For successful application of educational inclusive concept, next to the material and technical requirements, of high importance is also the quality and improvement of educational practice, education and competence of all participants in the educational process. Teachers are crucial part of the educational process so their acquired knowledge and skills are of great importance for the success of the inclusive education. Aim of this paper was to determine geography teacher’s attitudes towards working with pupils with developmental difficulties. For the purpose (...) of the research survey was conducted including geography teachers in elementary and secondary schools in Croatia. Research results indicate that teachers do not consider themselves educated enough neither competent for everyday work with pupils with developmental difficulties and they express the need for additional education. In their school work they try to adopt teaching materials and methods according to children’s difficulties. Cooperation with school professional and pedagogical service and parents is one of the main preconditions for successful teaching. There are significant differences in teacher’s attitudes in elementary in relation to ones in secondary schools. (shrink)

The study of cellular senescence and proliferative lifespan is becoming increasingly important because of the promises of autologous cell therapy, the need for model systems for tissue disease and the implication of senescent cell phenotypes in organismal disease states such as sarcopenia, diabetes and various cancers, among others. Here, we explain the concepts of proliferative cellular lifespan and cellular senescence, and we present factors that have been shown to mediate cellular lifespan positively or negatively. We review much recent literature and (...) present potential molecular mechanisms by which lifespan mediation occurs, drawing from the fields of telomere biology, metabolism, NAD+ and sirtuin biology, growth factor signaling and oxygen and antioxidants. We conclude that cellular lifespan and senescence are complex concepts that are governed by multiple independent and interdependent pathways, and that greater understanding of these pathways, their interactions and their convergence upon specific cellular phenotypes may lead to viable therapies for tissue regeneration and treatment of age‐related pathologies, which are caused by or exacerbated by senescent cells in vivo. (shrink)