"Humanitarian intervention" as used below means action by international actors across national boundaries including the use of military force taken with the objective of relieving severe and widespread human suffering and violation of human rights within states where local authorities are unwilling or unable to do so. This essay will attempt better to understand decisions about humanitarian intervention from the narrow perspective of looking at the proximate considerations attendant to the intervention itself, particularly focusing on the priority of ground_level implementation (...) and the recognition of the integral relationship between military action and reconstruction. Since what is confronted on the ground will be determinative, it is important to see if the decisions above can be better connected to the realities below. The inherent complexity of the subject will be confirmed here using selected cases with which the author has experience in the field; concepts and constructs identified which have been developed in attempts to frame the problem; constraints faced by the policy_makers indicated; and moral aspects of the enterprise considered. (shrink)

The cellular processes of transport, division and, possibly, early development all involve microtubule‐based motors. Recent work shows that, unexpectedly, many of these cellular functions are carried out by different types of kinesin and kinesin‐related motor proteins. The kinesin proteins are a large and rapidly growing family of microtubule‐motor proteins that share a 340‐amino‐acid motor domain. Phylogenetic analysis of the conserved motor domains groups the kinesin proteins into a number of subfamilies, the members of which exhibit a common molecular organization and (...) related functions. The kinesin proteins that belong to different subfamilies differ in their rates and polarity of movement along microtubules, and probably in the particles/organelles that they transport. The kinesins arose early in eukaryotic evolution and gene duplication has allowed functional specialization to occur, resulting in a surprisingly large number of different classes of these proteins adapted for intracellular transport of vesicles and organelles, and for assembly and force generation in the meiotic and mitotic spindles. (shrink)