Sui Han geht von der Mehrdeutigkeit des Begriffs des Nichtseienden – die der von Aristoteles in einer berühmten Formulierung festgestellten Mehrdeutigkeit des Seienden teilweise, aber nicht völlig analog ist – und der „Aussageverflechtung von Sein und Nichtsein“ aus. Sie legt dar, dass bei Plotin mit Blick auf sämtliche Seinsebenen vom Einen-Guten bis hinab zur Materie in jeweils unterschiedlichem Sinn sowohl von deren Sein als auch von deren Nichtsein gesprochen werden kann. Diesem unterschiedlichen Sinn jeweils auf die Spur zu kommen, ist (...) das eigentliche Anliegen der Autorin. (shrink)

In diesem Buch wird eine Strategie gegen zwei skeptische Tendenzen entwickelt, deren eine den Sonderstatus von Personen bestreitet und deren andere" wahr"für ein Prädikat ausgibt, das schlicht gewissen Verwendungsregeln unterworfen und instrumentalistisch zu interpretieren sei. Die antiskeptische Strategie soll dadurch zum Erfolg führen, dass die beiden von der Skepsis bedrohten Sachverhalte sich gegenseitig stützen. Gezeigt wird, dass die Aufgabe des Sonderstatus von Personen die Leugnung der Bedeutung von" wahr"impliziert und umgekehrt. Positiv gewendet: Die Bedeutung von" wahr"ist in Beziehung auf Subjektivität (...) zu explizieren, und Subjektivität erschließt sich theoretisch durch die Beziehung auf Wahrheit. Die Vorgehensweise ist im wesentlichen negativ; ihr positiver Aspekt besteht in der systematischen Zuordnung der negativen Ergebnisse. Zu Gegenständen der Kritik werden dabei der Naturalismus in der reduktiven wie der eliminationistischen Variante sowie ontologisierende Ansätze, d. h. Versuche, philosophische Probleme durch das Postulat von Entitäten sui generis zu lösen. In der Ablehnung von Ontologisierungen und im negativen Charakter der philosophischen Tätigkeit ergeben sich Berührungspunkte mit dem späten Wittgenstein. Die Differenz liegt in der erwähnten Zuordnung der Resultate der Kritik, die es erlaubt, die intendierte Position als eine transzendentalphilosophische zu charakterisieren. (shrink)

Lorsque Socrate dit : " Connais-toi toi-même ", il veut que je me connaisse, non pas métaphysiquement, non pas dans mon essence, non pas dans ce qui est insaisissable, mais dans ce qui est saisissable ; il veut que je sache ce que je suis, ce que je veux et ce que je peux. La connaissance individualiste de moi-même comprend la double critique de ma volonté et de ma puissance.

If identity is to be taken as a relation, not between any object and itself, nor between expressions , but between "intensions" or Fregean "Sinnen" of individual constants , then not only definite descriptions but also grammatically proper names ought to have intensions. This, however, has been repudiated by J. St. Mill and, more recently and more persuasively, by Saul Kripke. So an attempt will be made to interpret proper names as definite descriptions sui generis, namely, "rigid" descriptions referring to (...) the way the bearer of the name is called, in certain contexts, in the real world. To avoid circularity or a vicious regressus in infinitum, however, one has to do this on the basis of a distinction between "names" and "name-radicals". (shrink)

Nähere Informationen zu diesem Buch erhalten Sie direkt vom Verlag / For further information about this title please contact Mohr Siebeck.

Felix Kaufmanns Wissenschaftstheorie Hans-Georg Zilian. X KAUFMANN, DIE ÖKONOMEN UND DAS A PRIORI Bei den österreichischen Grenznutzentheoretikern, mit deren Arbeiten sich Kaufmann vor allem auseinandersetzte, ist von ...

The Neo‐Darwinian concept of natural selection is plausible when one assumes a straightforward causation of phenotype by genotype. However, such simple 1:1 mapping must now give place to the modern concepts of gene regulatory networks and gene expression noise. Both can, in the absence of genetic mutations, jointly generate a diversity of inheritable randomly occupied phenotypic states that could also serve as a substrate for natural selection. This form of epigenetic dynamics challenges Neo‐Darwinism. It needs to incorporate the non‐linear, stochastic (...) dynamics of gene networks. A first step is to consider the mathematical correspondence between gene regulatory networks and Waddington's metaphoric ‘epigenetic landscape’, which actually represents the quasi‐potential function of global network dynamics. It explains the coexistence of multiple stable phenotypes within one genotype. The landscape's topography with its attractors is shaped by evolution through mutational re‐wiring of regulatory interactions – offering a link between genetic mutation and sudden, broad evolutionary changes. (shrink)

The stunning possibility of “reprogramming” differentiated somatic cells to express a pluripotent stem cell phenotype (iPS, induced pluripotent stem cell) and the “ground state” character of pluripotency reveal fundamental features of cell fate regulation that lie beyond existing paradigms. The rarity of reprogramming events appears to contradict the robustness with which the unfathomably complex phenotype of stem cells can reliably be generated. This apparent paradox, however, is naturally explained by the rugged “epigenetic landscape” with valleys representing “preprogrammed” attractor states that (...) emerge from the dynamical constraints of the gene regulatory network. This article provides a pedagogical primer to the fundamental principles of gene regulatory networks as integrated dynamic systems and reviews recent insights in gene expression noise and fate determination, thereby offering a formal framework that may help us to understand why cell fate reprogramming events are inherently rare and yet so robust. (shrink)

