Enzymatic misrepair of ionizing‐radiation‐induced DNA damage can produce large‐scale rearrangements of the genome, such as translocations and dicentrics. These and other chromosome exchange aberrations can cause major phenotypic alterations, including cell death, mutation and neoplasia. Exchange formation requires that two (or more) genomic loci come together spatially. Consequently, the surprisingly rich aberration spectra uncovered by recently developed techniques, when combined with biophysically based computer modeling, help characterize large‐scale chromatin architecture in the interphase nucleus. Most results are consistent with a picture (...) whereby chromosomes are mainly confined to territories, chromatin motion is limited, and interchromosomal interactions involve mainly territory surfaces. Aberration spectra and modeling also help characterize DNA repair/misrepair mechanisms. Quantitative results for mammalian cells are best described by a breakage‐and‐reunion model, suggesting that the dominant recombinational mechanism during the G0/G1 phase of the cell cycle is non‐homologous end‐joining of radiogenic DNA double strand breaks. In turn, better mechanistic and quantitative understanding of aberration formation gives new insights into health‐related applications. BioEssays 24:714–723, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Scholars in the humanities and social sciences have turned to ethics to theorize politics in what seems to be an increasingly depoliticized age. Yet the move toward ethics has obscured the ongoing value of political responsibility and the vibrant life it represents as an effective response to power. Sounding the alarm for those who care about robust forms of civic engagement, this book fights for a new conception of political responsibility that meets the challenges of today's democratic practice. Antonio Y. (...) Vázquez-Arroyo forcefully argues against the notion that modern predicaments of power can only be addressed ethically or philosophically through pristine concepts that operate outside of the political realm. By returning to the political, the individual is reintroduced to the binding principles of participatory democracy and the burdens of acting and thinking as a member of a collective. Vázquez-Arroyo historicizes the ethical turn to better understand its ascendence and reworks Adorno's dialectic of responsibility to reassert the political in contemporary thought and theory. (shrink)

The ‘black box’ in Stoic axiology refers to the mysterious connection between the input of Stoic deliberation (reasons generated by the value of indifferents) and the output (appropriate actions). In this paper, I peer into the black box by drawing an analogy between Stoic and Kantian axiology. The value and disvalue of indifferents is intrinsic, but conditional. An extrinsic condition on the value of a token indifferent is that one's selection of that indifferent is sanctioned by context-relative ethical principles. The (...) value of an indifferent that does not meet this condition is normatively silenced, such that it fails to constitute a reason for action. (shrink)

Conscience – a catholic anthropological vision In the catholic tradition conscience always played an important role as visible in the ‘clausula Petri’ (Ac 5,30-33) or in Paul’s belief in its wisdom (Rm 2,14-16). Conscience can break rules (‘epikeia’), but should not stand up against the church as such. Luther’s historical deed left behind a distrust in conscience in the Catholic Church; it took 400 years to restore Paul’s vision of the conscience as the highest authority – if it is formed (...) and reaches the state of maturity. By his conscience, man is called to be as God created him; he is called by others to develop and to respect their dignity. He is also called by the world to form it according to its higher possibilities which cannot be realized but by man. Conscience is God’s voice in the person where his promises can be heard. Though conscience is free, it is the place where responsibility is formed according to what someone can and should do. This is why the conscience will keep its unavoidable and undeniable role – even in a postmodern context. (shrink)

Psychologists, as well as other mental health professionals, face unique demands in the workplace that create increased risk for burnout. This article discusses burnout prevalence and detection, including issues of complexity regarding diagnosis and assessment. An ethical lens is utilized to explore problems that may arise due to burnout, and the ethical responsibility of practicing self-care. Recommendations for graduate clinical training programs as well as practicing professionals are suggested, including strategies for monitoring self and others for warning signs of burnout (...) and implementing self-care. (shrink)

