Abstract
In 1628, Harvey published his blood circulation theory, which triggered questionings by Riolan and Descartes at several levels: metaphysical, physiological, anatomical, institutional. The blood controversy tackles various conceptions of life that refer to various metaphysical backgrounds (Aristotelician, Cartesian or Neoplatonic), several kinds of relationships between natural philosophy and theology (compatibility, strict distinction, a balance between the two), distinct representations of the human body (dynamic, mechanic, aesthetic). It illustrates a point in time when medicine reforms and reorganizes its epistemic style and its rationality in order to explain the complexity of the body’s fabric.