Abstract |
Proponents of the emerging field of P4 medicine argue that computational integration and analysis of patient-specific “big data” will revolutionize our health care systems, in particular primary care-based disease prevention. While many ambitions remain visionary, steps to personalize medicine are already taken via personalized genomics, mobile health technologies and pilot projects. An important aim of P4 medicine is to enable disease prevention among healthy persons through detection of risk factors. In this paper, we examine the current status of P4 medicine in light of historical and current challenges to predictive and preventive medicine, including overdiagnosis and overtreatment. Moreover, we ask whether it is likely that in silico integration of patient-specific data will be able to better deal such challenges and to turn risk predictions into disease-preventive actions in a wider social context. Given the lack of evidence that P4 medicine can tip the balance between benefits and harms in preventive medicine, we raise concerns about the current promotion of P4 medicine as a solution to the current challenges in public health.
|
Keywords | No keywords specified (fix it) |
Categories | (categorize this paper) |
Options |
![]() ![]() ![]() ![]() |
Download options
References found in this work BETA
Big Data: A Revolution That Will Transform How We Live, Work, and Think.[author unknown] - 2013
What Difference Does Quantity Make? On the Epistemology of Big Data in Biology.S. Leonelli - 2014 - Big Data and Society 1 (1).
The New Holism: P4 Systems Medicine and the Medicalization of Health and Life Itself.Henrik Vogt, Bjørn Hofmann & Linn Getz - 2016 - Medicine, Health Care and Philosophy 19 (2):307-323.
Personalized Genomic Medicine and the Rhetoric of Empowerment.Eric T. Juengst, Michael A. Flatt & Richard A. Settersten - 2012 - Hastings Center Report 42 (5):34-40.
View all 14 references / Add more references
Citations of this work BETA
The Changing Landscape of the Philosophy of Medicine.Megan Delehanty - 2019 - Philosophy Compass 14 (8).
Similar books and articles
Personalizing Medicine: Disease Prevention in Silico and in Socio.Sara Green & Henrik Vogt - 2016 - Humana Mente 9 (30).
Molecular Medicine and Concepts of Disease: The Ethical Value of a Conceptual Analysis of Emerging Biomedical Technologies. [REVIEW]Marianne Boenink - 2010 - Medicine, Health Care and Philosophy 13 (1):11-23.
The Naturalness of the Artificial and Our Concepts of Health, Disease and Medicine. Y. Barilan & Moshe Weintraub - 2004 - Medicine, Health Care and Philosophy 4 (3):311-325.
The Ethics of Basing Community Prevention in General Practice.M. Weingarten & A. Matalon - 2010 - Journal of Medical Ethics 36 (3):138-141.
Personalized Medicine: Evidence of Normativity in its Quantitative Definition of Health.Henrik Vogt, Bjørn Hofmann & Linn Getz - 2016 - Theoretical Medicine and Bioethics 37 (5):401-416.
In Silico Medicine: The Practitioners’ Points of View Medicine: The Practitioners’ Points of View Medicine.Matteo Cerri, Markus Reiterer & Marco Viceconti - 2016 - Humana Mente 9 (30).
Why is Preventive Medicine Exempted From Ethical Constraints?P. Skrabanek - 1990 - Journal of Medical Ethics 16 (4):187-190.
Tensions and Opportunities in Convergence: Shifting Concepts of Disease in Emerging Molecular Medicine. [REVIEW]Marianne Boenink - 2009 - NanoEthics 3 (3):243-255.
A Return to Biological Thinking in Medicine.Henrik R. Wulff - 2001 - Medicine, Health Care and Philosophy 4 (1):1-3.
The Evolution of Western Medicine.Henrik Wulff & Morten Skydsgaard - 1998 - Medicine, Health Care and Philosophy 1 (1):79-81.
Transplant Medicine as Borderline Medicine.Volker H. Schmidt - 2003 - Medicine, Health Care and Philosophy 6 (3):319-321.
Preventive Vs. Curative Medicine: Perspectives of the Jewish Legal Tradition.Martin P. Golding - 1983 - Journal of Medicine and Philosophy 8 (3):269-286.
Commentary on Wim Dekkers’s and Marcel Olde Rikkert's: “What is a Genetic Disease? The Example of Alzheimer’s Disease” and Stephen Tyreman's: “Causes of Illness in Clinical Practice: A Conceptual Exploration”. [REVIEW]Lennart Nordenfelt - 2006 - Medicine, Health Care and Philosophy 9 (3):317-319.
Disease From a Historical and Social Point of View: Some Remarks Based on the Needs of Preventive Medicine.Øivind Larsen - 1984 - In Lennart Nordenfelt & B. I. B. Lindahl (eds.), Health, Disease, and Causal Explanations in Medicine. Reidel. pp. 153--164.
Analytics
Added to PP index
2018-07-18
Total views
20 ( #557,392 of 2,504,809 )
Recent downloads (6 months)
4 ( #170,306 of 2,504,809 )
2018-07-18
Total views
20 ( #557,392 of 2,504,809 )
Recent downloads (6 months)
4 ( #170,306 of 2,504,809 )
How can I increase my downloads?
Downloads