Justice, equality, and righteousness—these are some of our greatest moral convictions. Yet in times of social conflict, morals can become rigid, making religious war, ethnic cleansing, and political purges possible. Morality, therefore, can be viewed as pathology-a rhetorical, psychological, and social tool that is used and abused as a weapon. An expert on Eastern philosophies and social systems theory, Hans-Georg Moeller questions the perceived goodness of morality and those who claim morality is inherently positive. Critiquing the ethical "fanaticism" of Western (...) moralists, such as Immanuel Kant, Lawrence Kohlberg, John Rawls, and the utilitarians, Moeller points to the absurd fundamentalisms and impracticable prescriptions arising from definitions of good. Instead he advances a theory of "moral foolishness," or moral asceticism, extracted from the "amoral" philosophers of East Asia and such thinkers as Ludwig Wittgenstein and Niklas Luhmann. The moral fool doesn't understand why ethics are necessarily good, and he isn't convinced that the moral perspective is always positive. In this way he is like most people, and Moeller defends this foolishness against ethical pathologies that support the death penalty, just wars, and even Jerry Springer's crude moral theater. Comparing and contrasting the religious philosophies of Christianity, Daoism, and Zen Buddhism, Moeller presents a persuasive argument in favor of amorality. (shrink)

Introduces contemporary American philosophy of technology through six of its leading figures. The six American philosophers of technology whose work is profiled in this clear and concise introduction to the field—Albert Borgmann, Hubert Dreyfus, Andrew Feenberg, Donna Haraway, Don Ihde, and Langdon Winner—represent a new, empirical direction in the philosophical study of technology that has developed mainly in North America. In place of the grand philosophical schemes of the classical generation of European philosophers of technology, the contemporary American generation addresses (...) concrete technological practices and the co-evolution of technology and society in modern culture. Six Dutch philosophers associated with Twente University survey and critique the full scope and development of their American colleagues’ work, often illustrating shifts from earlier to more recent interests. Individual chapters focus on Borgmann’s engagement with technology and everyday life; Dreyfus’s work on the limits of artificial intelligence; Feenberg’s perspectives on the cultural and social possibilities opened by technologies; Haraway’s conception of the cyborg and its attendant blurring of boundaries; Ihde’s explorations of the place of technology in the lifeworld; and Winner’s fascination with the moral and political implications of modern technologies. American Philosophy of Technology offers an insightful and readable introduction to this new and distinctly American philosophical turn. Contributors are Hans Achterhuis, Philip Brey, René Munnik, Martijntje Smits, Pieter Tijmes, and Peter-Paul Verbeek. (shrink)

Written in the 1960s, TRUTH AND METHOD is Gadamer's magnum opus. Looking behind the self-consciousness of science, he discusses the tense relationship between truth and methodology. In examining the different experiences of truth, he aims to "present the hermeneutic phenomenon in its fullest extent.

The fateful combination of (i) the Dunning‐Kruger effect (ignorance of one's own ignorance) with (ii) the nonlinear dynamics of the echo‐chamber between reviewers and editors fuels a self‐reinforcing collective delusion system that sometimes spirals uncontrollably away from objectivity and truth. Escape from this subconscious meta‐ignorance is a formidable challenge but if achieved will help correct a central deficit of the peer‐review process that stifles innovation and paradigm shifts.

In this book Han Thomas Adriaenssen offers the first comparative exploration of the sceptical reception of representationalism in medieval and early modern philosophy. Descartes is traditionally credited with inaugurating a new kind of scepticism by saying that the direct objects of perception are images in the mind, not external objects, but Adriaenssen shows that as early as the thirteenth century, critics had already found similar problems in Aquinas's theory of representation. He charts the attempts of philosophers in both periods to (...) grapple with these problems, and shows how in order to address the challenges of scepticism and representation, modern philosophers in the wake of Descartes often breathed new life into old ideas, remoulding them in ways that we are just beginning to understand. His book will be valuable for historians interested in the medieval background to early modern thought, and to medievalists looking at continuity with the early modern period. -/- . (shrink)

The work of Thomas White represents a systematic attempt to combine the best of the new science of the seventeenth century with the best of Aristotelian tradition. This attempt earned him the criticism of Hobbes and the praise of Leibniz, but today, most of his attempts to navigate between traditions remain to be explored in detail. This paper does so for his ontology of accidents. It argues that his criticism of accidents in the category of location as entities over and (...) above substances was likely aimed at Francisco Suárez, and shows how White’s worries about the analysis of location were linked with his broader cosmological views. White rejects real qualities, but holds that the quantity of a substance is somehow distinct from its bearer. This reveals a common ground with some of his scholastic interlocutors, but lays bare a deep disagreement with thinkers like Descartes on the nature of matter. (shrink)

