The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module found in multiple copies in a number of functionally different proteins that facilitates specific interactions with a partner protein(s). Three-dimensional structural data have shown that a TPR motif contains two antiparallel α-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that might accommodate the complementary region of a target protein. Most TPR-containing proteins are associated with multiprotein complexes, and there is extensive evidence (...) indicating that TPR motifs are important to the functioning of chaperone, cell-cycle, transcription, and protein transport complexes. The TPR motif may represent an ancient protein-protein interaction module that has been recruited by different proteins and adapted for specific functions. BioEssays 1999;21:932–939. © 1999 John Wiley & Sons, Inc. (shrink)

The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module found in multiple copies in a number of functionally different proteins that facilitates specific interactions with a partner protein(s). Three-dimensional structural data have shown that a TPR motif contains two antiparallel α-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that might accommodate the complementary region of a target protein. Most TPR-containing proteins are associated with multiprotein complexes, and there is extensive evidence (...) indicating that TPR motifs are important to the functioning of chaperone, cell-cycle, transcription, and protein transport complexes. The TPR motif may represent an ancient protein-protein interaction module that has been recruited by different proteins and adapted for specific functions. BioEssays 1999;21:932–939. © 1999 John Wiley & Sons, Inc. (shrink)

One of the vividly discussed topics in the contemporary philosophy of science (especially physics) is the opposition between realism and Anti-Realism. The supporters of the first way of thinking trust in the objective existence of realities studied by science. They consider theories as approximate descriptions of these realities (Psillos 1999, xvii), whereas their opponents do not. However, both sides base their argumentation on simplified notions of scientific theories. In this paper, we present a more general approach, which can be coined (...) as “Theoretical Physics Realism” (TPR). It is based on the detailed reconstruction of the polysystemic nature of physical theories. The consequences of this reconstruction for understanding the genuine relationship between theories and experiments in studying the realities are indicated. The paper distinguishes between abstract (general) and domain-dependent theories and appeals to specific physical theories together with their application domains rather than to general speculations. (shrink)

ResumenEste artículo expone una defensa restringida de la teoría de las preferencias reveladas (TPR) considerando la argumentación crítica de Villacís (La preferencia revelada frente al enfoque utilitarista) en contra de esta. Se muestra que la TPR es un avance en términos metodológicos para la investigación económica y también un avance en tanto fundamentación formal microeconómica. En particular, mostraré que, en primer lugar, las críticas planteadas a la TPR pueden matizarse, en tanto 1. asumen que el objetivo de TPR es ofrecer (...) una epistemología conductista y 2. asumen que sostener una visión conductista de las preferencias es sostener una visión conductista de la fundamentación microeconómica. En segundo lugar, mostraré que la crítica formal que plantea Villacís no es efectiva pues existe una ambigüedad respecto sobre qué recaen las preferencias de los jugadores en el contexto de juegos estratégicos.Palabras clave: filosofía de la economía; preferencias; preferencias reveladas; microeconomía; Paul Samuelson. (shrink)

Kevin Schilbrack’s recent book sets out a series of well-considered, well-wrought arguments promoting a lively future for philosophy of religion. In the following comments on selected chapters, I seek to raise questions that require further elaboration of Schilbrack’s constructive vision and/or distinction from alternative visions with which he disagrees.Chapter 1: ‘The Full Task of Philosophy of Religion’Schilbrack begins this chapter characterizing ‘traditional philosophy of religion’ in terms of the task that the discipline sets for itself: to evaluate the rationality of (...) theism. In an illuminating decision tree, Schilbrack analyzes and organizes the variety within TPR, including counter-traditions in Continental and feminist philosophy. More importantly, this procedure helps substantiate the author’s overall critique of TPR as inadequate to the ‘full task’ of philosophy of religion because it is narrow, intellectualistic, and insular. Schilbrack identifies three subordinate ta .. (shrink)

Academic publishing is undergoing a highly transformative process, and many established rules and value systems that are in place, such as traditional peer review (TPR) and preprints, are facing unprecedented challenges, including as a result of post-publication peer review. The integrity and validity of the academic literature continue to rely naively on blind trust, while TPR and preprints continue to fail to effectively screen out errors, fraud, and misconduct. Imperfect TPR invariably results in imperfect papers that have passed through varying (...) levels of rigor of screening and validation. If errors or misconduct were not detected during TPR’s editorial screening, but are detected at the post-publication stage, an opportunity is created to correct the academic record. Currently, the most common forms of correcting the academic literature are errata, corrigenda, expressions of concern, and retractions or withdrawals. Some additional measures to correct the literature have emerged, including manuscript versioning, amendments, partial retractions and retract and replace. Preprints can also be corrected if their version is updated. This paper discusses the risks, benefits and limitations of these forms of correcting the academic literature. (shrink)