It has been pointed out that Sensorimotor Enactivism, a theory that claims that perception is enacted and brought about by movement, says very little about the neural mechanisms that enable perception. For the proponents of the predictive approach to Sensorimotor Enactivism, this is a challenge that can be met by introducing predictive processing into the picture. However, the compatibility between these theories is not straightforward. Firstly, because they seem to differ in their stand towards representations: while Sensorimotor Enactivism is said (...) to belong to the non-representational wing of cognitive science, predictive processing has a representational profile. And secondly, because they exhibit different explanatory strategies: while Sensorimotor Enactivism prioritizes the interactions of the embodied agent, predictive processing has internalist commitments. The aim of this paper is to address these concerns and show that a predictive approach to Sensorimotor Enactivism is viable. More specifically, I focus on the Free-Energy approach, a theory that falls within the ballpark of predictive processing. In this paper I argue for the following claims. I argue that both Sensorimotor Enactivism and the Free-Energy approach may be understood for some systems in representational terms. The non-representational reading of Sensorimotor Enactivism is not mandatory and neither is the representational reading of the Free-Energy approach. Sensorimotor Enactivism is, in this respect, compatible with both representational and non-representational interpretations of the FEA. So, the position towards representations of these frameworks should not stand in the way of a predictive approach to Sensorimotor Enactivism. I also show that the Free-Energy approach allows for an account that prioritizes the interaction of the embodied agent with the environment. This is the explanatory strategy followed by Sensorimotor Enactivism. To justify this strategy and following other proponents of Sensorimotor Enactivism, I argue that by referring to the interactions of the embodied agent a better account of the phenomena in question is provided. On this basis, I claim that Sensorimotor Enactivism and the Free-Energy approach are compatible in what concerns their explanatory strategy as well. Thus, making the case for the viability of the predictive approach to Sensorimotor Enactivism. (shrink)

Advocates of the ethical criticism of art claim that works' ethical defects or merits have an impact on their aesthetic value. Against ethical critics, autonomists claim that moral criteria should not be part of the considerations when evaluating works of art as art. Autonomism refers to the view that an artwork's aesthetic value is independent from its ethical value. The purpose of this paper is to examine how autonomism has been defended in the contemporary discussion in analytic aesthetics. I present (...) three versions of autonomism: Richard Posner's radical autonomism, James C. Anderson and Jeffrey T. Dean, and James Harold's moderate autonomism, and Francisca Pérez Carreño's robust autonomism. I argue that robust autonomism offers a stronger argument against the ethical critic. However, I point to some difficulties for Pérez Carreño's account and conclude by suggesting how further work in autonomism might go around them. (shrink)

Advocates of interactionism in the ethical criticism of art argue that ethical value impacts aesthetic value. The debate is concerned with “the intrinsic question”: the question of whether ethical flaws/merits in artworks’ manifested attitudes affect their aesthetic value (Gaut 2007: 9). This paper argues that the assumption that artworks have intrinsic ethical value is problematic at least in regards to a significant subset of works: fictional artworks. I argue that, insofar as their ethical value emerges only from attitudes attributable to (...) actual agents, fictional artworks only have extrinsic ethical value. I show that what is at stake for interactionism is whether ethical judgements concerning artists’ attitudes in a context, rather than manifested attitudes, are ever aesthetically relevant. I conclude that, without buying into extreme actual intentionalism, a still controversial theory of interpretation that ties artworks’ meaning to actual artists, interactionism fails to show that ethical flaws/merits are aesthetic flaws/merits. (shrink)

Advocates of interactionism in the ethical criticism of art argue that ethical value impacts aesthetic value. The debate is concerned with “the intrinsic question”: the question of whether ethical flaws/merits in artworks’ manifested attitudes affect their aesthetic value (Gaut 2007: 9). This paper argues that the assumption that artworks have intrinsic ethical value is problematic at least in regards to a significant subset of works: fictional artworks. I argue that, insofar as their ethical value emerges only from attitudes attributable to (...) actual agents, fictional artworks only have extrinsic ethical value. I show that what is at stake for interactionism is whether ethical judgements concerning artists’ attitudes in a context, rather than manifested attitudes, are ever aesthetically relevant. I conclude that, without buying into extreme actual intentionalism, a still controversial theory of interpretation that ties artworks’ meaning to actual artists, interactionism fails to show that ethical flaws/merits are aesthetic flaws/merits. (shrink)

Tirant son titre du prochain manifeste à paraître des deux auteurs, ce bref article met en relief la complicité intellectuelle entre Stefano Harney et Fred Moten au sein de nos sensibilités contemporaines. Il suggère quelques façons de les entendre dialoguer ensemble – entre eux, avec nous, parmi nous.

