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  1. Evolutionary medicine at twenty: rethinking adaptationism and disease. [REVIEW]Sean A. Valles - 2012 - Biology and Philosophy 27 (2):241-261.
    Two decades ago, the eminent evolutionary biologist George C. Williams and his physician coauthor, Randolph Nesse, formulated the evolutionary medicine research program. Williams and Nesse explicitly made adaptationism a core component of the new program, which has served to undermine the program ever since, distorting its practitioners’ perceptions of evidentiary burdens and in extreme cases has served to warp practitioner’s understandings of the relationship between evolutionary benefits/detriments and medical ones. I show that the Williams and Nesse program more particularly embraces (...)
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  • Normal and Abnormal Anxiety in the Age of DSM-5 and ICD-11.Dan J. Stein & Randolph M. Nesse - 2015 - Emotion Review 7 (3):223-229.
    Despite the effort on DSM-5 and ICD-11, few appear satisfied with these classification systems. We suggest that the core reason for dissatisfaction is expecting too much from them; they do not provide discrete categories that map to specific causes of disease, they describe clinical syndromes intended to guide treatment choices. Here we review work on anxiety and anxiety disorders to argue that while clinicians draw a pragmatic distinction between normal and abnormal emotions based on considerations such as severity and duration, (...)
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  • Law, Stigma, and Meaning: Implications for Obesity and HIV Prevention.Michael V. Stanton & Jason A. Smith - 2017 - Journal of Law, Medicine and Ethics 45 (4):492-501.
    Public health law has focused primarily on combatting stigma through laws targeting discrimination based on attributes, when the reach of stigma extends far beyond mere appearances. By exploring the lived experience of stigmatized individuals, policy makers might more deeply understand public health problems, more appropriately create health policies, and more effectively promote positive health behaviors. Efforts to address stigma must focus on all aspects of stigma to be effective.
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  • Why Disease Persists: An Evolutionary Nosology. [REVIEW]Robert L. Perlman - 2005 - Medicine, Health Care and Philosophy 8 (3):343-350.
    Although natural selection might be expected to reduce the incidence and severity of disease, disease persists. Natural selection leads to increases in the mean fitness of populations and so will reduce the frequency of disease-associated alleles, but other evolutionary processes, such as mutation and gene flow, may introduce or increase the frequency of these deleterious alleles. The pleiotropic actions of genes and the epistatic interactions between them complicate the relationship between genotype and phenotype, and may result in the preservation of (...)
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  • Research traditions and evolutionary explanations in medicine.Pierre-Olivier Méthot - 2011 - Theoretical Medicine and Bioethics 32 (1):75-90.
    In this article, I argue that distinguishing ‘evolutionary’ from ‘Darwinian’ medicine will help us assess the variety of roles that evolutionary explanations can play in a number of medical contexts. Because the boundaries of evolutionary and Darwinian medicine overlap to some extent, however, they are best described as distinct ‘research traditions’ rather than as competing paradigms. But while evolu- tionary medicine does not stand out as a new scientific field of its own, Darwinian medicine is united by a number of (...)
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  • Defining disease beyond conceptual analysis: an analysis of conceptual analysis in philosophy of medicine.Maël Lemoine - 2013 - Theoretical Medicine and Bioethics 34 (4):309-325.
    Conceptual analysis of health and disease is portrayed as consisting in the confrontation of a set of criteria—a “definition”—with a set of cases, called instances of either “health” or “ disease.” Apart from logical counter-arguments, there is no other way to refute an opponent’s definition than by providing counter-cases. As resorting to intensional stipulation is not forbidden, several contenders can therefore be deemed to have succeeded. This implies that conceptual analysis alone is not likely to decide between naturalism and normativism. (...)
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  • Is Psychopathy a Harmful Dysfunction?Marko Jurjako - 2019 - Biology and Philosophy 34 (5):1-23.
    In their paper “Is psychopathy a mental disease?”, Thomas Nadelhoffer and Walter Sinnott-Armstrong argue that according to any plausible account of mental disorder, neural and psychological abnormalities correlated with psychopathy should be regarded as signs of a mental disorder. I oppose this conclusion by arguing that at least on a naturalistically grounded account, such as Wakefield’s ‘Harmful Dysfunction’ view, currently available empirical data and evolutionary considerations indicate that psychopathy is not a mental disorder.
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  • Evolution, Dysfunction, and Disease: A Reappraisal.Paul E. Griffiths & John Matthewson - 2018 - British Journal for the Philosophy of Science 69 (2):301-327.
    Some ‘naturalist’ accounts of disease employ a biostatistical account of dysfunction, whilst others use a ‘selected effect’ account. Several recent authors have argued that the biostatistical account offers the best hope for a naturalist account of disease. We show that the selected effect account survives the criticisms levelled by these authors relatively unscathed, and has significant advantages over the BST. Moreover, unlike the BST, it has a strong theoretical rationale and can provide substantive reasons to decide difficult cases. This is (...)
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  • Diseases are Not Adaptations and Neither are Their Causes.Paul E. Griffiths & John Matthewson - 2020 - Biological Theory 15 (3):136-142.
    In a recent article in this journal, Zachary Ardern criticizes our view that the most promising candidate for a naturalized criterion of disease is the "selected effects" account of biological function and dysfunction. Here we reply to Ardern’s criticisms and, more generally, clarify the relationship between adaptation and dysfunction in the evolution of health and disease.
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  • Normality, Disease, and Enhancement.Theodore M. Benditt - 2007 - In Harold Kincaid & Jennifer McKitrick (eds.), Establishing medical reality: Methodological and metaphysical issues in philosophy of medicine. Springer. pp. 13-21.
    The vagueness or imprecision of ‘the normal’ allows it to be exploited for various purposes and political ends. It is conspicuous in both medicine and athletics; I am going to try to say something about the normal in each of these areas. In medicine the idea of the normal is often deployed in understanding what constitutes disease and hence, as some see it, in determining the role of physicians, in determining what is or ought to be covered by insurance, and (...)
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