The central theme of Japanese subnational governmental study has been centerlocal relations and the administrative institutions that define the relations. Indeed, one needs to ask what determines subnational policy outcomes, to what degree the national influence affects the determinants, and under what conditions these determinants function autonomously. The present paper directly examines the subnational policymaking process itself, not the center–local relations, and tries to understand its mechanism. The paper proposes a research framework using a statistical method that has been developed (...) in the area of diffusion study. In the framework, national influence is integrated into an analysis of subnational policymaking as one of the factors that affect policy determinants. Using the framework, the paper analyzes the process of four regional policies, which will lead to a better understanding of subnational policymaking. (shrink)

Familial amyloidotic polyneuropathy (FAP) is an inherited systemic amyloidosis, characterized by the extracellular deposition of fibrillar amyloid protein, i.e. a variant type of prealbumin, and by prominent peripheral nerve involvement. We recently established the basis of FAP, using a cloned human prealbumin cDNA, restriction endonuclease(s) and Southern blot procedures. This approach clearly revealed a direct link between mutation in the prealbumin gene and FAP; individuals with FAP are heterozygous for the prealbumin gene, carrying one normal and one mutant gene. Molecular (...) analysis of the prealbumin gene yielded pertinent data on the genetic basis for FAP. (shrink)