In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide‐spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro‐ and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio‐ and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for (...) repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches. (shrink)

JOVO BAKIĆ, EVROPSKA KRAJNJA DESNICA 1945-2018, CLIO, BEOGRAD, 2019.Jovica Pavlović.

This paper considers the role of mathematics in the process of acquiring new knowledge in physics and astronomy. The defining of the notions of continuum and discreteness in mathematics and the natural sciences is examined. The basic forms of representing the heuristic function of mathematics at theoretical and empirical levels of knowledge are studied: deducing consequences from the axiomatic system of theory, the method of generating mathematical hypotheses, “pure” proofs for the existence of objects and processes, mathematical modelling, the formation (...) of mathematics on the basis of internal mathematical principles and the mathematical theory of experiment. (shrink)