Aging is characterized by the decline and deterioration of functional cells and results in a wide variety of molecular damages and reduced physical and mental capacity. The knowledge on aging process is important because life expectancy is expected to rise until 2050. Aging cannot be considered a homogeneous process and includes different trajectories characterized by states of fitness, frailty, and disability. Frailty is a dynamic condition put between a normal functional state and disability, with reduced capacity to cope with stressors. (...) This geriatric syndrome affects physical, neuropsychological, and social domains and is driven by emotional and spiritual components. Sarcopenia is considered one of the determinants and the biological substrates of physical frailty. Physical and cognitive frailty are separately approached during daily clinical practice. The concept of motoric cognitive syndrome has partially changed this scenario, opening interesting windows toward future approaches. Thus, the purpose of this manuscript is to provide an excursus on current clinical practice, enforced by aneddoctical cases. The analysis of the current state of the art seems to support the urgent need of comprehensive organizational model incorporating physical and cognitive spheres in the same umbrella. (shrink)

Why are mistaken beliefs about Covid-19 so prevalent? Political identity, education and other demographic variables explain only a part of individual differences in the susceptibility to Covid-19 misinformation. This paper focuses on another explanation: epistemic vice. Epistemic vices are character traits that interfere with acquiring, maintaining, and transmitting knowledge. If the basic assumption of vice epistemology is right, then people with epistemic vices such as indifference to the truth or rigidity in their belief structures will tend to be more susceptible (...) to believing Covid-19 misinformation. We carried out an observational study (US sample, n = 998) in which we measured the level of epistemic vice of participants using a novel Epistemic Vice Scale. We also asked participants questions eliciting the extent to which they subscribe to myths and misinformation about Covid-19. We find overwhelming evidence to the effect that epistemic vice is associated with susceptibility to Covid-19 misinformation. In fact, the association turns out to be stronger than with political identity, educational attainment, scores on the Cognitive Reflection Test, personality, dogmatism, and need for closure. We conclude that this offers evidence in favor of the empirical presuppositions of vice epistemology. (shrink)

Most of the arguments usually appealed to in order to support the view that some abstraction principles are analytic depend on ascribing to them some sort of existential parsimony or ontological neutrality, whereas the opposite arguments, aiming to deny this view, contend this ascription. As a result, other virtues that these principles might have are often overlooked. Among them, there is an epistemic virtue which I take these principles to have, when regarded in the appropriate settings, and which I suggest (...) to call ‘epistemic economy’. My purpose is to isolate and clarify this notion by appealing to some examples concerning the definition of natural and real numbers. (shrink)

ABSTRACTHow accurate are insights compared to analytical solutions? In four experiments, we investigated how participants' solving strategies influenced their solution accuracies across different types of problems, including one that was linguistic, one that was visual and two that were mixed visual-linguistic. In each experiment, participants' self-judged insight solutions were, on average, more accurate than their analytic ones. We hypothesised that insight solutions have superior accuracy because they emerge into consciousness in an all-or-nothing fashion when the unconscious solving process is complete, (...) whereas analytic solutions can be guesses based on conscious, prematurely terminated, processing. This hypothesis is supported by the finding that participants' analytic solutions included relatively more incorrect responses than timeouts compared to their insight responses. (shrink)

In this paper I explore the heuristic limits ofhuman genetics, in particular the claim that itis possible to manipulate human germcells in a pre-ordinate way (Gordon, 1999). I arguethat this claim is unrealistic based ongenetic reductionism and a wrong concept ofgenetic diseases.

When solving a problem with insight, people suddenly become aware of the solution (Mayer, 1995). Insight is often accompanied by a feeling of pleasure and certainty, known as an “Aha! moment” (Gick...

According to the extended cognition thesis, an agent’s cognitive system can sometimes include extracerebral components amongst its physical constituents. Here, we show that such a view of cognition has an unjustifiably anthropocentric focus, for it tends to depict cognitive extensions as a human-only affair. In contrast, we will argue that if human cognition extends, then the cognition of many non-human animals extends too, for many non-human animals rely on the same cognition-extending strategies humans rely on. To substantiate this claim, we (...) will proceed as follows. First (Sect. 1), we will introduce the extended cognition thesis, exposing its anthropocentric bias. Then, we will show that humans and many non-human animals rely on the same cognition-extending strategies. To do so, we will discuss a variety of case studies, including “intrabodily” cognitive extensions such as the spinal cord (Sect. 2), the widespread reliance on epistemic actions to solve cognitive tasks (Sect. 3) and cases of animal cognitive offloading (Sect. 4). We’ll then allay some worries our claim might raise (Sect. 5) to then conclude the paper (Sect. 6). (shrink)

This volume collects 17 case studies that characterize the various kinds of translations of the European culture of the last two and a half millennia from ancient Greece to Rome, from the medieval world to the Renaissance up to the ...