Decentralized biobanking “de-bi” applies blockchain technology and web3 values to embed the procedural principles of transparency, accountability, and inclusion into the biomedical research ecosyst...

Should nurses have their own ethics to match specific problems met in their daily routines? How do nurses act in a society that is changing from a 'monocultural' to an 'intercultural' structure? What are the ethical consequences of these changes for their many tasks? How can the ethical aspects be taught to nurses? This article describes the current status of nursing ethics in the curriculum taught in schools of higher education for nurses in The Netherlands. Aspects of the debate on (...) nursing ethics are outlined and ideas about its future as a subject and discipline in nurse education are offered. Est-ce que le personnel infirmier doit avoir son éthique à soi pour faire face aux problèmes spécifiques dans la routine journalière? Et comment les infirmiers/ères se comportent-ils dans une société qui est en train de changer de la 'monoculture' en 'interculture'? Quels sont les conséquences éthiques de leur tâches? Comment peuvent ces aspets éthiques être enseignés aux infirmiers/ères? Cet article parle de l'état courant de l'éthique infirmier dans l'enseignement dans les écoles de l'education supérieure pour infirmiers/ères en Hollande. En plus, il donne une esquisse de la discussion sur l'éthique infirmier et donne quelques idées pour le futur de l'éthique infirmier comme sujet et discipline en soi dans l'éducation des infirmiers/ères. Sollte das Pflegepersonal seine eigene Ethik haben um den spezifischen Problemen seiner täglichen Routine gewachsen zu sein? Wie soll das Pflegepersonal in einer Gesellschaft handeln, die im Wechsel ist von einer 'Monokultur' zu einer 'Interkultur'? Was sind die ethischen Konsequenzen ihres handeln? Wie können diese ethischen Aspekte dem Pflegepersonal gelehrt werden? Dieser Artikel beschreibt den gegenwärtigen Zustand der Krankenpflege-Ethik im Lehrplan der Schulen für Höhere Ausbildung für Pflegepersonal in Holland. Er gibt auch einen Umriss über die Debatte über Krankenpflege-Ethik und formuliert einige Ideen für die Zukunft der Krankenpflege- Ethik als ein Thema und eine Disziplin in der Ausbildung des Pflegepersonals. (shrink)

El presente trabajo propone analizar la manera en que Agustín de Hipona recepciona el pensamiento de Tertuliano, autor cristiano latino, también africano, del que lo separan unos 200 años. Las principales menciones al cartaginés tienen lugar en la crítica agustiniana a la concepción de la corporeidad del alma defendida por Tertuliano. A fin de poder analizar los argumentos y los conceptos filosóficos utilizados por el hiponense en el desarrollo de su crítica presentamos, en primer lugar, una breve introducción a Tertuliano (...) (c. 160- c. 220), deteniéndonos en algunos pasajes cruciales de su obra titulada _De anima_ (208/210). En segundo lugar, nos dedicamos a presentar y analizar la discusión que lleva adelante Agustín respecto de la tesis de la corporeidad del alma humana en _De Genesi ad litteram _(finalizado hacia el 415)_,_ y en _De anima et eius origine, _escrita posteriormente, entre 419 y 420. Evaluamos entonces la posición del hiponense respecto de la hipótesis traducionista sobre el alma humana, ciertamente vinculada al corporalismo defendido por Tertuliano. (shrink)

Most decision-making research in economics focuses on individual decisions. Yet, we know, from psychological research in particular, that individual preferences can be sensitive to social pressures. In this paper, we study the impact of a group environment on individual preferences for risky and ambiguous prospects. In our experiment, each participant was invited to make a series of lottery-choice decisions in two different conditions. In the Alone condition, individuals made private choices, whereas in the Group condition, individuals belonged to a three-person (...) group and group members’ choices were aggregated according to either a majority or unanimity rule. This design allows us to study the impact of a group environment on individuals’ attitude towards both risky and ambiguous prospects, while controlling for the decision rule used in the group. Our experimental results show that when individuals are in the Group condition, they tend to be less risk averse and more ambiguity averse than when they are not part of a group. Our experiment also suggests that the decision rule matters as it shows that these two trends tend to be stronger when the group implements a unanimity rule. Specifically, we found that individuals who belong to a group implementing a unanimity rule are significantly less risk averse than individuals who belong to a group that relies on the majority rule. We obtained a similar—but non-significant—result under ambiguity. (shrink)

