Models for MHC‐restricted T‐cell antigen recognition

Bioessays 5 (4):153-157 (1986)
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Abstract

Current models for T‐cell recognition of foreign antigen depict the T‐cell receptor as having a single antibody‐like combining site which binds a complex of MHC and antigen. An alternative hypothesis is presented here; it is proposed that the first domains of the MHC function as inverted V‐like regions to complement the TcR V‐regions in creating antigen binding sites.

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10.1002/bies.950050404

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