Results for 'microglia'

8 found
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  1.  35
    Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach.Takahiro A. Kato & Shigenobu Kanba - 2013 - Frontiers in Psychology 4.
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  2.  21
    Papel de la microglía en la formación de los cuerpos amiláceos del tejido nervioso.P. Del Río-Hortega - 2005 - Arbor 181 (714):249-265.
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  3. Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis.Lara M. Nikel, Kevin Talbot & Björn F. Vahsen - forthcoming - Bioessays:2400054.
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron‐centric mechanisms has recently shifted towards understanding the contribution of non‐neuronal cells, such as microglia, in ALS pathophysiology. Advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of iPSC‐derived microglia monocultures and co‐cultures to investigate their role in ALS pathogenesis. Here, we briefly review the insights gained from these studies into the role of (...) in ALS. While iPSC‐derived microglia monocultures have revealed intrinsic cellular dysfunction due to ALS‐associated mutations, microglia‐motor neuron co‐culture studies have demonstrated neurotoxic effects of mutant microglia on motor neurons. Based on these findings, we briefly discuss currently unresolved questions and how they could be addressed in future studies. iPSC models hold promise for uncovering disease‐relevant pathways in ALS and identifying potential therapeutic targets. (shrink)
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  4.  15
    Innovaciones útiles en la técnica de coloración de la microglía y otros elementos del sistema macrofágico.P. Del Río-Hortega - 2005 - Arbor 181 (714):267-279.
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  5.  14
    Synaptic Pruning in Schizophrenia: Does Minocycline Modulate Psychosocial Brain Development?Michael C. Jones, Jin Ming Koh & Kang Hao Cheong - 2020 - Bioessays 42 (9):2000046.
    Recent studies suggest that the tetracycline antibiotic minocycline, or its cousins, hold therapeutic potential for affective and psychotic disorders. This is proposed on the basis of a direct effect on microglia‐mediated frontocortical synaptic pruning (FSP) during adolescence, perhaps in genetically susceptible individuals harboring risk alleles in the complement component cascade that is involved in this normal process of CNS circuit refinement. In reviewing this field, it is argued that minocycline is actually probing and modulating a deeply evolved and intricate (...)
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  6.  20
    Alzheimer Disease: Perspectives from Epidemiology and Genetics.Jonathan L. Haines - 2018 - Journal of Law, Medicine and Ethics 46 (3):694-698.
    Alzheimer disease is a huge and growing societal problem with upwards of 35% of the population over the age of 80 developing the disease. AD results in a loss of memory, the ability to make reasoned and sound decisions, and ultimately the inability to take care of oneself. AD has an impact not only on the sufferer, but their caretakers and loved ones, who must take on a costly and time-consuming burden of care. AD is found in virtually all racial (...)
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  7.  25
    Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction.Qiuting Wang, Ying Hu, Jiale Wan, Bo Dong & Jinhao Sun - 2019 - Bioessays 41 (8):1900008.
    l‐Lactate is emerging as a crucial regulatory nexus for energy metabolism in the brain and signaling transduction in synaptic plasticity, memory processes, and drug addiction instead of being merely a waste by‐product of anaerobic glycolysis. In this review, the role of lactate in various memory processes, synapse plasticity and drug addiction on the basis of recent studies is summarized and discussed. To this end, three main parts are presented: first, lactate as an energy substrate in energy metabolism of the brain (...)
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  8.  8
    Interactions between neural cells and blood vessels in central nervous system development.Keiko Morimoto, Hidenori Tabata, Rikuo Takahashi & Kazunori Nakajima - 2024 - Bioessays 46 (3):2300091.
    The sophisticated function of the central nervous system (CNS) is largely supported by proper interactions between neural cells and blood vessels. Accumulating evidence has demonstrated that neurons and glial cells support the formation of blood vessels, which in turn, act as migratory scaffolds for these cell types. Neural progenitors are also involved in the regulation of blood vessel formation. This mutual interaction between neural cells and blood vessels is elegantly controlled by several chemokines, growth factors, extracellular matrix, and adhesion molecules (...)
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