In this article, I address a controversial aspect of Rawls’s treatment of the question of justice between generations: how the parties in the original position could be motivated to select Rawls’s preferred principle of intergenerational savings, which he dubs the just savings principle. I focus on the explanation found in his later work, where he proposes that the correct savings principle is the principle that any generation would have wanted preceding generations to have followed. By expanding upon this explanation, I (...) respond to the objection that this explanation disregards the perspective of the first generation. I demonstrate that this objection ceases to be a concern when a proper account of the parties’ reasoning is developed. What is notable about the explanation I defend is that it relies on the parties adopting maximax – not maximin – as a rule for rational decision making. Having established this intermediary conclusion, I depart with Rawls and consider what savings principle the parties would choose if given more options. Ultimately, I argue that the parties would select a principle that Rawls would have undoubtedly rejected if presented to him at face value. This is because the principle of savings I argue would be selected requires continual economic growth over generations to increase upwards indefinitely – a conclusion Rawls is explicitly trying to avoid in his theory of justice. (shrink)

In this paper I deal with ethical factors surrounding germline gene therapy. Such implications include intergenerational responsibility, human dignity, moral status of embryos and so on. I will explore the relevance of the above mentioned issues to discuss the ethical implication of human germline gene therapy (HGLT). We will see that most of arguments claimed by bioethicists do not provide valid reason to oppose HGLT. I will propose an alternative view, based on personal identity issues, to discuss the ethics of (...) human inheritable gene modification. (shrink)

In this paper I deal with ethical implications arising from animal biotechnology. I analyse some general questions surrounding the production of transgenic animals through a specific case study: the oncomouse. In particular, I explore ethical factors involved in the production of oncomice. This is because biologists genetically modify animals’ germ cells and refuse to modify human germ cells. I will underline how the international community has thus far justified this ‘ethical difference’.

Parkinson's disease patients receiving dopaminergic treatment may experience bursts of creativity. Although this phenomenon is sometimes recognized among patients and their clinicians, the association between dopamine replacement therapy in PD patients and creativity remains underexplored. It is unclear, for instance, whether DRT affects creativity through convergent or divergent thinking, idea generation, or a general lack of inhibition. It is also unclear whether DRT only augments pre-existing creative attributes or generates creativity de novo. Here, we tested a group of PD patients (...) when “on” and “off” dopaminergic treatment on a series of tests of creative problem-solving, and related their performance to a group of matched healthy controls as well as to their pre-PD creative skills and measures of inhibition/impulsivity. Results did not provide strong evidence that DRT improved creative thinking in PD patients. Rather, PD patients “on” medication showed less flexibility in divergent thinking, generated fewer ideas via insight, and showed worse performance in convergent thinking overall than healthy controls. Pre-PD creative skills predicted enhanced flexibility and fluency in divergent thinking when PD patients were “on” medication. However, results on convergent thinking were mixed. Finally, PD patients who exhibited deficits in a measure of inhibitory control showed weaker convergent thinking while “on” medication, supporting previous evidence on the importance of inhibitory control in creative problem-solving. Altogether, results do not support the hypothesis that DRT promotes creative thinking in PD. We speculate that bursts of artistic production in PD are perhaps conflated with creativity due to lay conceptions of creativity. (shrink)

The aim I am pursuing here is to describe some general aspects of mathematical proofs. In my view, a mathematical proof is a warrant to assert a non-tautological statement which claims that certain objects (possibly a certain object) enjoy a certain property. Because it is proved, such a statement is a mathematical theorem. In my view, in order to understand the nature of a mathematical proof it is necessary to understand the nature of mathematical objects. If we understand them as (...) external entities whose 'existence' is independent of us and if we think that their enjoying certain properties is a fact, then we should argue that a theorem is a statement that claims that this fact occurs. If we also maintain that a mathematical proof is internal to a mathematical theory, then it becomes very difficult indeed to explain how a proof can be a warrant for such a statement. This is the essential content of a dilemma set forth by P. Benacerraf (cf. Benacerraf 1973). Such a dilemma, however, is dissolved if we understand mathematical objects as internal constructions of mathematical theories and think that they enjoy certain properties just because a mathematical theorem claims that they enjoy them. (shrink)

A view that emancipates free will by means of quantum indeterminism is frequently rejected based on arguments pointing out its incompatibility with what we know about quantum physics. However, if one carefully examines what classical physical causal determinism and quantum indeterminism are according to physics, it becomes clear what they really imply–and, especially, what they do not imply–for agent-causation theories. Here, we will make necessary conceptual clarifications on some aspects of physical determinism and indeterminism, review some of the major objections (...) against libertarian conjectures, and show that there is no conceptual incompatibility preventing us from taking a ‘quantum-libertarian’ approach to the problem of free will. In particular, we will illustrate the possible role of self-causation (causa sui) as a potential solution to otherwise apparently incompatible or even paradoxical statements concerning free will and quantum indeterminism. (shrink)

The Routledge International Handbook of Neuroaesthetics is an authoritative reference work that provides the reader with a wide-ranging introduction to this exciting new scientific discipline. The book brings together leading international academics to offer a well-balanced overview of this burgeoning field while addressing two questions central to the field; how the brain computes aesthetic appreciation for sensory objects, and how is art created and experienced.

