We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria. The amount of energy that mitochondria make available for gene expression varies considerably. It depends on: the energetic demands of the tissue; the mitochondrial DNA (mtDNA) mutant load; the number of mitochondria; stressors present in the cell. Hence, when failing mitochondria place the cell in energy crisis there are major effects on gene expression affecting (...) the risk of degenerative diseases, cancer and ageing. In 2015 the UK parliament approved a change in the regulation of IVF techniques, allowing “Mitochondrial replacement therapy” to become a reproductive choice for women at risk of transmitting mitochondrial disease to their children. This is the first time that this technique will be available. Therefore understanding the interaction between mitochondria and the nucleus has never been more important. (shrink)

Often side-lined or simplified, evil women challenge societal norms of womanhood. This volume explores how evil women have been constructed, punished, and erased within literature, culture, and film and how this contributes to our understanding of womanhood.

In _Politics and Progress_, Muir aims to outline the political and social aims of liberalism and how it differs from conservatism and socialism as well as philosophising what a truly liberal society would look like. Originally published in 1923, this study details the political situation as it stood then, the past achievements of liberalism and what immediate problems society is facing that need to solved. This title will be of interest to students of politics.

This article focuses on Bretherton’s treatment of Pentecostalism and Black Power and how they conceive and challenge notions of democracy, citizenship and capitalism. Recognising the ‘tensional’ relationship between democracy and Christianity, I explore his treatment of Pentecostalism and capitalism. I am sympathetic to Bretherton’s analysis of the socio-political transformation Pentecostalism offers, but point to regressive influences associated with the ‘prosperity gospel’. Relating his treatment of Black Power to the wider ‘Black radical tradition’, I conclude with reference to political activism in (...) the UK. (shrink)

Eugene 'Gene' Vernier worked as a fashion photographer for British Vogue from 1954 to 1967, during one of the most exciting periods in fashion history. Shooting of-the-moment looks from the likes of Christian Dior and Emilio Pucci and top models including Celia Hammond, Jean Shrimpton, and current Vogue creative director Grace Coddington, Vernier worked with some of the biggest names in the industry. Yet he was relatively unconcerned with celebrity. Interested only in bringing out the very best in each frame, (...) Vernier was a true craftsman in the fashion photography trade. Featuring more than one hundred of Vernier's own favorite photographs drawn from Vogue's extensive photo archive, this lavishly illustrated volume reveals remarkable innovation in the use of props, backdrops, and location. Whether he was photographing his subjects by the sea, with a canine companion, or perfectly positioned atop a pale pink convertible, Vernier's careful composition enhanced the essence of his subject. Vernier shot mostly in black-and-white, and his trademark “look” is one of classic femininity. He sought to capture models when they were relaxed, enjoying the clothing, and confident that their photographer would show both only at their best. Providing commentary on the photographs are fashion history expert Becky Conekin and Vogue historian Robin Muir. This is first book to focus on Vernier's work at Vogue and it allows readers a rare glimpse of his inimitable blend of technical excellence and an eye for experimentation. (shrink)