In this study, we explored how high school students’ participation in a local history research project about a historically Black cemetery in the Southeast United States contributed to their demonstration of historical empathy. Major findings show that students displayed historical empathy in research activities that occur beyond the traditional classroom through their examination of perspectives concerning representations of race and diversity in the social studies curriculum, the historical contexts about the impact of enslavement and Jim Crow segregation in their community, (...) and affective connections they made to their identities as citizens. We recommend that future studies focus on how social studies teachers, community organizations, and other educational providers can collaborate to promote historical empathy in and outside of schools with equity frameworks and curricular initiatives such as the National Council for the Social Studies College, Career, and Civic Life (C3) Framework. (shrink)

An English translation of Pierre Bayle's posthumous last book, Entretiens de Maxime et de Themiste (1707), in which Bayle defends his skeptical position on the problem of the evil. This book is often cited and attacked by G.W. Leibniz in his Theodicy (1710). Over one hundred pages of original philosophical and historical material introduce the translation, providing it with context and establishing the work's importance.

The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in all organisms analysed to date. In human cells, representatives of this family include the proteins defective in the cancer predisposition disorder Bloom's syndrome and the premature ageing condition, Werner's syndrome. Several pieces of evidence suggest that RecQ family helicases form associations with one or more of the cellular topoisomerases, and together these heteromeric complexes manipulate DNA structure to effect efficient DNA replication, (...) genetic recombination, or both. Here, we propose that RecQ helicases are required for ensuring that structural abnormalities arising during replication, such as at sites where replication forks encounter DNA lesions, are corrected with high fidelity. In mutants defective in these proteins, not only is replication abnormal, but cells display aberrant responses to DNA-damaging agents or inhibitors of DNA synthesis. We suggest that RecQ helicases may be important for the integration of cellular responses to these insults, such as by linking cell cycle checkpoint responses to recombinational repair. BioEssays 21:286–294, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

In 2007 th eAustralian government declared that remote Aboriginal communities were in crisis and launched the Northern Territory Intervention.

The DNA of all species is constantly under threat from both endogenous and exogenous factors, which damage its chemical structure. Probably the most common lesion that arises in cellular DNA is the loss of a base to generate an abasic site, which is usually referred to as an apurinic or apyrimidinic (AP) site. Since these lesions are potentially both cytotoxic and mutagenic, cells of all organisms express dedicated repair enzymes, termed AP endonucleases, to counteract their damaging effects. Indeed, many organisms (...) consider it necessary to express two or more of these lesion‐specific endonucleases, underscoring the requirement that exists to remove AP sites for the maintenance of genome integrity and cell viability. Most AP endonucleases are very versatile enzymes, capable of performing numerous additional repair roles. In this article, we review the AP endonuclease class of repair enzymes, with emphasis on the evolutionary conservation of structural features, not only between prokaryotic and eukaryotic homologues, but also between these enzymes and the RNase H domain of one class of reverse transcriptase. (shrink)

Animal data suggest that jet fuels such as JP-8 are associated with hearing deficits when combined with noise and that the effect is more pronounced than with noise exposure alone. Some studies suggest peripheral dysfunction while others suggest central auditory dysfunction. Human data are limited in this regard. The aim of this study was to investigate the possible chronic adverse effects of JP-8 combined with noise exposure on the peripheral and central auditory systems in humans. Fifty-seven participants who were current (...) personnel from the Royal Australian Air Force were selected. Based on their levels of exposure to jet fuels, participants were divided into three exposure groups. Groups were also categorised based on their noise exposure levels. All participants were evaluated by tympanometry, pure-tone audiometry, distortion product otoacoustic emissions, auditory brainstem response, words-in-noise, compressed speech, dichotic digit test, pitch pattern sequence test, duration pattern sequence test and adaptive test of temporal resolution. All auditory tests were carried out after the participants were away from the Air Force base for a minimum of two weeks, thus two weeks without jet fuel and noise exposure. Jet fuel exposure was significantly associated with hearing thresholds at 4 and 8 kHz; average hearing thresholds across frequencies in the better ear; DPOAEs at 2.8, 4 and 6 kHz; ABR wave V latency in the right ear; compressed speech and words-in-noise. Further analyses revealed that participants with low exposure level to jet fuels showed significantly better results for the aforementioned procedures than participants with moderate and high exposure levels. All results were controlled for the covariates of age and noise exposure levels. The results suggest that jet fuel exposure, when combined with noise exposure, has an adverse effect on audibility in humans. Taking all the test results into consideration, jet fuel exposure combined with noise exposure specifically seems to affect the peripheral hearing system in humans. (shrink)

Theodicy and Toleration Seem at first glance to be an unlikely pair of topics to treat in a single paper. Toleration usually means putting up with beliefs or actions with which one disagrees, and it is practiced because the beliefs or actions in question are not disagreeable enough to justify interference. It is usually taken to be a topic for moral and political philosophy. Theodicy, on the other hand, is the attempt to solve the problem of evil; that is, to (...) explain the origin of suffering and sin in a way that does not make God a moral cause of those evils.1 While theodicy concerns the notions of good and evil, and could therefore be considered a moral topic, historical and contemporary discussions of it have .. (shrink)

While evil has always fascinated philosophers, it is only in modern times that the existence of evil has been seen as a serious challenge to belief in the existence of a powerful and benevolent God. In order to demonstrate this, the following chapter traces the historical emergence of what philosophers today call “the problem of evil” through an analysis of the writings of Plato, Epicurus, Sextus Empiricus, Augustine, Aquinas, Calvin, Descartes, Bayle, and Hume.

