Digit ratio (2d:4d) as a Marker for mental disorders: Low (masculinized) 2d:4d in autism-spectrum disorders, high (feminized) 2d:4d in schizophrenic-spectrum disorders [Book Review]

Behavioral and Brain Sciences 31 (3):283-284 (2008)
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Abstract

Augmenting and supplementing the arguments of Crespi & Badcock (C&B), I show that digit ratio (2D:4D), a putative marker of prenatal androgen action, indeed appears differentially altered in autism-spectrum disorders (lower/masculinized) versus schizophrenic-spectrum disorders (higher/feminized). Consistent with C&B's framework, some evidence (substantial heritability, assortative mating, sex-specific familial transmission) points to possible sex chromosome and imprinted genes effects on 2D:4D expression

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10.1017/s0140525x08004445

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