The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a (...) chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

This textbook covers all the essentials, weaving together the latest theory with the experimental techniques, instrumentation, and observational methods astronomers use to study high-energy radiation from space.

Complex crises like the coronavirus pandemic are showing us that modern societies are becoming increasingly unable to live in equilibrium with nature. These crises are the result of multiple causes, which interact at different scales and across different domains. Therefore, investigating their proximate causes is not enough to fully understand them. It is also crucial to take into account the structural factors involved. As concerns the global pandemic, I suggest four levels of analysis: (i) the surface or “proximate” level of (...) the crisis; (ii) the human–environment–animal interface, as pointed out by the One Health approach; (iii) the broader socioeconomic context; and (iv) the deeper or worldview level. Furthermore, I argue that there is the need for a mindset shift if we want to properly trace causality. Much more attention must be given to the study of multilevel connecting patterns and nonlinear mechanisms as the producers of emergent global effects. (shrink)

Cybernetic governmentality weakens the capacity of resistant subjectivities to struggle against neoliberal rationality because digitalized subjectivation processes are constantly pushed towards the logics of the market and into codifications of competitive evaluation. Despite the potential for new forms of collectivity contained in the concept of virtuality, technological evolution has disseminated a systemic form of digitality that operates not through collective procedures but through subjective-individualistic ones. Hence arises a danger that was indicated by Deleuze decades ago: that of confusing the virtual (...) with the possible. By constructing a genealogy that is built around Pierre Levy’s optimistic representation of cyberspace, Bernard Stiegler’s work on the contemporary disenchantment of the computerized world, Baudrillard’s metaphysics of code and Antoinette Rouvroy’s analysis of algorithmic governmentality, we will demonstrate that digitality is between us and that this amounts to an irreversible fact entailing a critical confrontation with its current manifestation. (shrink)

The author, starting from what is currently known about cup-marks and their distribution in the north-western Italian alpine area, formulated a hypothesis on their material and ritual functions in the Neolithic period. It is conceivable that cup-marks were originally carved in connection with the ritual use of Amanita muscaria, and that they may later have assumed other functions as well.

Aging is characterized by the decline and deterioration of functional cells and results in a wide variety of molecular damages and reduced physical and mental capacity. The knowledge on aging process is important because life expectancy is expected to rise until 2050. Aging cannot be considered a homogeneous process and includes different trajectories characterized by states of fitness, frailty, and disability. Frailty is a dynamic condition put between a normal functional state and disability, with reduced capacity to cope with stressors. (...) This geriatric syndrome affects physical, neuropsychological, and social domains and is driven by emotional and spiritual components. Sarcopenia is considered one of the determinants and the biological substrates of physical frailty. Physical and cognitive frailty are separately approached during daily clinical practice. The concept of motoric cognitive syndrome has partially changed this scenario, opening interesting windows toward future approaches. Thus, the purpose of this manuscript is to provide an excursus on current clinical practice, enforced by aneddoctical cases. The analysis of the current state of the art seems to support the urgent need of comprehensive organizational model incorporating physical and cognitive spheres in the same umbrella. (shrink)

We study a regularized version of Van Hove’s 1952 model, in which a quantum field interacts linearly with sources of finite width lying at fixed positions. We show that the central result of Van Hove’s 1952 paper on the foundations of Quantum Field Theory, the orthogonality between the spaces of state vectors which correspond to different values of the parameters of the theory, disappears when a well-defined model is considered. We comment on the implications of our results for the contemporary (...) relevance of Van Hove’s article. (shrink)

During the COVID-19 pandemic, scientific experts advised governments for measures to be promptly taken; they also helped people to understand the situation. They carried out this role in the face of a worldwide emergency, when scientific understanding was still underway. Public scientific disputes also arose, creating confusion among people. This article highlights the importance of experts’ epistemic stance under these circumstances. It suggests they should embrace the intellectual virtue of epistemic humility, regulating their epistemic behavior and communication accordingly. In so (...) doing, they would also favour the functioning of the broad network of knowledge-based experts, which is required to properly address all the aspects of the global pandemic. (shrink)

The potential for jointly using or integrating Western science and indigenous knowledge, especially in such fields as environmental management, is a hotly debated topic nowadays. However, the difficulties involved in such a task are not always fully understood and co-management experiences achieved only partially the expected outcomes. In this contribution, I show how a sound combination of the two bodies of knowledge would be possible only if there is a way to accommodate different interpretations of reality and knowledge criteria. The (...) issue should then be faced at the epistemological level too, discussing the possibility and implications of a genuine epistemic pluralism. With reference, among others, to Feyerabend’s later writings, here I illustrate some possible insights for addressing the matter that a Western perspectivist stance could provide. (shrink)

