Social scientists would do well to steer clear of polygenic scores

Behavioral and Brain Sciences 46:e212 (2023)
  Copy   BIBTEX

Abstract

The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.

Categories

Keywords

Reprint years

DOI

10.1017/s0140525x22002448

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 92,038

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

My notes

Similar books and articles

Often wrong, sometimes useful: Including polygenic scores in social science research.Jason Fletcher - 2023 - Behavioral and Brain Sciences 46:e213.
Polygenic scores and social science.Walter Veit & Heather Browning - 2023 - Behavioral and Brain Sciences 46:e229.
Tractable limitations of current polygenic scores do not excuse genetically confounded social science.Damien Morris, Stuart J. Ritchie & Alexander I. Young - 2023 - Behavioral and Brain Sciences 46:e222.
Polygenic scores for social science: Clarification, consensus, and controversy.Callie H. Burt - 2023 - Behavioral and Brain Sciences 46:e232.
Bioethicists Are Not so Divided on Reproductive Testing for Non-Medical Traits: Emerging Perspectives on Polygenic Scores.Kalina Kamenova & Hazar Haidar - 2023 - American Journal of Bioethics 23 (3):48-50.
Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk.A. C. Palk, S. Dalvie, J. de Vries, A. R. Martin & D. J. Stein - 2019 - Philosophy, Ethics, and Humanities in Medicine 14 (1):1-12.
Three models for the regulation of polygenic scores in reproduction.Sarah Munday & Julian Savulescu - 2021 - Journal of Medical Ethics 47 (12):e91-e91.
Polygenic risk scores cannot make their mark on psychiatry without considering epigenetics.Diane C. Gooding & Anthony P. Auger - 2023 - Behavioral and Brain Sciences 46:e216.
Polygenic scores ignore development and epigenetics, dramatically reducing their value.David S. Moore - 2023 - Behavioral and Brain Sciences 46:e220.
GWASs and polygenic scores inherit all the old problems of heritability estimates.Sahotra Sarkar - 2023 - Behavioral and Brain Sciences 46:e227.
Polygenic scores, and the genome-wide association studies they derive from, will have difficulty identifying genes that predispose one to develop a social behavioral trait.Edward Fox - 2023 - Behavioral and Brain Sciences 46:e214.
Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology.Callie H. Burt - 2023 - Behavioral and Brain Sciences 46:e207.
Nurtured Genetics: Prenatal Testing and the Anchoring of Genetic Expectancies.Rémy Furrer, Shai Carmi, Todd Lencz & Gabriel Lázaro-Muñoz - 2023 - American Journal of Bioethics 23 (3):42-44.
Increasing the use of functional and multimodal genetic data in social science research.Benjamin C. Nephew, Chris Murgatroyd, Justin J. Polcari, Hudson P. Santos & Angela C. Incollingo Rodriguez - 2023 - Behavioral and Brain Sciences 46:e223.
Polygene Risk Scores.James Woodward & Kenneth Kendler - 2023 - Philosophy of Medicine 4 (1).

Analytics

Added to PP
2023-09-12

Downloads
3 (#1,712,963)

6 months
1 (#1,473,216)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references