Johann Christoph Sturm’s natural philosophy, with which Leibniz engages in “De ipsa natura”, as well as Petrus van Musschenbroek’s epistemology, constitute important steps in the process of the speciation of physics. In this case, speciation is understood as the process through which the explanation of natural phenomena via empirical regularities comes to define the whole domain of the newly established niche of physics, to the exclusion both of teleology and efficient causality.