Despite growing interest in Islamic bioethics, little work has been done on research ethics in Islam, and even less on animal research ethics. This essay explores religious and scientific insights into the lives of animals used as research subjects, particularly in Iran. The inner lives of animals and their relationship to their Creator as relayed by the Qur'an, ethological research on animal minds, and neuroethical reflection on painience are brought together to question the current, relatively unrestricted use of research animals (...) in Iran. The essay concludes that Islamic sources and the desire of Iranian clinicians to treat laboratory animals in line with them could poise Muslims to take the lead in developing alternatives to animal research. Further, recent suggestions that human and animal research guidelines and protections should be brought closer together are examined in light of these findings. (shrink)