In this paper, findings from research in neuroscience of morality will be reviewed to consider the purposes of moral education. Particularly, I will focus on two main themes in neuroscience, novel neuroimaging and experimental investigations, and Bayesian learning mechanism. First, I will examine how neuroimaging and experimental studies contributed to our understanding of psychological mechanisms associated with moral functioning while addressing methodological concerns. Second, Bayesian learning mechanism will be introduced to acquire insights about how moral learning occurs in human brains. (...) Based on the reviewed neuroscientific research on morality, I will examine how evidence can support the model of moral education proposed by virtue ethics, Neo-Aristotelian moral philosophy in particular. Particularly, two main aims of virtue ethics-based moral education, the habituation of virtues and the cultivation of phronesis, will be discussed as the important purposes of moral education based on neuroscientific evidence. (shrink)

Loneliness in medicine is a serious problem not just for patients, for whom illness is intrinsically isolating, but also for physicians in the contemporary condition of medicine. We explore this problem by investigating the ideal physician-patient relationship, whose analogy with friendship has held enduring normative appeal. Drawing from Talbot Brewer and Nir Ben-Moshe, we argue that this appeal lies in a dynamic form of companionship incompatible with static models of friendship-like physician-patient relationships: a mutual refinement of embodied virtue that draws (...) both persons together. The ideal physician-patient relationship has a dialectical character that fosters each member's improvement of phenomenologically recognizing and embodying moral virtues. A key component of this dynamic is a commitment to the common goal of the patient's health, realized through joint interactivities and conversations over time. The physician's presence to the patient's suffering—understood best as an alienating phenomenological condition for the patient—orients and discloses possibilities for virtuous caregiving by structuring the meanings of the goals, conversations, and joint narrative constitutive of their relationship. Presence to suffering, paradoxically, is perhaps an important prerequisite for this dynamic partnership. These activities dialectically build an interpretive horizon of understanding through which moral goods and character refinement—in and for the other—may become revealed for both persons in their shared being-in-the-world. This analysis of suffering, mood, and revealing of (possible) moral goods has implications for addressing the modern problem of loneliness for patients and physicians, who are increasingly inhibited from building flourishing relationships with each other. (shrink)

In the tradition of Western medicine that goes back to Hippocrates, we teach medical students to see beyond the disease and to consider the patient as a whole—to take into account the broader context of family, lifestyle, and environmental exposures. For instance, when measuring blood pressure to diagnose hypertension, family history and situational stress must be considered. Moreover, repeated measurements at multiple time points must be performed to avoid a false-positive diagnosis due to temporary fluctuations of blood pressure. The diagnosis (...) then provides, in adherence to standard-of-care guidelines, the indication for antihypertensive therapy. The recommendations have been... (shrink)

[Without a theorising], a man might as well go into a gravel-pit and count the pebbles and describe the colours. How odd it is that anyone should not see that all observation must be for or against some view if it is to be of any service!Recent years have seen a steady shift of funding programs in biomedical research towards data collection, analysis, and management and its computational analysis. A sizable majority of new major funding opportunity announcements call for assembling (...) large sample banks and databases of molecular profiles of diseases or for computational tools for analysis, display, and distribution of the data. Large consortium projects, such as the Cancer Genome Atlas, the UK Biobank (Allen... (shrink)

The project was partially supported by a NSF grant of China. The author was grateful to Professor S. Lempp for his encouragement and suggestion while the author was visiting the Department of Mathematics at the University of Wisconsin.

It will be proved that the Shoenfield cupping conjecture holds in R/M, the quotient of the recursively enumerable degrees modulo the cappable r.e. degrees. Namely, for any [a], [b] ∈ R/M such that [0] $\prec$ [b] $\prec$ [a] there exists [c] ∈ R/M such that [c] $\prec$ [a] and [a] = [b] ∨ [c].

Machines will attain human levels of intelligence by the year 2040, predicts robotics expert Hans Moravec. And by 2050, they will have far surpassed us. In this mind-bending new book, Hans Moravec takes the reader on a roller coaster ride packed with such startling predictions. He tells us, for instance, that in the not-too-distant future, an army of robots will displace workers, causing massive, unprecedented unemployment. But then, says Moravec, a period of very comfortable existence will follow, as humans benefit (...) from a fully automated economy. And eventually, as machines evolve far beyond humanity, robots will supplant us. But if Moravec predicts the end of the domination by human beings, his is not a bleak vision. Far from railing against a future in which machines rule the world, Moravec embraces it, taking the startling view that intelligent robots will actually be our evolutionary heirs. "Intelligent machines, which will grow from us, learn our skills, and share our goals and values, can be viewed as children of our minds." And since they are our children, we will want them to outdistance us. In fact, in a bid for immortality, many of our descendants will choose to transform into "ex humans," as they upload themselves into advanced computers. We will become our children and live forever. In his provocative new book, the highly anticipated follow-up to his bestselling volume Mind Children, Moravec charts the trajectory of robotics in breathtaking detail. A must read for artificial intelligence, technology, and computer enthusiasts, Moravec's freewheeling but informed speculations present a future far different than we ever dared imagine. (shrink)