Traz depoimentos dirigidos de filósofos brasileiros sobre temas clássicos e contemporâneos da filosofia, processos de formação intelectual e a vida cultural brasileira. Ao final, apresenta breve biografia do depoente e lista das suas principais publicações.

In this work we present some reflections about the interaction of preschool children (between 3 and 5 years old) with sound-producing objects. We implemented the phenomenological approach of Alfred Schutz, who under the influence of Edmund Husserl, elaborated his own notions concerning the Lebenswelt or life-world. We present some situations of interaction with musical instruments by children that have been documented in different research on musical education in early childhood, the same ones we use to exemplify possible analyses from the (...) perspective of the phenomenology of the social world. We conclude with some remarks that conceive of Schutz’s theory as a relevant perspective for the analysis of children’s experiences with sound-producing objects. (shrink)

Nel suo pionieristico lavoro Conditions in Königsberg and the Making of Kant's Philosophy, Giorgio Tonelli lamentava l'assenza di un'indagine approfondita sul contesto intellettuale di Königsberg e sull'eventuale influenza che esso esercitò su alcuni aspetti del pensiero di Kant. Questo libro vuole colmare questa lacuna prestando particolare attenzione alla tradizione aristotelica, alla Schulphilosophie, e alla corrente dell'eclettismo, che dominarono l'ambiente regiomontano sino all'avvento della filosofia critica kantiana. Il lavoro mostra come dai fallimenti dei progetti logici e metafisici precritici, legati alle influenze (...) ricevute dall'ambiente di Königsberg, Kant abbia tratto le idee e gli spunti per la stesura della Kritik der reinen Vernunft. (shrink)

The chapter advances a reformulation of the classical problem of the nature of mathematical objects (if any), here called “Plato’s problem,” in line with the program of a philosophy of mathematical practice. It then provides a sketch of a platonist solution, following the same perspective. This solution disregards as nonsensical the question of the existence of abstract, and specifically mathematical, objects, by rather focusing on the modalities of our access to them: objects (in general, both concrete and abstract) are regarded (...) as individual contents that we have (or can have) a de re epistemic access to. The question of the existence of mathematical objects is then replaced by that of the modalities of our de re epistemic access to individual mathematical contents. (shrink)

Language does not have to be held as a problem for radical enactivists. The scope objection usually presented to criticize enactivist explanations is a problem only if we have a referentialist and representationalist view of the nature of language. Here we present a normative hypothesis for the great question concerning the hard problem of content, namely, on how linguistic practices develop from minds without content. We carry representational content when we master inferential relations and we master inferential relations when we (...) master normative relations, especially when we are introduced into frameworks of authorizations and prohibitions. Inspired by the anti-intellectualism of the later Wittgenstein and Brandom’s inferentialism, we present the hypothesis that language emerges from inferentially articulated action from normative elements and not from manipulation in internal mental states of contents fixed by reference to external things. (shrink)

En este trabajo nos proponemos analizar los efectos que tienen en la genética y la microbiología la aplicación de las leyes de propiedad intelectual, en su forma de derechos de patentes. A través del estudio de la historia de estas áreas de la biología, argumentamos porque nos parece errónea, desde el punto de vista jurídico y filosófico, la patentabilidad de los genes y genomas que provienen total o parcialmente de la naturaleza. Demostraremos cómo esta práctica legal acarrea una gran cantidad (...) de valores no-epistémicos y concepciones ético-políticas que afectan de lleno a las investigaciones biológicas que forman parte del negocio biotecnológico y generan un desmesurado choque de cosmovisiones con culturas ajenas al sistema liberal-capitalista. (shrink)

A central feature of experimental development economics is the use of randomized controlled trials (RCTs) to evaluate the effectiveness of prospective socioeconomic interventions. The use of RCTs in development economics raises a host of ethical issues which are just beginning to be explored. In this article, I address one ethical issue in particular: the routine use of the status quo as a control when designing and conducting a development RCT. Drawing on the literature on the principle of standard care in (...) medical research ethics, as well as considerations of distributive justice in non-ideal circumstances, I argue that the practice of using the status quo as a control is ethically justifiable. However, I add an important qualification based on the natural duty of rescue to address the concern that my account is overly permissive. (shrink)