Although Kant’s legacy for the subsequent continental tradition is widely acknowledged, studies dedicated to this complex and multifaceted relation are not as widespread. Kant and the Continental T...

Unity is a central concept in the Critique of Pure Reason, since it is only through the unifying act of our spontaneous faculties that an experience can emerge, according to Kant. However, the faculty of reason brings forth a different unity than that of the understanding: Kant characterizes the former as a collective unity, while the latter as a distributive unity. This article aims to explain the meaning of these terms, with reference to the Nachlass on metaphysics and the writings (...) on right where Kant employs them in a clearer manner. This explanation can provide a basis to understand the difference between the faculty of understanding and the faculty of reason within the first Critique, a difference rather neglected by scholars, who have focused mainly on Kant’s distinction between sensibility and understanding. (shrink)

The correct execution of the DNA replication process is crucially import for the maintenance of genome integrity of the cell. Several types of sources, both endogenous and exogenous, can give rise to DNA damage leading to the DNA replication fork arrest. The processes by which replication blockage is sensed by checkpoint sensors and how the pathway leading to resolution of stalled forks is activated are still not completely understood. However, recent emerging evidence suggests that one candidate for a sensor of (...) replication stress is ATR and that, together with a member of RecQ family helicases, Werner syndrome protein (WRN) and MRE11 complex, can collaborate to promote the restarting of DNA synthesis through the resolution of stalled replication forks. Here, we discuss how WRN, the MRE11 complex and the ATR kinase could work together in response to replication blockage to avoid DNA replication fork collapse and genome instability. BioEssays 26:306–313, 2004. © 2004 Wiley Periodicals, Inc. (shrink)