Personalized, Precision, and N-of-One Medicine: A Clarification of Terminology and Concepts

Perspectives in Biology and Medicine 62 (4):617-639 (2019)
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Abstract

In the tradition of Western medicine that goes back to Hippocrates, we teach medical students to see beyond the disease and to consider the patient as a whole—to take into account the broader context of family, lifestyle, and environmental exposures. For instance, when measuring blood pressure to diagnose hypertension, family history and situational stress must be considered. Moreover, repeated measurements at multiple time points must be performed to avoid a false-positive diagnosis due to temporary fluctuations of blood pressure. The diagnosis then provides, in adherence to standard-of-care guidelines, the indication for antihypertensive therapy. The recommendations have been...

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Sui Huang
Institute For Systems Biology Seattle

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