This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects. Although their purely predictive/correlational use is important, it is this tracking feature that contributes to their potential usefulness in other applications, such as genetic dissection, and their use as controls, which allow us, indirectly, to "see" more clearly the role of environmental variables.

There is ample evidence that violations of injunctive norms impact ordinary causal attributions. This has struck some as deeply surprising, taking the ordinary concept of causation to be purely descriptive. Our explanation of the findings—the responsibility view—rejects this: we contend that the concept is in fact partly normative, being akin to concepts like responsibility and accountability. Based on this account, we predicted a very different pattern of results for causal attributions when an agent violates a statistical norm. And this pattern (...) has been borne out by the data. These predictions were based on the responsibility attributions that we would make. In this paper, I extend these previous findings, testing responsibility attributions. The results confirm the basis of our predictions, showing the same pattern of effects previously found for causal attributions for both injunctive norms and statistical norms. In fact, the results for responsibility attributions are not statistically significantly different from those previously found for causal attributions. I argue that this close correspondence lends further credence to the responsibility view over competing explanations of the impact of norms on causal attributions. (shrink)

The Culpable Control Model assumes that causal judgments are irrational: a negative evaluative reaction to an agent would lead individuals to overestimate his causal contribution to a harm. However, the extent to which these judgments deviate from criteria of rationality remains unclear. The two present studies aimed at investigating conditions under which this effect occurs. Participants red a vignette in which the evaluative reaction was operationalized through the agent’s motives (blameworthy, laudable). We also varied the causal link between the agent’s (...) action and the outcome (strong, weak, preempted). In both studies, we found that negative motives influenced causal judgments when a strong action-outcome link could be established. In Study 2, we replicated the effect of motives on causal judgment in the weak link condition. However, participants consistently judged the agent as less causal when the link was weak (vs. strong), regardless of the agent’s motives. These findings show that both the presence and the strength of the actual causal link between the action and the outcome moderate the detrimental effect of negative evaluative reactions on causal judgments. Thus, common sense causal judgments seem to deviate relatively little from the criteria of rationality. (shrink)