BioPortal is a Web portal that provides access to a library of biomedical ontologies and terminologies developed in OWL, RDF(S), OBO format, Protégé frames, and Rich Release Format. BioPortal functionality, driven by a service-oriented architecture, includes the ability to browse, search and visualize ontologies (Figure 1). The Web interface also facilitates community-based participation in the evaluation and evolution of ontology content.

Ce texte a déjà paru sur Techno-science.net. Des chercheurs découvrent la formule mathématique du rythme et avancent que notre cerveau pourrait être câblé pour y répondre. Une nouvelle étude montre que tout compositeur, de Bach à Brubeck, répète des motifs rythmiques, de sorte que la partie reproduit le tout. Une équipe de recherche dirigée par les neuroscientifiques Daniel Levitin et Vinod Menon, respectivement des universités McGill et Stanford, a analysé les partitions de quelque 2 000 compositions - Mathématiques – Nouvel (...) article. (shrink)

We examined the course of caregiver motherese and the course of the infant’s response based on home movies from two single cases: a boy with typical development and a boy with autistic development. We first blindly assessed infant CG interaction using the Observer computer-based coding procedure, then analyzed speech CG production using a computerized algorithm. Finally we fused the two procedures and filtered for co-occurrence. In this exploratory study we found that the course of CG parentese differed based on gender (...) and child status. The course of an infant’s response to CG vocalization differed according to the type of speech and child status. Mothers spent more time interacting with infants, and fathers appeared to interact with their child preferentially between 12 and 18 months in the TD boy, but not in the AD boy. The TD boy responded equally well to motherese compared to other speech after 1 year of age. For the AD boy, the responses to both types of speech were lower than in the boy with TD and decreased from the second to the third semester. Keywords: Autism; motherese; early interaction; computational methods. (shrink)

Like most bilaterian animals, the annelid Platynereis dumerilii generates the majority of its body axis in an anterior to posterior temporal progression with new segments added sequentially. This process relies on a posterior subterminal proliferative body region, known as the "segment addition zone" (SAZ). We explored some of the molecular and cellular aspects of posterior elongation in Platynereis, in particular to test the hypothesis that the SAZ contains a specific set of stem cells dedicated to posterior elongation.We cloned and characterized (...) the developmental expression patterns of orthologs of 17 genes known to be involved in the formation, behavior, or maintenance of stem cells in other metazoan models. These genes encode RNA-binding proteins(e.g., tudor, musashi, pumilio) or transcription factors(e.g., myc, id, runx) widely conserved in eumetazoans. Most of these genes are expressed both in the migrating primordial germ cells and in overlapping ring-like patterns in the SAZ, similar to some previously analyzed genes(piwi, vasa). The SAZ patterns are coincident with the expression of proliferation markers cyclin B and PCNA. EdU pulse and chase experiments suggest that new segments are produced through many rounds of divisions from small populations of teloblast-like posterior stem cells. The shared molecular signature between primordial germ cells and posterior stem cells in Platynereis thus corresponds to an ancestral "stemness" program. (shrink)

For over fifty years, evaluators have used theories of change to articulate the causal logic underpinning how an intervention is intended to bring about a desired change. From its origins in program evaluation, the approach has been adopted more widely for purposes from programme design to programme management. As theories of change continue to be used for multiple purposes, it is an opportune moment for the evaluation community - where the approach originated - to provide their perspective on the strengths (...) and limitations of the approach and its future directions. To provide these perspectives, we asked nearly thirty of the world's leading evaluators and program theorists to provide a short essay on the past, present and future of theories of change. This book presents their insights organized into five main themes: the use of theories of change in broader public policy contexts; using theories of change to establish causality; developing theories of change reflective of multiple stakeholder perspectives; using theories of change to understand wider societal change processes; and applying theories of change approaches for multiple purposes. By sharing these diverse perspectives, the book aims to both provide evaluators and emerging programme theorists with critical perspectives to inform future practice. (shrink)