In this paper I uncover and critically analyze a methodological assumption in the literature on conscientious refusals in health care. The assumption is what I call the “Priority of Conscience Principle,” which says the following: to determine the moral status of any act of conscientious refusal, it is first necessary to determine the nature and value of conscience. I argue that it is not always necessary to discuss conscience in the debate on conscientious refusals, and that discussing conscience is even (...) problematic, since it can lead authors to beg the question. (shrink)

In this essay I argue that chess is not a game.?I begin by arguing the narrower point that chess is not a game in the sense of 'game' developed by Bernard Suits.?Chess is not a Suitsian game because chess lacks a prelusory goal.?Chess lacks a prelusory goal, which is a goal that is identifiable before a game is played, because no checkmate position is knowably achievable before chess is played.?Checkmate is a postlusory discovery about chess, not a prelusory goal of (...) chess, and chess consequently has more in common with mathematics and physics than it has in common with darts, sprints, and lawn bowling. Various objections are answered. (shrink)

Using touch as a medium for exploring the ways in which it is constructed by nurses, the body is here characterized by a plethora of competing and co‐existing terms: disobedient, obedient, mirroring, stigmatized, sinful, post‐mortem, sanitized, angelic, desexualized, dangerous, dominant, dominating, deceitful, submissive, disciplined, postmodern and communicative. We have tried to be provocative by juxtaposing contradictory messages and evoking conflicting emotions, and we hope that the reader will not assume that we believe everything we write, or that everything may be (...) taken only at face value. There are as many messages and meanings in the paper as each reader thinks there are. (shrink)

A survey of the skepticism of Simon Foucher, with particular attention to his objections to Descartes' philosophy.

A survey of Bayle's skeptical arguments regarding Descartes' criterion of truth, which Bayle refers to as "evidence." Bayle's arguments for degrees of evidence, as well as for the necessity and sufficiency of possessing a high degree of evidence in order to form virtuous beliefs, are surveyed as well.

Pierre Bayle is perhaps most well-known for arguing in his Dictionary (1697) that the problem of evil cannot be solved by reason alone. This skepticism about theodicy is usually credited to a religious crisis suffered by Bayle in 1685 following the unjust imprisonment and death of his brother, the death of his father, and the revocation of the Edict of Nantes. But in this paper I argue that Bayle was skeptical about theodicy a decade earlier than these events, from at (...) least the time of his Sedan philosophy course (1675–77). I then argue that both the Various Thoughts on the Comet (1683) and Philosophical Commentary on Luke 4:23 (1686–88), which are usually read as treatments of superstition and toleration respectively, are works that also closely engage the problem of evil and demonstratethe skepticism of Bayle toward theodicy. (shrink)

In the Dedicatory Letter of the Meditations, René Descartes claims that he will offer a proof of the soul’s immortality, to be accomplished by reason alone. This proof is also promised by the title page of the first edition of the Meditations, which includes the words “in which the existence of God and the immortality of the soul are demonstrated.” But in the Synopsis, and later in his replies to objections, Descartes gives a more nuanced account of the possibility of (...) proving immortality and whether an attempt is even to be found in the Meditations. To confuse matters further, the title page of the second edition no longer mentions a demonstration of immortality but promises only to prove the distinction between body and soul. The question arises, therefore, whether the Meditations contains a purely philosophical demonstration of the immortality of the soul. (shrink)

In this paper I uncover the identities of the interlocutors of Pierre Bayle's Entretiens de Maxime et de Themiste, and I show the significance of these identities for a proper understanding of the Entretiens and of Bayle's thought more generally. Maxime and Themiste represent the philosophers of late antiquity, Maximus of Tyre and Themistius. Bayle brought these philosophers into dialogue in order to suggest that the problem of evil, though insoluble by means of speculative reason, could be dissolved and thus (...) avoided through mutual toleration. I conclude by comparing Bayle's "theodicy of toleration" with Kant's notion of authentic theodicy. (shrink)

A 1400-word article presenting Bayle's philosophical defence of the possibility of a virtuous atheist. I argue that this defence is an important moment in the history of the secularization of Western morality.

An annotated bibliography of the primary and secondary literature of Pierre Bayle.

This is a major revision (everything is new except for one section) of the Stanford Encyclopedia of Philosophy article on Pierre Bayle. There are new sections on "The Society of Atheists" and "Freedom of Conscience," as well as completely revised sections on "Skepticism", "Religious Toleration", and the "Bayle Enigma". From now on I will be the sole author of the article. Many thanks to Thomas Lennon for initially involving me in the project, and for handing it over to me.

Pierre Bayle is perhaps most well-known for arguing in his Dictionary (1697) that the problem of evil cannot be solved by reason alone. This skepticism about theodicy is usually credited to a religious crisis suffered by Bayle in 1685 following the unjust imprisonment and death of his brother, the death of his father, and the revocation of the Edict of Nantes. But in this paper I argue that Bayle was skeptical about theodicy a decade earlier than these events, from at (...) least the time of his Sedan philosophy course (1675–77). I then argue that both the Various Thoughts on the Comet (1683) and Philosophical Commentary on Luke 4:23 (1686–88), which are usually read as treatments of superstition and toleration respectively, are works that also closely engage the problem of evil and demonstratethe skepticism of Bayle toward theodicy. (shrink)