Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted Igf2/H19 domain.1 The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling Igf2 to move between an active and a silent chromatin domain. The study (...) gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects. (shrink)

日本の戦後思想の核心とは、圧倒的な外来思想への、自己の戦争体験と近代日本の露わになった後進性を手がかりにした、ポストコロニアルな抵抗にある。非西洋世界が近代化にむけた苦闘にあるこのとき、日本の戦後思想 は、どのような可能性をもつのか。「リスク近代」の果てにせり上がってきた、世界が抱え込む「有限性」という概念を手がかりに、21世紀世界の思想的課題と、未来構想の可能性を問う。.

トリアージ、ワクチンの分配、ゲノム編集、さらに倫理、思想、文学、政治社会まで、様々な領域の喫緊の問題として「尊厳」を論じる。.

科学が自然を破壊した今、人間は人工的に反人工的な自然を保持するべく努力しなければなりません。科学技術は、この逆説に耐え抜かねばならないのでしょう。.

-- dai 4-5-kan. Saikontan -- dai 6-kan. Shin Saikontan -- dai 7-8-kan. Seiken igen -- dai 9, <11>-14-kan. Shōyōroku.

Kyosei, a traditional Japanese concept, has been applied to a variety subjects, from biology to business. It has more recently become synonymous with the concepts of corporate responsibility, ethical decision making, stakeholder maximization, and responsible reciprocity. The purpose of this paper is to trace kyosei's modern business application back to ancient Confucian thought. The ideals associated with Confucianism were instrumental in the creation of Japanese business codes of ethics during the early part of the seventeenth century. A short history of (...) this period is presented to provide a contextual framework for understanding these codes. A specific code of ethics, called the shuchu kiyaku, is presented for the first time in English and shown to have direct roots in Confucian writings. Statements from modern company codes and from modern Japanese and American businessmen are presented to reflect the philosophy of business embodied in that ancient code of ethics. (shrink)