Background: The prevalence of anxiety and depression in young students is associated with biosocial factors and scholastic stress. However, few studies have evaluated emotional-affective symptoms that are related to the immune system and antioxidant parameters in young individuals without diagnoses of affective disorders.Aim: This study aims to assess the relationship between emotional-affective symptoms and glutathione concentrations and CD4 and CD8 lymphocyte counts in college students.Methods: College students completed standardized psychometric instruments, including the Perceived Stress Scale, Hamilton Anxiety Scale, Beck Depression (...) Inventory, Familiar Social and Friends Support Scale, and Rosenberg Scale. Blood samples were biochemically analyzed. Analyses of variance were conducted between four groups according to symptom severity.Results: A considerable prevalence of stress, anxiety, and depression symptoms was observed and negatively correlated with self-esteem and socio-familiar support. Perceived stress was sexually dimorphic. Although biochemical parameters were within reference ranges, glutathione, CD4, and CD8 tended to be lower in participants with anxiety and depression symptoms, which may be of predictive value.Conclusion: The relationship between antioxidant/immune parameters and socio-affective scores is latent in undiagnosed college students who might develop affective disorders. The findings suggest that during the initial development of affective disorders, stress management strategies should be implemented to help college students cope with the academic load and monitor negative changes in their physiological state. (shrink)

Pasteur, théologien, philosophe cartésien et éditeur d’ouvrages spirituels, Pierre Poiret occupe un statut particulier et original dans l’histoire des idées religieuses : il incarne le rôle du « passeur spirituel », celui dont la mission est de transmettre à la postérité l’héritage des auteurs mystiques. Poiret n’est pas un mystique, mais un spécialiste de la « théologie mystique ». Mais qu’est-ce que le mot mystique désigne pour un protestant français du Refuge résidant en Hollande? Par quels moyens, selon Poiret, la (...) théologie mystique peut sortir de sa niche et s’adresser à un public élargi, toute confession confondue? Et encore, en quelle mesure son activité d’éditeur s’inscrit dans le cadre des querelles sur la mystique qui ont marqué la fin du xviie siècle? Telles sont les questions auxquelles cet article tentera de répondre. (shrink)

The McGurk illusion occurs when listeners hear an illusory percept, resulting from mismatched pairings of audiovisual speech stimuli. Hearing a third percept—distinct from both the auditory and visual input—has been used as evidence of AV fusion. We examined whether the McGurk illusion is instead driven by visual dominance, whereby the third percept, e.g., “da,” represents a default percept for visemes with an ambiguous place of articulation, like/ga/. Participants watched videos of a talker uttering various consonant vowels with and without audios (...) of/ba/. Individuals transcribed the CV they saw or heard. In the V-only condition, individuals predominantly saw “da”/“ta” when viewing CVs with indiscernible POAs. Likewise, in the AV condition, upon perceiving an illusion, they predominantly heard “da”/“ta” for CVs with indiscernible POAs. The illusion was stronger in individuals who exhibited weak/ba/auditory encoding. In Experiment2, we attempted to replicate these findings using stimuli recorded from a different talker. The V-only results were not replicated, but again individuals predominately heard “da”/“ta”/“tha” as an illusory percept for various AV combinations, and the illusion was stronger in individuals who exhibited weak/ba/auditory encoding. These results demonstrate that when visual CVs with indiscernible POAs are paired with a weakly encoded auditory/ba/, listeners default to hearing “da”/“ta”/“tha”—thus, tempering the AV fusion account, and favoring a default mechanism triggered when both AV stimuli are ambiguous. (shrink)

Disparities in maternal morbidity and mortality for Latinx populations are a paradigmatic example of the now widely acknowledged structural racism in U.S. health care that predisposed minorities to...