The nuclear export of mRNA through the nuclear pore complex (NPC) is a process required for the healthy functioning of human cells, making it a critical area of research. However, the geometries of mRNA and the NPC are well below the diffraction limit of light microscopy, thereby presenting significant challenges in evaluating the discrete interactions and dynamics involved in mRNA nuclear export through the native NPC. Recent advances in biotechnology and single‐molecule super‐resolution light microscopy have enabled researchers to gain granular (...) insight into the specific contributions made by discrete nucleoporins in the nuclear basket of the NPC to the export of mRNA. Specifically, by expanding upon the docking step facilitated by the protein TPR in the nuclear basket as well as identifying NUP153 as being the primary nuclear basket protein initiating export through the central channel of the NPC. (shrink)

La “Teología del pluralismo religioso” (TPR) no es una teología “sectorial”, o “de genitivo”, que teologizara temas nuevos dentro de la “universa theologia”. O sea, la TPR no agranda cuantitativamente el campo de la teología. Hace su aportación, pero cualitativamente: trata los mismos temas, pero bajo una luz distinta, con otra pertinencia, otro “objeto formal”. Es una teología que replantea todo desde otra perspectiva, con otro ordenamiento, a partir de otro “paradigma”. Por eso, los desafíos de esta teología son fuertes. (...) Grandes perspectivas generales nunca antes cuestionadas, se derrumban ahora, y surgen otras nuevas, desafiantes. El autor se centra en una selección de los principales cambios que producen esos desafíos actuales. Los aborda y trata de justificarlos, mostrando en cada caso sus implicaciones para la reflexión teológica y para la vida cristiana. El paso de una valoración negativa del pluralismo a otra positiva, la nueva comprensión de la Revelación, la superación y hasta el abandono de la categoría de “elección”, las principales propuestas de cambio en campos tan sensibles como los de la cristología, la eclesiología y la moral, así como la transformación de la misión son las cuestiones de esto breve estudio. Palabras clave: Pluralismo; Cambio de paradigma; Pluralismo de principio; Elección; Inclusivismo; Misión. ABSTRACT The Theology of religious pluralism (TRP) is not “a sectorial” theology or “a genitive theology”, which would theologize new subjects, that is to say one more field inside the “universa theologia”. In other words, it does offer a quantitative novelty instead of a qualitative one. TRP deals with the same subjects, but from another point of view, another “formal object”. Everything is retrieved from another order, point of view, and “paradigm”. In this way, challenges seem to be huge. Great general perspectives that have never been are effected and new challenges reappear. The author works on the selection of main changes that produce current challenges. Such Challenges are presented and justified, showing in each case its implications for theological reflexion and well as for Christian life. The core of this brief study refers to the shift of a negative to a positive evaluation of the religious pluralism, a new understanding of the Revelation, the overcoming and the abandon of the category of the “election”, the main challenges in the sensible field of christology and moral, as well as the transformation of the mission. Key words: Pluralism; Shift of paradigm; Pluralism of principle; Election; Inclusivismo; Mission. (shrink)

Sister chromatid separation in anaphase is an important event in the cell's transmission of genetic information to a descendent. It has been investigated from different aspects: cell cycle regulation, spindle and chromosome dynamics within the three‐dimensional cell architecture, transmission fidelity control and cellular signaling. Integrated studies directed toward unified understanding are possible using multidisciplinary methods with model organisms. Ubiquitin‐dependent proteolysis, protein dephosphorylation, an unknown function by the TPR repeat proteins, chromosome transport by microtubule‐based motors and DNA topological change by DNA (...) topoisomerase II are all necessary for progression from metaphase to anaphase. Chromosome condensation, mitotic kinetochore function and spindle formation require a large number of proteins, which are prerequisites for successful sister chromatid separation. Factors that help to retain sister chromatid connection after replication and prevent premature separation remain to be determined. Although sister chromatid separation occurs in anaphase, gene functions in other cell cycle stages also ensure the progression of correct chromatid separation. (shrink)

The relationship between kinetochores and nuclear pore complexes (NPCs) is intimate but poorly understood. Several NPC components and associated proteins are relocated to mitotic kinetochores to assist in different activities that ensure faithful chromosome segregation. Such is the case of the Mad1‐c‐Mad2 complex, the catalytic core of the spindle assembly checkpoint (SAC), a surveillance pathway that delays anaphase until all kinetochores are attached to spindle microtubules. Mad1‐c‐Mad2 is recruited to discrete domains of unattached kinetochores from where it promotes the rate‐limiting (...) step in the assembly of anaphase‐inhibitory complexes. SAC proficiency further requires Mad1‐c‐Mad2 to be anchored at NPCs during interphase. However, the mechanistic relevance of this arrangement for SAC function remains ill‐defined. Recent studies uncover the molecular underpinnings that coordinate the release of Mad1‐c‐Mad2 from NPCs with its prompt recruitment to kinetochores. Here, current knowledge on Mad1‐c‐Mad2 function and spatiotemporal regulation is reviewed and the critical questions that remain unanswered are highlighted. (shrink)