognize cis-regulatory DNA sequence and cause expression or inactivity of the genes these sequences control). The GRN model encompasses all regulatory genes ..