Aesthetic evaluations of human bodies have important implications for moral recognition and for individuals’ access to social and material goods. Unfortunately, there is a widespread aesthetic disregard for non-white bodies. Aesthetic evaluations depend on the aesthetic properties we regard objects as having. And it is widely agreed that aesthetic properties are directly accessed in our experience of aesthetic objects. How, then, might we explain aesthetic evaluations that systematically favour features associated with white identity? Critical race philosophers, like Alia Al-Saji, Mariana (...) Ortega, Paul C. Taylor, and George Yancy, argue that this is because the perception of racialized bodies is affected by the social structures in which they are appreciated. The aim of this paper is to propose how social structures can affect aesthetic perception. I argue that mental imagery acquired through the interaction with aesthetic phenomena structures the perception of non-aesthetic properties of bodies, so that aesthetic properties consistent with racist stereotypes are attributed to individuals. (shrink)

Søren Kierkegaard verweigert dezidiert die Standards akademischen Schreibens und betont die Unumgänglichkeit von "indirekter Mitteilung", wenn es um Glaubenswahrheit geht: Das Bemühen um stringente Argumentation und definitorisch gesicherte Termini führe zu Abstraktheit und Fixierung. Damit sei es indifferent gegenüber der einzigartigen und veränderlichen existentiellen Konstellation des Individuums. Kierkegaard geht es vielmehr darum, wie man die eigenständige, persönliche Sinnfindung des Gesprächspartners anregen kann, ohne dies durch die eigene Rede zu beeinflussen. Das Buch untersucht, welche sprachlichen und textuellen Maßnahmen diesem Programm geschuldet (...) sind. Mit Rekurs auf das Denken des theologisch weitgehend abstinenten Ludwig Wittgenstein wird deutlich, daß dieses Problem nicht nur religiöse Rede affiziert und daß das Ideal direkter Mitteilung fragwürdig ist. Es ergeben sich Konvergenzen zwischen den beiden Autoren, die bis in semiotische und epistemologische Implikationen reichen und den Unterschied zwischen Glauben und Wissen neu diskutieren lassen. (shrink)

La denominada “crisis ambiental” que advierte sobre los límites materiales del planeta ha dado lugar a una extensa producción teórica durante décadas. Producción que, como regla general, ha relegado la relectura de los textos clásicos de las ciencias sociales. El presente artículo rescata algunos debates contemporáneos relacionados con la lectura en clave ecológica de la obra de Marx. Obra que adquiere especial importancia al momento de comprender las formas que toma la explotación de la naturaleza bajo el sistema capitalista, problemática (...) resignificada en el marco de las discusiones actuales sobre sustentabilidad ambiental. (shrink)

The fragility of the subject is a recurring issue in the work of Anne Enright, one of Ireland's most remarkable and innovative writers. It is this specific interest, together with her attempt to make women into subjects, that inevitably links her work to Bracha Lichtenberg-Ettinger's theory of the matrixial borderspace, a feminine sphere that coexists with the Lacanian symbolic order and that, even before our entrance into this linguistic system, informs our subjectivity. By turning to a point in time before (...) language—the encounter between “self” and “other” during pregnancy—both Enright and Ettinger test the boundaries of and the gaps within the linguistic system. It is the going before language that ultimately enables both to go beyond some of the most persistent dualisms present within the linguistic system and to create room for an alternative—a feminine—understanding of the ethical relationality between self and other. (shrink)

Latin America is one of the most unequal continents in the world. This inequality translates into marked limitations in the possibilities of having a decent life for a high percentage of the population. Within the groups that are affected, women are undoubtedly even more so, because, in addition to shared economic and social inequalities with other vulnerable groups, they face discrimination based on gender. In Latin America, political protest has been undertaken by women who wish to denounce and abate the (...) injustices of which they are victims. These struggles have been analyzed by different thinkers. For the most part, feminist theories deal with the struggle of women against the oppressive behavior of patriarchy from the State or society. Others highlight the ability of women to contribute to social changes from socially accepted roles such as mothers, daughters, wives. These approaches ignore the difficulties experienced by female activists within the political mobilization. In this essay then we seek to document, analyze, and theorize about the patriarchal practices suffered by women activists - qua women- within the social organizations in Ciudad Juárez, as well as the forms of resistance they have opposed. (shrink)

Work in feminist and critical race aesthetics brings out a complex interaction between aesthetic, ethical, and political value. The interest in ethico-political considerations is also found in recent literature around art and ethics, such as debates about the work of immoral artists, cultural appropriation and heritage, and art in public spaces. These discussions are characterized by a social structural approach to the ethico-political value of art that focuses on relations between artworks, other artefacts, and individuals in specific sociohistorical contexts and (...) as they emerge from specific social organizations. In this paper I present the main features and assumptions behind these social structural approaches to the values of art. I examine accounts that take ethico-political value to depend on artworks’ contributions to public discourse and on their role in constituting social structures. (shrink)

The assumption in current U.S. mainstream medicine is that birthing requires hospitalization. In fact, while the American College of Obstetricians and Gynecologists supports the right of every birthing person to make a medically informed decision about their delivery, they do not recommend home birth owing to data indicating greater neonatal morbidity and mortality. In this article, we examine the evidence surrounding home birth in the United States and its current limitations, as well as the ethical considerations around birth setting.