The radical changes deriving from the COVID-19 emergency have heavily upset some of the most familiar routines of daily work life. Abruptly, many workers have been forced to face the difficulties that come with switching to remote working. Basing on the theoretical framework proposed by the Job Demands-Resources model, the purpose of this paper was to explore the effect of work overload, on behavioral stress, meant as an outcome linked to the health impairment process. Furthermore, the aim of the study (...) was to explore the mediating role of job crafting, considered as a second-order construct consisting of two dimensions in the abovementioned relation. Participants were 530 workers experiencing remote working or work-from-home during the first COVID-19 lockdown in Italy. Hypotheses were explored by using three different latent variables, measured reflexively through indicators on a 5-point scale, extracted from validated questionnaires. Data analysis was performed through Structural Equation Modeling; to test the mediation, bootstrap validation was computed. Results showed that the mediation of job crafting was partial. More specifically, the direct effect between work overload and behavioral stress was positive; moreover, the indirect, negative effect through the mediation of job crafting was also significant. Therefore, results showed that job crafting can play a crucial role as a protective factor supporting the activation and adjustment of suitable resources; these resources can be useful to deal with the negative effects of work overload, particularly under the condition of heavy remote working and use of technologies, on individual outcomes. Starting from the current global scenario of the pandemic that has not yet ceased its effects, the study suggested decisive theoretical and practical implications. Accordingly, findings extended the current trends in occupational health psychology research, with special reference to the mainstream topic “work and COVID-19” in the Italian context. Finally, results can give suggestions to companies engaged in managing change, recommending that they build a collaborative workplace at the individual and collective level to implement job crafting interventions and enrich the personal and organizational resources of workers, which is useful cope with the current demands. (shrink)

A substantial guide providing an overview of both physicalism and metaphysical naturalism, reviewing both questions of formulation and justification for both doctrines. Includes a diagnostic strategy for understanding talk of naturalism as a metaphysical thesis.

Descartes's distinction between res cogitans and res extensa is a paradigmatic concept on which Western thought has been grounded. The reductionist and objectivistic approach of modern science draws its fundamental premise from it. This dualism has also instigated a view of human as separate from nature. The complexity approach in its most radical form questions many of these assumptions, asserting that the subjective and objective dimensions are involved in a relation of mutual determination and dependence. This article argues that if (...) the dualistic metaphysics is replaced by a vision emphasizing this mutual dependence, a new way of interacting with nature may also be fostered. (shrink)

First, the article illustrates the concept of ‘cultural heritage’ as traditionally meant, namely relying on a historically consolidated narrative. Next, it undertakes a broader conceptual analysis and deals with three distinct issues: (i) the fact that the conceptualizations and uses of heritage largely depend on long lasting dichotomies (e.g., tangible/intangible, natural/cultural); (ii) the way in which cultural backgrounds shape the dynamics of valuing and approaching heritage; (iii) the temporal framing of heritage, which today, in the Anthropocene, also points towards how (...) to deal with a future of uncertainty. Lastly, it introduces the notion of epistemic heritage, (i.e., the existence of multiple cultural ways of knowing), investigating its implications for both how cultural heritage is conceived and the future approached. (shrink)

Ne vers 1180 a Aurillac, mort le 30 mars 1249, Guillaume d'Auvergne est nomme eveque de Paris des 1228. Son oeuvre est contemporaine de la querelle de l'aristotelisme qui gagne la faculte de theologie, et du bouleversement de l'histoire theorique qui l'accompagne. Quelle est la cause efficiente de la pensee? D'ou vient l'intelligible necessairement present dans l'ame qui pense? C'est a cela que repondent les neuf premieres parties du chapitre sept du De anima, ecrit vers 1240. La noetique de Guillaume (...) d'Auvergne, complexe, s'y deploie et sensiblement se demarque de l' augustinisme avicennisant qui traditionnellement la caracterise. L'ame, dans son rapport au sensible, est principium agens, lectrice, en tant qu'elle pense, d'un livre dont elle-meme est l'auteur, et dont la verite se passe en partie de l'illumination divine. (shrink)

Inside What Would Plato Do?, you'll find the basics of philosophy, written in an easy, digestible way we can all understand, along with questions to help you apply these important theories to your own life. So, after you've learned about a philosophical concept, you'll then be challenged to test yourself and see how the results can impact your daily life. For instance, after learning about Kant's theory of morality and the importance of intention you're challenged with questions like: Can good (...) people do bad things? Was there a time when you intended to do something helpful that ended up being hurtful? Does that make you a good person (because you intended to do good) or a bad person (because the results were bad)? What Would Plato Do? will not only help you better understand some of the greatest thinkers ever but will also help you think of the world around you in a whole new way! (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

Ducklings were placed either singly or in pairs on a platform at two different heights. Both height and pairing influenced performance: More ducklings descended from the platform at low heights, and more single ducklings descended than paired ducklings. The social factor, pairing, made behavior more cautious and decreased the number of distress calls. A similar trend for pairing to influence performance was shown on the visual cliff. Without its peers, the duckling is a distressed animal. Previous careless behavior by ducklings (...) on the visual cliff may be ascribed to testing the ducklings outside their normal social environment. (shrink)

This is a book grounded in the real ethical challenges of modern business practice, with a world-religious perspective so necessary in an era of globalization.