This paper introduces a new Ehrenfeucht-Fraïssé type game that is played on two classes of models rather than just two models. This game extends and generalizes the known Ajtai-Fagin game to the case when there are several alternating moves played in different models. The game allows Duplicator to delay her choices of the models till the very end of the game, making it easier for her to win. This adds on the toolkit of winning strategies for Duplicator in Ehrenfeucht-Fraïssé type (...) games and opens up new methods for tackling some open problems in descriptive complexity theory. As an application of the class game, it is shown that, if m is a power of a prime, then first order logic augmented with function quantifiers F1n of arity 1 and height n < m can not express that the size of the model is divisible by m. This, together with some new expressibility results for Henkin quantifiers H1n gives some new separation results on the class of finite models among various F1n on one hand and between F1n and H1n on the other. Since function quantifiers involve a bounded type of second order existential quantifiers, the class game solves an open problem raised by Fagin, which asks for some inexpressibility result using a winning strategy by Duplicator in a game that involves more than one coloring round. (shrink)

In [9] we introduced a new framework for asymptotic probabilities, in which a $\sigma-additive$ measure is defined on the sample space of all sequences $A = $ of finite models, where the universe of An is {1, 2, .., n}. In this framework we investigated the strong 0-1 law for sentences, which states that each sentence either holds in An eventually almost surely or fails in An eventually almost surely. In this paper we define the strong convergence law for formulas, (...) which carries over the ideas of the strong 0-1 law to formulas with free variables, and roughly states that for each formula φ(x), the fraction of tuples a in An, which satisfy the formula φ(x), almost surely has a limit as n tends to infinity. We show that the infinitary logic with finitely many variables has the strong convergence law for formulas for the uniform measure, and further characterize the measures on random graphs for which the strong convergence law holds. (shrink)

We introduce a new framework for asymptotic probabilities of sentences, in which we have a σ-additive measure on the sample space of all sequences A = {A n } of finite models, where the universe of A n is {1,2... n}, and use this framework to strengthen 0-1 laws for logics.

We introduce a new framework for asymptotic probabilities of sentences, in which we have a σ-additive measure on the sample space of all sequencesA= {} of finite models, where the universe ofis {1,2, …, n}. and use this framework to strengthen 0-1 laws for logics.

We prove a local normal form theorem of the Gaifman type for the infinitary logic L∞ωω whose formulas involve arbitrary unary quantifiers but finite quantifier rank. We use a local Ehrenfeucht-Fraïssé type game similar to the one in [9]. A consequence is that every sentence of L∞ωω of quantifier rank n is equivalent to an infinite Boolean combination of sentences of the form ψ, where ψ has counting quantifiers restricted to the -neighborhood of y.

For each truth-functionally complete set of connectives, we construct a sound and complete natural deduction system containing no axioms and the smallest possible number of inference rules, namely one.

We give an axiomatization of first‐order logic enriched with the almost‐everywhere quantifier over finitely additive measures. Using an adapted version of the consistency property adequate for dealing with this generalized quantifier, we show that such a logic is both strongly complete and enjoys Craig interpolation, relying on a (countable) model existence theorem. We also discuss possible extensions of these results to the almost‐everywhere quantifier over countably additive measures.

This paper studies the expressive power that an extra first order quantifier adds to a fragment of monadic second order logic, extending the toolkit of Janin and Marcinkowski [JM01].We introduce an operation existsn on properties S that says "there are n components having S". We use this operation to show that under natural strictness conditions, adding a first order quantifier word u to the beginning of a prefix class V increases the expressive power monotonically in u. As a corollary, if (...) the first order quantifiers are not already absorbed in V, then both the quantifier alternation hierarchy and the existential quantifier hierarchy in the positive first order closure of V are strict.We generalize and simplify methods from Marcinkowski [Mar99] to uncover limitations of the expressive power of an additional first order quantifier, and show that for a wide class of properties S, S cannot belong to the positive first order closure of a monadic prefix class W unless it already belongs to W.We introduce another operation alt on properties which has the same relationship with the Circuit Value Problem as reach has with the Directed Reachability Problem. We use alt to show that Πn⊈ FO, Σn⊈ FO, and Δn+1⊈ FOB, solving some open problems raised in [Mat98]. (shrink)

We prove a local normal form theorem of the Gaifman type for the infinitary logic L∞ωω whose formulas involve arbitrary unary quantifiers but finite quantifier rank. We use a local Ehrenfeucht-Fraïssé type game similar to the one in [9]. A consequence is that every sentence of L∞ωω of quantifier rank n is equivalent to an infinite Boolean combination of sentences of the form ψ, where ψ has counting quantifiers restricted to the -neighborhood of y.

We obtain an almost everywhere quantifier elimination for (the noncritical fragment of) the logic with probability quantifiers, introduced by the first author in [10]. This logic has quantifiers like $\exists ^{ \ge 3/4} y$ which says that "for at least 3/4 of all y". These results improve upon the 0-1 law for a fragment of this logic obtained by Knyazev [11]. Our improvements are: 1. We deal with the quantifier $\exists ^{ \ge r} y$ , where y is a tuple (...) of variables. 2. We remove the closedness restriction, which requires that the variables in y occur in all atomic subformulas of the quantifier scope. 3. Instead of the unbiased measure where each model with universe n has the same probability, we work with any measure generated by independent atomic probabilities pR for each predicate symbol R. 4. We extend the results to parametric classes of finite models (for example, the classes of bipartite graphs, undirected graphs, and oriented graphs). 5. We extend the results to a natural (noncritical) fragment of the infinitary logic with probability quantifiers. 6. We allow each pR , as well as each r in the probability quantifier $(\exists ^{ \ge r} y)$ , to depend on the size of the universe. (shrink)

Gaifman's normal form theorem showed that every first-order sentence of quantifier rank n is equivalent to a Boolean combination of “scattered local sentences”, where the local neighborhoods have radius at most 7n−1. This bound was improved by Lifsches and Shelah to 3×4n−1. We use Ehrenfeucht–Fraïssé type games with a “shrinking horizon” to get a spectrum of normal form theorems of the Gaifman type, depending on the rate of shrinking. This spectrum includes the result of Lifsches and Shelah, with a more (...) easily understood proof and with the bound on the radius improved to 4n−1. We also obtain bounds for a normal form theorem of Schwentick and Barthelmann. (shrink)

Human neoplasms develop following the progressive accumulation of genetic and epigenetic alterations to oncogenes and tumor suppressor genes. These alterations confer a growth advantage to the cancer cell, leading to its clonal proliferation, invasion into surrounding tissues, and spread to distant organs. Genes that are altered in neoplasia affect three major biologic pathways that normally regulate cell growth and tissue homeostasis: the cell cycle, apoptosis, and differentiation. While each of these pathways can be defined by a unique set of molecular (...) events, they are not biologically separate. Rather, they function more as an integrated molecular network, and perturbations in one pathway can have profound consequences on another. Insights into what distinguishes the regulation of growth and differentiation in a normal cell versus a cancer cell have led to the development of novel anticancer therapies. BioEssays 24:83–90, 2002. © 2002 John Wiley & Sons, Inc. (shrink)