RESUMENEn la obra del pensador gallego Francisco Sánchez (1551-1623), titulada Que nada se sabe, existen una serie de características que nos obligan a relacionarla directamente con el pensamiento judío. Entre estas cuestiones se hallan: las citas bíblicas recogidas por su autor, siendo la gran mayoría de ellas procedentes del Antiguo Testamento; la falta de la dedicatoria a la virgen María o la relación entre el alma y el cuerpo que recoge Sánchez y que es de claro origen judío.PALABRAS CLAVEESCEPTICISMO, PENSAMIENTO (...) JUDÍO, FRANCISCO SÁNCHEZABSTRACTIn the work of the thinker Francisco Sanchez (1551-1623), entitled That nothing is known, there are some characteristics that force us to directly relate it to the Jewish thought. Some of these questions are: the Biblical quotations gathered by its author, coming the great majority of them from the Old Testament; the lack of the dedication to Virgin Mary or the relation between the soul and the body that Sanchez shares with the Jewish tradition. All these topics point at the importance of this tradition in the work That nothing is known.KEYWORDSSCEPTICISM, JEWISH THOUGHT, FRANCISCO SANCHEZ, RENAISSANCE. (shrink)

ResumenEn el marco intelectual del Renacimiento hubo una serie de pensadores que se mostraron disconformes con el aristotelismo dominante. La variedad de sus posturas así como lo distinto de sus posicionamientos filosóficos ha podido actuar como obstáculo para poder ver las similitudes que, en torno a la crítica aristotélica, presentan. El caso de Juan Luis Vives y de Gianfrancesco Pico puede resultar paradigmático, a estos se suma con fuerza Francisco Sánchez, quien dedicó una parte importante de su obra Quod nihil (...) scitur a criticar a Aristóteles, aunque más aún a sus comentaristas.Palabras claveFilosofía del Renacimiento, Francisco Sánchez, Juan Luis Vives, Gianfrancesco Pico, aristotelismo, historia de la filosofía.AbstractIn the intellectual frame of the Renaissance, there were some thinkers who did not agree with the Aristotelism prevailing at the time. The variety of their philosophical positions and opinions may have been an obstacle for an approach to their similarities regarding the Aristotelian critic. The case of Juan Luis Vives and Gianfrancesco Pico della Mirandola can be paradigmatic. Also Francisco Sánchez, who strongly joined their position, devoted an important part of his play Quod nihil scitur to criticize Aristotle –although he focused on his commentators above all.KeywordsPhilosophy in the Renaissance, Francisco Sanchez, Juan Luis Vives, Gianfrancesco Pico, Aristotelism, History of Philosophy. (shrink)

El presente artículo intenta ofrecer un marco documental para la discusión sobre la estructura cosmológica de Ferecides de Siros. Partiendo de la polémica entre quienes le adjudican un cosmograma quinario y aquellos que lo interpretan septenario, proponemos un recorrido por las antiguas doctrinas cosmológicas quinarias, tanto griegas como orientales, a fin de explorar su recurrencia y variedad. Se constata que la disputa religiosa entre los apologetas del cinco y los del siete existía ya en la antigüedad, pudiendo haber afectado a (...) la lectura que los doxógrafos hicieron entonces de la obra de Ferecides. Se expone la teoría de Nick Allen sobre la existencia de una «ideología pentádica» indoeuropea y se critica su sesgo idealista (pitagórico en la línea de Dumézil). Finalmente, se suscribe la hipótesis del origen «protogeométrico» de muchos de estos mapas ontológicos quinarios y se recapitulan las posibles referencias que manejaba el maestro de Pitágoras cuando ideó su teogonía. (shrink)